The Effect of Azithromycin on Biofilms Formation by Pathogens of Implant-Associated Infection in Large Joints

Babushkina, I. V.; Ulyanov, Vladimir Yu.; Mamonova, I. A.; Shpinyak, S. P.

doi:10.1007/s10517-020-04982-8

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…The methodical errors in evaluation of antibiotics sensitivity by common bacteriological methods are related to the formation of microbial biofilms in IAI that protects microorganisms from the effect of antibacterial drugs and immune system factors due to the selective permeability of the matrix, the presence of enzyme systems that inactivate antibiotics, and the exchange of resistance determinants within the biofilm [2,4,5].…”

Section: Resultsmentioning

confidence: 99%

“…P. aeruginosa can form biofilms within 24-48 h, which makes etiotropic treatment inefficient and often leads to the development of chronic IAI [5,7]. It was established that some antibiotics in concentrations used in clinical practice can stimulate biofilm growth [1,2]. Some features of IAI pathoge nesis require new approaches to its diagnostics, changes in antibiotic treatment tactics, search for alternative methods of destruction, and inactivation of microbic biofilms [1,2,8].…”

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confidence: 99%

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Resistance to Antibiotics in Plankton and Biofilm Cultures of Pseudomonas aeruginosa Clinical Strains

et al. 2021

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Biofilms formed by Pseudomonas aeruginosa strains isolated from biomaterial of patients with implant-associated infection are characterized by much higher resistance to antibiotics of various classes than plankton cultures of these strains. The concentrations of antibiotics causing the death of 90% of P. aeruginosa biofilm (MIC 90 ) was 2-6 µg/ml for fluoroquinolones, 267-356 µg/ml for cephalosporins, and 92-215 µg/ml for amikacin, which significantly (p<0.05) differed from MIC 90 for plankton cultures that did not exceed 0.8 µg/ml for fluoroquinolones, 19 µg/ml for cephalosporins, and 3 µg/ml for amikacin. The degree of the microbial biofilm maturity also affected antibiotic resistance.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Resistance to Antibiotics in Plankton and Biofilm Cultures of Pseudomonas aeruginosa Clinical Strains

et al. 2021

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“…As a result, antibiotics, if given, are usually present in subinhibitory concentrations, which in turn can actively promote biofilm formation. A recent study has demonstrated the effect of subinhibitory concentrations of azithromycin on promoting Pseudomonas aeruginosa biofilm formation using species isolated from large joint infections [34]. In another recent study, subinhibitory antibiotic concentrations were demonstrated to increase the number and total protein content of extracellular vesicles (a bacterial communication system that contain a range of cargo molecules including nucleic acids, proteins, lipids, and enzymes and have been observed in several Gram-positive species) in S. epidermidis, which cause a modulation in cellular growth rate and cellular division time as well as altering cellular adhesion [35].…”

Section: Bacteria In Orthopaedic Implant-related Infectionsmentioning

confidence: 99%

Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants

Rodríguez-Merchán

Davidson

Liddle

2021

IJMS

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Biofilm-related implant infections (BRII) are a disastrous complication of both elective and trauma orthopaedic surgery and occur when an implant becomes colonised by bacteria. The definitive treatment to eradicate the infections once a biofilm has established is surgical excision of the implant and thorough local debridement, but this carries a significant socioeconomic cost, the outcomes for the patient are often poor, and there is a significant risk of recurrence. Due to the large volumes of surgical procedures performed annually involving medical device implantation, both in orthopaedic surgery and healthcare in general, and with the incidence of implant-related infection being as high as 5%, interventions to prevent and treat BRII are a major focus of research. As such, innovation is progressing at a very fast pace; the aim of this study is to review the latest interventions for the prevention and treatment of BRII, with a particular focus on implant-related approaches.

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The Effect of Azithromycin on Biofilms Formation by Pathogens of Implant-Associated Infection in Large Joints

Cited by 2 publications

References 11 publications

Resistance to Antibiotics in Plankton and Biofilm Cultures of Pseudomonas aeruginosa Clinical Strains

Resistance to Antibiotics in Plankton and Biofilm Cultures of Pseudomonas aeruginosa Clinical Strains

Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants

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