The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial

Singer, Gregory M.; Geohas, Jeff

doi:10.1089/dia.2006.8.636

Cited by 58 publications

(54 citation statements)

References 24 publications

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“…22 Cefalu et al (2010) 23 Chen et al (2014) 24 Crawford et al (1999) 25 Evans (1989) 26 Ghosh et al (2002) 27 Gunton et al (2005) 28 Grant and McMullen. (1982) 29 Grant et al (1997) 30 Hermann et al (1998) 31 Hermann et al (1994) 32 Jain et al (2012) 40 Lee and Reasner (1994) 41 Li et al (1992) 42 Li (1994) 43 45 Martinez et al (1985) 46 Mossop (1983) 47 Offenbacher and Pi-Sunyer (1980) 48 Offenbacher et al (1985) 49 Pasman et al (1997) 50 Pei et al (2006) 51 Rabinovitz et al (1983) 52 Rabinovitz et al (2004) 53 Racek et al (2006) 54 Riales et al (1981) 55 Singer and Geohas (2006) 56 Sharma et al (2011) 57 Sherman et al (1968) 58 Thomas and Gropper (1996) 59 Urberg and Zemel (1987) 60 …”

Section: Studies Measuring Hba1cmentioning

confidence: 99%

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

2016

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Some adults with type 2 diabetes mellitus (T2DM) believe that chromium-containing supplements will help control their disease, but the evidence is mixed. This narrative review examines the efficacy of chromium supplements for improving glycemic control as measured by decreases in fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c). Using systematic search criteria, 20 randomized controlled trials of chromium supplementation in T2DM patients were identified. Clinically meaningful treatment goals were defined as an FPG of 7.2 mmol/dL, a decline in HbA1c to 7%, or a decrease of 0.5% in HbA1c. In only a few randomized controlled trials did FPG (5 of 20), HbA1c (3 of 14), or both (1 of 14) reach the treatment goals with chromium supplementation. HbA1c declined by 0.5% in 5 of 14 studies. On the basis of the low strength of existing evidence, chromium supplements have limited effectiveness, and there is little rationale to recommend their use for glycemic control in patients with existing T2DM. Future meta-analyses should include only high-quality studies with similar forms of chromium and comparable inclusion/exclusion criteria to provide scientifically sound recommendations for clinicians.

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Section: Studies Measuring Hba1cmentioning

confidence: 99%

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

2016

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“…A recently reported 30-day pilot study [41] concluded that the combination of chromium picolinate and biotin improved short-term glycaemic control (oral glucose tolerance, fasting glucose, and fructosamine), and had a favourable effect on lipid parameters in subjects with type 2 DM. The study was a placebo-controlled 30-day intervention in obese to overweight subjects with poorly controlled type 2 DM, who were already receiving oral anti-diabetic medications (OADs).…”

Section: Introductionmentioning

confidence: 99%

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

Albarracín

Fuqua

Evans³

et al. 2007

Diabetes Metabolism Res

104

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“…Chromium has been found to reduce glucose intolerance and improve lipid levels in elderly diabetic patients 6 ; lower glucose levels, insulin resistance, and oxidative stress in obese patients with type 2 diabetes 7,8 ; and, in combination with biotin in poorly controlled diabetics, improves glucose management and lipid measurements. 9 However, a small trial (n ϭ 46) of obese, insulin-treated type 2 diabetics, chromium had no significant impact on glucose management after a 6-month trial. 10 The research on chromium supplementation for women with gestational diabetes is mixed.…”

Section: Discussionmentioning

confidence: 95%

Serum Chromium and Gestational Diabetes

Woods¹,

Ghodsi²,

Engel³

et al. 2008

The Journal of the American Board of Family Medicine

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Objective: To prospectively assess if chromium levels are different in gestational diabetics than in nondiabetic pregnant women. Therapeutic options could exist if levels are different.Methods: We conducted a 2-year prospective, gestational cohort study. The cohort included newly diagnosed pregnant patients. Two blood samples were taken, the first at consent, the second at the time of diabetes screening.Results: Five hundred eighty patients entered the cohort. One hundred fifty-five were lost to follow up and 425 patients completed the study (396 nondiabetics and 29 diabetics). The patients with gestational diabetes were significantly older, with a family history of gestational diabetes, and were significantly more likely to have been a gestational diabetic in a previous pregnancy (P < 05). There was no significant difference between the 2 groups for chromium levels both at enrollment (0.15 ؎ 0.06 ng/mL vs 0.14 ؎ 0.03 ng/mL; P ‫؍‬ .28) and during the second trimester (0.14 ؎ 0.06 ng/mL vs 0.14 ؎ 0.04 ng/mL; P ‫؍‬ .82).Conclusion: Serum chromium levels do not exhibit any significant variation between gestational diabetic women and nondiabetic women when assessed prospectively.

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The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial

Cited by 58 publications

References 24 publications

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

Serum Chromium and Gestational Diabetes

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