The Effect of Dexamethasone in Traumatic Changes of the Periodontium of Marmosets (Callithrix Jacchus)

Sallum, Antônio Wilson; Nascimento, Aparecido do; Bozzo, L; Toledo, Sérgio de

doi:10.1902/jop.1976.47.2.63

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Numerous animal experiments have found that TO can cause loss of periodontal attachment, extend PDL width, and aggravate periodontitis, while others have uncovered that simple TO does not lead to periodontal tissue damage. 21,[23][24][25][26] However, different modeling methods and modeling time may affect the results. In our study, the alveolar bone resorption was observed at one, two, and three weeks after TO modeling, and the short-term alveolar bone resorption was very mild.…”

Section: Discussionmentioning

confidence: 99%

Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models

Chen

Hua

2020

J of Periodontal Research

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Background and objective Though impacts of traumatic occlusion (TO) on periodontal tissues and roles of cystathionine γ‐lyase (Cth) gene in the regulation of bone homeostasis have been studied by many, no consensus has been reached so far on whether TO deteriorates the periodontium and precise roles of Cth in occlusal trauma. Therefore, this study aims to investigate the impacts of TO on periodontal tissues and the involvement of Cth gene. Methods Eighty C57BL/6 wild‐type (WT) mice and Cth knockout (Cth−/−) mice, 8 weeks old, were used in this study. The TO model was established using composite resin bonding on the left maxillary molar for one, two, and three weeks, respectively. Morphological and histological changes in the periodontium were assessed by micro‐computed tomography (micro‐CT), hematoxylin and eosin (H&E) staining, and tartrate‐resistant acid phosphatase (TRAP) staining. Osteoclast‐related genes were analyzed by real‐time polymerase chain reaction (qPCR). Results It was found that decreased alveolar bone height, expanded bone resorption area, and increased width of periodontal ligament (PDL) occurred in TO models, accompanied by an increased number of osteoclasts in a time‐dependent manner by micro‐CT and histological staining. Osteoclast‐related genes including Ctsk, Mmp9, Rank, Trap, and Rankl/Opg were also up‐regulated after one week of modeling. The up‐regulated expressions of Cth gene and its protein CTH were observed in TO mouse models. After 1, 2, or 3 weeks of modeling, WT mice showed more severe alveolar bone resorption, wider PDL, higher osteoclast count, and higher levels of osteoclast‐related genes Ctsk, Rank, and Rankl/Opg than Cth−/− mice. Conclusion TO causes a reduction in alveolar bone height and PDL morphological disorder with their severity increases in a time‐dependent manner. Cth aggravates periodontal damage caused by TO.

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Section: Discussionmentioning

confidence: 99%

Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models

Chen

Hua

2020

J of Periodontal Research

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“…According to the behavior of tissues in response to the action of traumatogenic forces, trauma from occlusion would develop in three sequential stages:…”

Section: The Role Of Occlusion In the Injury Of Periodontal Supportinmentioning

confidence: 99%

“…Several publications have described the periodontal tissue changes produced by traumatogenic occlusal forces . The magnitude, direction, duration, and frequency of force application are all factors that may turn a force into traumatogenic.…”

Section: The Role Of Occlusion In the Injury Of Periodontal Supportinmentioning

confidence: 99%

“…This adaptive behavior probably results from activation of osteoclasts following the binding of inflammatory mediators to specific receptors on the osteoblast surface, thereby mediating bone resorption . A funnel‐shaped bone defect bordering the cervical area of the periodontal ligament then develops, but without formation of a periodontal pocket …”

Section: The Role Of Occlusion In the Injury Of Periodontal Supportinmentioning

confidence: 99%

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Role of occlusion in periodontal disease

Passanezi

Sant’Ana

2019

Periodontology 2000

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This article deals with establishing a new link between trauma from occlusion and periodontal pockets based on the know‐how and background gradually developed. To provide a better understanding to the reader, a historical perspective is firstly presented. The main features on the controversy of the role played by trauma from occlusion on the physiologic behavior of the periodontal structures are shown, together with how deviations from the normal characteristics of this relationship itself affect the integrity of the periodontal tissues when or associated with dental biofilm in the presence or not of periodontal pockets have arisen. The literature provides evidence showing that the very first publication to establish a strong correlation between trauma from occlusion and periodontal pockets in humans was of Latin‐American origin. However, subsequently, trauma from occlusion was mostly evaluated by an American group, followed by a Scandinavian group, yet with some contributions from the Latin‐American group. Basically trauma from occlusion has been correlated with periodontal pockets in view of the fact that these would render the periodontal supporting tissues more amenable to the spread of inflammation of biofilm‐related periodontal pockets. This would facilitate the fast deepening of periodontal pockets, influencing the generation of infrabony periodontal pockets or suprabony periodontal pockets that are deeper than in areas without trauma from occlusion. The factors related to these different behaviors are discussed. Several clinical cases are presented showing evidence that corroborates the possibility of an actual interrelationship between trauma from occlusion and periodontitis. Theoretical evaluations based on recent advances of the mechanisms involving molecular modulation in physiological and altered occlusal functions, as well as on research data, and evaluations from data of clinical cases, support the assumption that trauma from occlusion and periodontitis may embrace the unique pathologic condition of the associated lesion trauma from occlusion plus periodontitis or act independently even if both co‐exist simultaneously in a particular case. The link between both conditions that was emphasized as definitively necessary in order for an associated lesion to develop is that both lesions, namely trauma from occlusion and periodontitis, occur in their destructive stage at exactly the same time. This involvement would explain why so many different data are presented in the literature and hopefully will shed some light for development of new methodologies of research. Clinical cases were selected to present a treatment philosophy on the subject.

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“…Ethical issues related to non‐treatment of OT limit the prospective study of this condition in humans. Most published studies are based on human necropsy or on one of several animal models . Recently, finite element analysis has been used to better evaluate the biomechanical behaviour of the periodontal ligament .…”

mentioning

confidence: 99%

Cigarette smoke inhalation increases the alveolar bone loss caused by primary occlusal trauma in a rat model

Campos

Corrêa

Júnior

et al. 2013

J of Periodontal Research

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The Effect of Dexamethasone in Traumatic Changes of the Periodontium of Marmosets (Callithrix Jacchus)

Cited by 6 publications

References 8 publications

Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models

Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models

Role of occlusion in periodontal disease

Cigarette smoke inhalation increases the alveolar bone loss caused by primary occlusal trauma in a rat model

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