The effect of berberine administration to rats on the functional state of liver after common bile duct ligation

Abstract

On day 8 after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol, bilirubin and ALT, alkaline phosphatase, and gamma glutamyltransferase was observed. In the hepatic microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injections of berberine (10 mg/kg) for 6 days caused a partial normalization of hepatocyte plasma permeability and activity of microsomal flavin containing monooxyge nases. It is suggested that berberine is a substrate and inducer of flavin containing monooxygenases. The membrane stabilizing effect of berberine is probably realized at the level of inhibition of the prooxidant status of liver cells.

Evaluation of silymarin and berberine efficiencies in the self-emulsifying drug delivery systemin paracetamol-induced experimental toxic liver injury

“…Показаны его защитные эффекты при поражениях печени различного генеза. Результаты проведенных нами ранее исследований подтверждают гепатопротекторный потенциал берберина при моделировании холестаза [4] и частичной гепатэктомии [5].…”