The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle

Mak, Peter; Irwin, Michael G.

doi:10.1016/j.jclinane.2003.05.004

Cited by 11 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a similar study, they demonstrated that the combination of the priming and low dose ephedrine provided better intubating conditions compared with the other groups at 60 seconds after 0.15 mg/kg cisatracurium [14]. In addition, many previous reports already revealed that the priming of cisatracurium shortened the onset time of cisatracurium [15,16]. Deepika et al [16] showed that the priming with 0.01 mg/kg, followed by the 0.14 mg/kg cisatracurium provided good to excellent intubating conditions in all patients and can offer an onset time comparable to or faster than the recommended dose of 0.2 mg/kg.…”

Section: Discussionmentioning

confidence: 95%

The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium

Ahn

Kim

et al. 2012

Korean J Anesthesiol

View full text Add to dashboard Cite

BackgroundBoth ketamine and priming may accelerate the onset time of neuromuscular blocking agents. We investigate the effect of low dose ketamine and cisatracurium priming on the intubating condition and onset time of cisatracurium.MethodsAfter Institutional Review Board approval, 120 consecutive patients undergoing general anesthesia were randomly assigned to one of 4 groups. All patients were injected one of normal saline (group C), cisatracurium 0.01 mg/kg (group P), ketamine 0.5 mg/kg (group K) and combination of cisatracurium 0.01 mg/kg, and ketamine 0.5 mg/kg (group PK) diluted into a 5 ml solution, followed 3 minutes later by cisatracurium 0.15 mg/kg in group C and K, and 0.14 mg/kg cisatracurium in priming group. Onset time was recorded the electromyographical responses using single twitch and intubating conditions were evaluated at 60 seconds after cisatracurium administration.ResultsThe mean onset time was most significantly accelerated in Group PK and was also significantly more accelerated in Group P and K compared with Group C (P < 0.008). It was 112.7 ± 13.2, 91.4 ± 17.9, 84.9 ± 12.7 and 76.4 ± 8.3 seconds in Group C, P, K, and PK, respectively. Intubating conditions were significantly improved in Group P, K and PK than Group C (P < 0.008). Especially, Group PK showed most significant improvement of intubating conditions.ConclusionsThe combination of the low dose ketamine and cisatracurium priming accelerated the onset time and was improved the intubating conditions.

show abstract

Section: Discussionmentioning

confidence: 95%

The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium

Ahn

Kim

et al. 2012

Korean J Anesthesiol

View full text Add to dashboard Cite

show abstract

“…Die Gabe der Primingdosis fällt so mit dem Beginn der Prä-oxygenierung und der Opiatapplikation zusammen. Längere Primingintervalle von 5-6 min könnten zwar theoretisch die Anschlagszeit noch weiter verkürzen, sind aber infolge eines Zeitverlustes (Primingintervall länger als die Anschlagszeit nach Bolusapplikation) klinisch sicher irrelevant und führen beim Patienten häufiger zur Wahrnehmung einer beginnenden NMB [18,20,34]. So fanden Stevens et al in einer Voruntersuchung zu ihrer Studie einen Abfall der TOF-Ratio am M. adductor pollicis ab 3 min nach Applikation einer Primingdosis von 0,01 bzw.…”

Section: Diskussionunclassified

“…5 min (0,01 mg/kgKG) signifikant war [34]. Auch Mak u. Irwin fanden bei einem 6-minütigen Primingintervall mit 0,015 mg/kgKG Cisatracurium eine signifikante Reduktion der elektromyographisch gemessenen ersten Reizantwort auf 84,5±9,1% des Ausgangswertes [20]. Je nach Autor variieren die Angaben zur sicheren und effektiven Primingdosis zwischen 10 und 30% der ED 95 [1,6,11,18,34].…”

Section: Diskussionunclassified

Primingtechnik mit Cisatracurium

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the declining popularity of the priming technique is obvious because of the use of rocuronium [1,2] which can be used as an acceptable NMBD for RSI [3]. However, sometimes, in cases of hepatic or renal failure, it seems reasonable to choose cisatracurium as a NMBD [1,4]. Therefore, it has been researched numerous priming techniques to overcome long onset time of cisatracurium [1,4-6].…”

Section: Introductionmentioning

confidence: 99%

“…However, sometimes, in cases of hepatic or renal failure, it seems reasonable to choose cisatracurium as a NMBD [1,4]. Therefore, it has been researched numerous priming techniques to overcome long onset time of cisatracurium [1,4-6]. Such priming techniques can speed up the onset of cisatracurium during intubation, but there have been no reports on the effect of priming technique on duration and recovery profile of cisatracurium.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the clinical duration and recovery characteristics of cisatracurium after priming using rocuronium or cisatracurium: preliminary study

Jung

Kim

et al. 2014

Korean J Anesthesiol

View full text Add to dashboard Cite

BackgroundThe priming technique can speed up the onset of cisatracurium during intubation. However, there have been no reports on the effect of the priming technique on duration or recovery profile of cisatracurium. Therefore, we attempted to determine whether or not a priming technique with rocuronium or cisatracurium can affect clinical duration or recovery profiles of cisatracurium.MethodsA total of 36 patients, ASA I and II, who were scheduled to undergo elective surgery, were enrolled. The patients were randomized into three groups and administered different drugs for the priming technique. Patients in group 1 received normal saline (control group). Patients in group 2 received rocuronium (0.06 mg/kg), and those in group 3 received cisatracurium (0.01 mg/kg) as a priming agent. Three minutes after injection of drugs, intubation doses of cisatracurium were administered (Group 1, 0.15 mg/kg; Groups 2 and 3, 0.14 mg/kg). Anesthesia was induced and maintained with propofol and remifentanil. Onset time, clinical duration, recovery index, recovery time, and total recovery time were measured by train of four monitoring.ResultsOnset time in the group 2 was significantly shorter than that of group 1 or 3 (P < 0.05). However, no significant differences in clinical duration, recovery index, recovery time, and total recovery time were observed among the three groups.ConclusionsPriming with rocuronium for 3 minutes resulted in significantly accelerated onset of cisatracurium. However, it did not affect the clinical duration and recovery profiles of cisatracurium.

show abstract

The effect of cisatracurium and rocuronium on cisatracurium precurarization and the priming principle

Cited by 11 publications

References 25 publications

The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium

The effect of low dose ketamine and priming of cisatracurium on the intubating condition and onset time of cisatracurium

Primingtechnik mit Cisatracurium

A comparison of the clinical duration and recovery characteristics of cisatracurium after priming using rocuronium or cisatracurium: preliminary study

Contact Info

Product

Resources

About