The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis

Abstract

Background: The effect of coffee and caffeine on blood pressure (BP) and cardiovascular disease (CVD) in hypertensive persons is uncertain. Objective: The objective was to summarize the evidence on the acute and longer-term effects of caffeine and coffee intake on BP and on the association between habitual coffee consumption and risk of CVD in hypertensive individuals. Design: A systematic review and meta-analysis of publications identified in a PubMed and EMBASE search up to 30 April 2011 was undertaken. Data were extracted from controlled trials on the effect of caffeine or coffee intake on BP change and from cohort studies on the association between habitual coffee consumption and CVD. Results: In 5 trials, the administration of 200-300 mg caffeine produced a mean increase of 8.1 mm Hg (95% CI: 5.7, 10.6 mm Hg) in systolic BP and of 5.7 mm Hg (95% CI: 4.1, 7.4 mm Hg) in diastolic BP. The increase in BP was observed in the first hour after caffeine intake and lasted !3 h. In 3 studies of the longer-term effect (2 wk) of coffee, no increase in BP was observed after coffee was compared with a caffeine-free diet or was compared with decaffeinated coffee. Last, 7 cohort studies found no evidence of an association between habitual coffee consumption and a higher risk of CVD. Conclusions: In hypertensive individuals, caffeine intake produces an acute increase in BP for !3 h. However, current evidence does not support an association between longer-term coffee consumption and increased BP or between habitual coffee consumption and an increased risk of CVD in hypertensive subjects.Am J Clin Nutr 2011;94:1113-26.

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

“…In the present study, acute intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone did not alter blood pressure in these subjects (Table 3). Several investigators, including us, have reported that caffeine intake is associated with acute increase in blood pressure [40,41]. Conversely, chronic caffeine consumption was shown to have no significant effect on blood pressure [41].…”

“…Several investigators, including us, have reported that caffeine intake is associated with acute increase in blood pressure [40,41]. Conversely, chronic caffeine consumption was shown to have no significant effect on blood pressure [41]. In the case of acute coffee intake, interaction of chlorogenic acids and caffeine may regulate changes in blood pressure.…”

Coffee Consumption and Cardiovascular Diseases – Has the Time Come to Change Dietary Advice? A Mini Review

“…As far as patients with hypertension are concerned, a recently published systematic review and meta-analysis of controlled trials failed to deliver evidence justifying avoidance of habitual coffee consumption in well-controlled hypertensive patients [Mesas et al, 2011].…”

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“…Estas bebidas también contienen cantidades importante de azúcares, algunas de ellas tienen fructosa, y aminoácidos como taurina. La incorporación de cantidades elevadas de cafeína produce un aumento agudo de la presión arterial y riesgo de arritmias 97 . Por otro lado, las ingestas moderadas de café no parecen tener efectos crónicos perjudiciales sobre la presión arterial ni el riesgo cardiovascular.…”