2011
DOI: 10.1016/j.biomaterials.2011.03.025
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The effect of coimmobilizing heparin and fibronectin on titanium on hemocompatibility and endothelialization

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Cited by 210 publications
(133 citation statements)
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“…The density of surface accessible heparin, as determined by the TBO assay, is ∼12 µg/cm 2 ( Figure 8), which is significantly higher than that of the blank control. This value is comparable to those of heparin modified surfaces that were shown to effectively improve blood compatibility [30,43]. To assess whether the heparin retained bioactivity after covalent conjugation, platelet adhesion assays were performed across different samples.…”
Section: Platelet Adhesion Behaviour On the Modified Az31 Mg Alloysmentioning
confidence: 86%
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“…The density of surface accessible heparin, as determined by the TBO assay, is ∼12 µg/cm 2 ( Figure 8), which is significantly higher than that of the blank control. This value is comparable to those of heparin modified surfaces that were shown to effectively improve blood compatibility [30,43]. To assess whether the heparin retained bioactivity after covalent conjugation, platelet adhesion assays were performed across different samples.…”
Section: Platelet Adhesion Behaviour On the Modified Az31 Mg Alloysmentioning
confidence: 86%
“…Functional silanes, such as γ-APS, have often been used for modification of stainless steel [33] and Ti [30,34] to provide surface functionality for post chemical anchorage of biomolecules (e.g. collagen, heparin and fibronectin), with a view to improving the biocompatibility of these metallic implants.…”
Section: Corrosion Resistance Properties Of the Modified Az31 Mg Alloysmentioning
confidence: 99%
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“…В естествен-ных условиях благодаря электростатическому взаимодействию белки образуют супрамолеку-лярные структуры, позволяющие поддерживать или сохранять конформацию «ключ-замок». Предложена методика, объединяющая элек-тростатическое взаимодействие и ковалентную иммобилизацию, для того чтобы сформировать пленки гепарина и фибронектина (Нер/Fn) на аминосиланизированной поверхности Ti [38]. В этом методе гепарин и фибронектин сначала сме-шивались для образования супрамолекулярного комплекса, дальнейшую ковалентную иммоби-лизацию комплекса проводили на основе силана.…”
Section: имитация структур внеклеточного матрикса на поверхности метаunclassified
“…At last, all samples were observed under a Leica DMRX fluorescence microscope. HUASMC proliferation was investigated by Cell Counting Kit-8 (CCK-8, Boshide, Wuhan, China) after incubation for 1 and 3 days, respectively [45].…”
Section: Huasmc Morphology and Proliferationmentioning
confidence: 99%