The effect of aspartame ingestion in pregnant female albino rats on placental and fetal weights, umbilical cord length, and histology of fetal pancreas

Aboshanady, Azza M.M; El-Sawaf, Manal El-Sayed; Abdel-Aziz, Abdel-Rahman Abu-El-Enain; Attia, Mona M.

doi:10.4103/tmj.tmj_5_18

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…Furthermore, increase in both levels of creatinine and urea in rats administered high and low dose of sodium cyclamate and aspartame are in accordance with the result from Azeez et al, [25] who reported increased in serum creatinine levels in rats administered 2.5mg/kg, 5mg/kg and 10 mg/kg of saccharin for 6 and 120 days. Similarly, Aboshanady et al, [26] also reported increase in urea and creatinine levels in rats treated with aspartame (250 mg/kg bw) for 6weeks. This could be because of disruption in kidney functions leading to decreased glomerular filtration rate and subsequently, withholding creatinine and urea in the blood [27].…”

Section: Discussionmentioning

confidence: 75%

Comparative effect of Aspartame and Sodium Cyclamate on Lipid Profile, Histology and Biochemical Parameters of Kidney and Liver Function in Albino Rats

Usman¹,

Abubakar²,

Gadanya³

2022

J Biochem Microbiol Biotechnol

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Aspartame and Sodium cyclamate are two synthetic sweeteners used extensively in developing world. The study aims to assess the comparative effect of these sweeteners on lipid profiles, biochemical parameters of liver and kidney function and histological changes. Twenty male albino rats were separated into 5 groups of 4 rats each. Group 1 were fed normal diet and water, whereas those in Groups 2, 3, 4, and 5 received 50 mg/kg sodium cyclamate, 500 mg/kg sodium cyclamate, 50 mg/kg aspartame, and 500 mg/kg aspartame, respectively. After 7 weeks, the animals were sacrificed; blood and tissue samples were taken to analyze lipid profiles, biochemical parameters, and histology. The results showed that rats administered with low and high doses of sweeteners had significant (P<0.05) increase in serum triglyceride (TG) (0.92±0.05 mg/dL to 1.95±0.04 mg/dL), total cholesterol (TC) (4.88±0.31mg/dL to 8.18±0.45 mg/dL), low density lipoprotein (LDL) (3.59±0.26 mg/dL to 8.02±0.25 mg/dL), high density lipoprotein (HDL) (0.76±0.05 mg/dL to 1.11±0.1 mg/dL), Creatinine (0.94±0.08 mg/dL to 1.77±0.04 mg/dL) and urea (42.35±2.43 mg/dL to 57.3±1.79 mg/dL) levels in the treated group compared to the control group. Significant increase (P<0.05) in AST (47.33±3.92 U/L to 158.01±5.07 U/L), ALP (76.80±8.58 U/L to 124.01±1.51 U/L) and ALT (12.87±2.64 U/L to 37.74±5.76 U/L) levels was also observed in experimental group compared to the control group. Moreover, high doses of sweeteners caused more histological abnormalities in rats. Sodium cyclamate and aspartame maybe harmful to kidney and liver especially when consumed at high dose for a long period.

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Section: Discussionmentioning

confidence: 75%

Comparative effect of Aspartame and Sodium Cyclamate on Lipid Profile, Histology and Biochemical Parameters of Kidney and Liver Function in Albino Rats

Usman¹,

Abubakar²,

Gadanya³

2022

J Biochem Microbiol Biotechnol

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“…Both ASPtreated groups have lower weights for viable fetuses than the control group. Studies with different high or low doses showed a highly significant decrease in fetal weight, placental weight reduction, and altered placental structure in both ASPtreated groups compared with the control group [12,17,[29][30][31] . This decrease could indicate that the fetuses weren't receiving enough substrates, especially glucose, which could be attributed to a decrease in substrates in the blood of maternal rats that were given ASP.…”

Section: Discussionmentioning

confidence: 89%

“…The toxicity of aspartame on the rats' fetal tissues cies [12] . A huge controversy concerning artificial sweeteners still exists.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Aspartame on Some Fetal Tissues of Female Albino Rats

Iskandar,

El-Balshy,

Elhadidy

et al. 2024

Egyptian Journal of Zoology

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Aspartame (ASP), a low-calorie artificial sweetener, is a methyl ester of a dipeptide. It can cause serious health problems as its metabolites can be toxic to many organs. The current study aimed to evaluate the toxicity of ASP on the rats' fetal tissues. Thirty-five pregnant female albino rats (Rattus norvegicus domestica) were randomly allotted into 5 groups (n=7): the control group received orally distilled water; groups "1 and 2" received orally/daily 250 and 500 mg ASP/kg body weight (dissolved in distilled water), respectively, on the 1 st -7 th days of pregnancy; and groups "3 and 4" received orally/daily 250 and 500 mg ASP/kg body weight (dissolved in distilled water), respectively, on the 8 th -20 th days of pregnancy. The fetal body weight and length decreased significantly in groups "2, 3, and 4" only. However, the mortality rate increased especially in groups "2 and 4", which received the high doses of ASP. Major skeletal abnormalities seen in the fetuses included inadequate ossification of the skull, vertebrae, and pectoral and pelvic girdles with their fore and hind limbs in all groups. The ASP changed the usual architecture of the hepatic parenchyma tissue in all treated groups. The kidneys of ASP-treated groups demonstrated histopathological alterations. The high doses in the first and the second periods of pregnancy had the most chronic effect than the low doses.

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“…Using aspartame during pregnancy might reduce foetal weight 18,19 . Studies showed that daily consumption of artificially sweetened beverages during pregnancy may increase the risk of an infant being overweight at 1 year of age 20 . The results of this study showed that 3week offspring had increased growth compared to the controls.…”

Section: Discussionmentioning

confidence: 99%

Commercial Artificial Sweeteners Affect Mice Limb Development: A Morphology and Morphometric Study

Al-Qudsi¹,

Al-Ahmadi²,

Ganash³

2021

Int J Life Sci Pharm Res

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Artificial sweeteners are food additives that provide a sweet taste like that of sugar while containing significantly fewer or no calories. The aim of this study was to evaluate the effect of commercial artificial sweeteners on mouse limb development. Adult female mice were divided into three groups: control group, vehicle control group and treated group. The treated group received orally 40 mg/kg body weight artificial sweetener solution, while the vehicle control group received distilled water. The groups were left to mate with normal untreated male mice. On confirmed conception, pregnant females were separated from males. The dose was orally given to the test group before mating, throughout the gestational period till three weeks after giving birth. Foetuses E14.5 and E19.5, were extracted, and newborn and 3 weeks old offspring were examined, and their growth parameters were measured. Congenital malformations were seen in the treated group, such as cerebellar hypertrophy, an increase in the number of forelimbs, atrophy in the lower limb. In some embryos, the amniotic membrane was adherent to the embryo with a very low amount of amniotic fluid. Bone malformation was clearly seen in 1-week offspring, as basic forelimb and hind limb bones were missing. The results of this study showed that there was significant growth retardation in E14.5 and newborns. While in E19.5-and week 3 offspring, there was a significant growth increase (increase in weight, body length tail length and tail length to body length ratio). It was concluded that commercial artificial sweeteners altered growth rate during embryonic development and produced bone and limb congenital malformations in mice.

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The effect of aspartame ingestion in pregnant female albino rats on placental and fetal weights, umbilical cord length, and histology of fetal pancreas

Cited by 5 publications

References 15 publications

Comparative effect of Aspartame and Sodium Cyclamate on Lipid Profile, Histology and Biochemical Parameters of Kidney and Liver Function in Albino Rats

Comparative effect of Aspartame and Sodium Cyclamate on Lipid Profile, Histology and Biochemical Parameters of Kidney and Liver Function in Albino Rats

The Effects of Aspartame on Some Fetal Tissues of Female Albino Rats

Commercial Artificial Sweeteners Affect Mice Limb Development: A Morphology and Morphometric Study

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