The Effect of Ascorbic Acid Supplementation on the Nicotine Metabolism of Smokers

Dawson, Earl B.; Evans, Douglas R.; Harris, William A.; McGanity, William J.

doi:10.1006/pmed.1999.0583

Cited by 83 publications

(101 citation statements)

References 17 publications

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“…However the results of antioxidant therapy alone or in combination are controversial. For example, some studies have shown that vitamin C, vitamin E, zinc, folic acid, and selenium alone or in combination could improve sperm parameters, especially sperm motility and sperm DNA integrity (36)(37)(38)(39). In contrast, several reports refute the effects of these antioxidants on sperm parameters (40,41).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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Background: Oxidative stress is the result of an imbalance between the production and scavenging of reactive oxygen species (ROS). Recently, oxidative stress has been introduced as a major cause of male infertility. Objectives: The aim of the present study was to determine the correlation between total antioxidant capacity (TAC) and malondialdehyde (MDA) as markers of oxidative stress in relation to idiopathic male infertility and sperm parameters. Patients and Methods: This case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. Seminal plasma TAC and MDA were measured by ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods, respectively. Results: Seminal TAC levels were significantly lower and seminal MDA levels were significantly higher in men with idiopathic infertility than in fertile men (P < 0.0001 and P = 0.004, respectively). A positive correlation was shown between sperm motility, sperm morphology, and TAC levels in men with idiopathic infertility (P = 0.002 and P = 0.002, respectively). In addition, there was a correlation between sperm motility and TAC levels in fertile men (P = 0.005). There was no correlation between sperm count and TAC levels in either men with idiopathic infertility or in fertile men. Negative correlations were observed between MDA levels and sperm motility, morphology, and sperm count only in men with idiopathic infertility (P = 0.003, P = 0.001, and P = 0.006, respectively). Conclusions: Our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology.

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Section: Discussionmentioning

confidence: 99%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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“…In vivo trials in humans have shown that administration of antioxidants improves sperm quality in heavy smokers [12] and in patients with male factor infertility [27,31] as well as increases the fertilisation potential of healthy men with a high concentration of seminal ROS [24] and of fertile normozoospermic men with low fertilisation rates (based on previous IVF cycles) [19].…”

Section: Discussionmentioning

confidence: 99%

“…Dawson et al [12] and Lanzafame et al [25] observed an improvement in the seminal parameters of heavy smokers. Increased fertilisation potential was described among normozoospermic men in couples who had low fertilisation rates and were undergoing IVF cycles [19].…”

Section: Total (95% Ci)mentioning

confidence: 94%

Coenzyme Q10 and male infertility: a meta-analysis

Lafuente

González-Comadran

Solà

et al. 2013

J Assist Reprod Genet

139

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Objective To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility. Materials and methods Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group. Results None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I 2 =17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I 2 =58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I 2 =0 %)Conclusion There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.

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“…In men, several therapeutic protocols have been tested to elucidate their effects on sperm quality and on sperm fecundity [15,27,30]. Numerous authors have demonstrated beneficial effects of antioxidant drugs on male fertility [25,36,40,42].…”

Section: Introductionmentioning

confidence: 99%

Sperm Oxidative Stress and the Effect of an Oral Vitamin E and Selenium Supplement on Semen Quality in Infertile Men

Keskes¹,

Feki-Chakroun²,

Rebaï³

et al. 2003

Archives of Andrology

302

128

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The Effect of Ascorbic Acid Supplementation on the Nicotine Metabolism of Smokers

Cited by 83 publications

References 17 publications

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Coenzyme Q10 and male infertility: a meta-analysis

Sperm Oxidative Stress and the Effect of an Oral Vitamin E and Selenium Supplement on Semen Quality in Infertile Men

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