The effect of antipsychotic treatment on Theory of Mind

Mizrahi, Romina; Korostil, Michèle; Starkstein, Sergio E.; Zipursky, Robert B.; Kapur, Shitij

doi:10.1017/s0033291706009342

Cited by 67 publications

(50 citation statements)

References 35 publications

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“…A growing body of literature has shown, consistently, that schizophrenia patients compared to healthy people present social cognitive and neurocognitive impairments which are relatively stable and persistent, suggesting that this is a trait-dependent rather than state-dependant aspect of the disorder [9][10][11]. Social cognitive deficits have been widely described as modifying patients' behavior when interacting with other people (theory of mind (ToM) deficits) [11][12][13][14] and in recognizing emotions [15][16][17] and other social information cues [9,18]. Therefore, social cognitive deficits are believed to be important predictors of functional outcome in schizophrenia [19,20].…”

Section: Introductionmentioning

confidence: 99%

Does employment promote the process of recovery from schizophrenia? A review of the existing evidence

Charzyñska

Kucharska

Mortimer

2015

Int J Occup Med Environ Health

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The aim of this review is to appraise current evidence on the association between employment and specific, non-vocational components that are indicators of recovery from schizophrenia, such as symptom remission, neurocognitive functioning, social cognitive functioning, and quality of life. Out of 754 studies identified in a comprehensive bibliographical data search, 43 were selected for abstract screening and 18 were included in the final review. The studies were categorized in terms of the type of employment investigated (supported employment, Individual Placement and Support, competitive employment). Studies on the Individual Placement and Support programs provide the strongest evidence for their effectiveness in terms of non-vocational outcomes. Quality of life, psychopathology and well being were the most frequently investigated outcomes and only 2 studies utilized a global concept of recovery as a measure. Employment was also associated with positive changes in domains that are not directly related to working, e.g., leisure activities. The current review reports promising, but not conclusive, results in the improvement of quality of life, social functioning and other indicators of recovery, but there is still a need for high quality, long term follow-up, randomized studies to further investigate this relationship.

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Section: Introductionmentioning

confidence: 99%

Does employment promote the process of recovery from schizophrenia? A review of the existing evidence

Charzyñska

Kucharska

Mortimer

2015

Int J Occup Med Environ Health

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“…The clozapine and the olanzapine groups performed similarly as the controls. Mizrahi et al (2007) evaluated the ToM of 17 drug-free psychotic patients (schizophrenia, schizophreniform and schizoaffective disorder) at baseline and every 2 weeks for 6 weeks, after initiating antipsychotic treatment (different second generation drugs) and observed an improvement in ToM performance. However, the authors could not exclude the influence of a practice effect due to the repetition of the ToM task and call attention to the lack of a placebo-control group.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

Schizophrenia and Social Cognition: From Conceptual Bases to Therapeutic Approaches

Monteiro¹,

Martins²,

Crivelaro³

et al. 2012

Schizophrenia in the 21st Century

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“…Até o momento apenas dois estudos escritos em inglês avaliaram o impacto do uso de antipsicóticos sobre tarefas que avaliem habilidades ToM em pacientes portadores de transtorno do espectro da esquizofrenia (TEE) 31,32 . A Tabela 1 resume as principais características metodológicas de cada um.…”

Section: Habilidades Tomunclassified

“…A Tabela 1 resume as principais características metodológicas de cada um. O estudo de Mizrahi et al 31 avaliou o efeito do tratamento antipsicótico sobre a ToM nos pacientes com TEE tanto transversal quanto longitudinalmente. Na fase transversal do estudo, foi avaliada a performance em uma tarefa envolvendo habilidades ToM de pacientes portadores de TEE que estavam em uso de antipsicóticos.…”

Section: Habilidades Tomunclassified

Cognição social na esquizofrenia: um enfoque em habilidades teoria da mente

Tonelli

Alvarez

2009

Rev. psiquiatr. Rio Gd. Sul

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Endereço para correspondência RESUMO "Teoria da mente" é o nome que tem sido dado à habilidade que os seres humanos têm de inferir os estados mentais ou as intenções de outros seres humanos. Tais habilidades fazem parte de um grupo maior de capacidades cognitivas, especificamente relacionadas ao comportamento social, denominado cognição social. A esquizofrenia é um transtorno mental que costuma cursar grave comprometimento do funcionamento social. Existem vários estudos correlacionando transtornos das habilidades teoria da mente e sintomas da esquizofrenia com resultados ainda controversos. Muitos autores acreditam que os sintomas da esquizofrenia podem ser diretamente compreendidos à luz de alterações das habilidades teoria da mente, enquanto outros argumentam que as alterações dessas habilidades observadas em esquizofrênicos são reflexo de seu comprometimento cognitivo geral. Ainda existem poucos estudos relacionando o impacto do uso de antipsicóticos sobre a cognição social e habilidades teoria da mente e eles apresentam problemas metodológicos.Descritores: Cognição, esquizofrenia, transtornos psicóticos. ABSTRACT"Theory of mind" is the term used to designate human abilities to infer the state of mind or intentions of others. Such abilities are part of a major group of cognitive capabilities specifically related to social behavior, known as social cognition. Schizophrenia is a mental disorder that usually consists of severe social functioning. There are many studies available on the relations between disorders of theory of mind abilities and schizophrenia symptoms. Many authors believe that schizophrenia symptoms might be directly understood by focusing on some changes in Theory of Mind abilities. Other authors claim that such changes observed in schizophrenic patients are the result of their general cognitive impairment. There are still few studies related to the impact of the use of antipsychotics on social cognition and Theory of Mind abilities, which present methodological problems.

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The effect of antipsychotic treatment on Theory of Mind

Abstract: Although TOM and psychotic symptoms are related to each other, antipsychotic treatment impacts each independently, suggesting a dissimilar cognitive or neurobiological substrate for the two.

Cited by 67 publications

References 35 publications

Does employment promote the process of recovery from schizophrenia? A review of the existing evidence

Does employment promote the process of recovery from schizophrenia? A review of the existing evidence

Schizophrenia and Social Cognition: From Conceptual Bases to Therapeutic Approaches

Cognição social na esquizofrenia: um enfoque em habilidades teoria da mente

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