The effect of bengkuang (Pachyrhizus erosus) ethanol extract on the number of ovarian follicles, amount of epithelium and endometrium stroma cells in DMPA-treated Rattus norvegicus

Hadiningsih, Eka Frenty; Ardela, Mayasari Putri; S, Suryanti; Nurseta, Tatit; Noorhamdani,; Winarsih, Sri; Anita, Kenty Wantri; Angelina, Aina

doi:10.1063/5.0002908

Cited by 1 publication

(2 citation statements)

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“…The significant increase in the number of antral follicles and endometrial stromal follicles were observed in the ETE treated groups ( Table 3 ). The treated rats also showed an increased amount of endometrial epithelium in the study [ 100 ]. In these studies, it was suggested that the natural estrogenic role of P. erosus can be further developed to fulfill the need for estrogen therapies for premenopausal and postmenopausal women.…”

Section: Bioactivities (In Vitro and In Vivo)mentioning

confidence: 98%

“…Phytoestrogens are potential candidates for the prevention of cardiovascular diseases and postmenopausal osteoporosis [ 97 , 98 ]. Tuber juice from P. erosus was found to have estrogenic potential in different studies on animals [ 14 , 41 , 99 , 100 ]. The estrogenic activity may be due to the compounds present in the tuber juice, such as genistein and daidzein, that structurally resemble estrogen.…”

Section: Bioactivities (In Vitro and In Vivo)mentioning

confidence: 99%

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The Bioactivity and Phytochemicals of Pachyrhizus erosus (L.) Urb.: A Multifunctional Underutilized Crop Plant

2021

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Pachyrhizus erosus (L.) Urb. is an underutilized crop plant belonging to the Fabaceae family. In recent years, the plant received huge attention and was introduced in different countries owing to properties such as a high nutritional content, its nitrogen-fixing abilities, and different biological activities such as its antioxidant, immune modulation, anticancer, anti-diabetes, anti-osteoporosis, antiviral, and antiaging affects, among others. In this review, an attempt has been made to comprehensively compile the biological activities of the plant to provide a panoramic view of the current efforts and further directions, which may lead to the development of pharmacological applications. This information will be helpful in creating interest towards P. erosus and it may be useful in developing the plant for medical applications and/or as a functional food. More than 50 phytochemicals have been reported from the plant, which belong to different chemical classes such as triterpenoids, organic acid, flavonoids, and fatty acids. Numerous biological activities were reported from the plant through in vivo, in vitro, ex vivo, and human studies. However, well-defined clinical studies are still lacking for the establishment of any biological properties that could be further developed. Suggestions for the further development of P. erosus, according to current knowledge about the different biological properties, has also been provided.

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Section: Bioactivities (In Vitro and In Vivo)mentioning

confidence: 98%