2017
DOI: 10.1186/s13028-017-0293-0
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The effect of dexmedetomidine on cerebral perfusion and oxygenation in healthy piglets with normal and lowered blood pressure anaesthetized with propofol-remifentanil total intravenous anaesthesia

Abstract: BackgroundDuring anaesthesia and surgery, in particular neurosurgery, preservation of cerebral perfusion and oxygenation (CPO) is essential for normal postoperative brain function. The isolated effects on CPO of either individual anaesthetic drugs or entire anaesthetic protocols are of importance in both clinical and research settings. Total intravenous anaesthesia (TIVA) with propofol and remifentanil is widely used in human neuroanaesthesia. In addition, dexmedetomidine is receiving increasing attention as a… Show more

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Cited by 12 publications
(12 citation statements)
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“…186,[189][190][191] However, concurrent hypoxia or systemic hypotension may result in impaired cerebral oxygenation during Dex administration. 185,192 These results raise cause for caution with the use of Dex as part of an anesthetic for the patient with hemodynamic instability.…”
Section: Dexmedetomidinementioning
confidence: 99%
“…186,[189][190][191] However, concurrent hypoxia or systemic hypotension may result in impaired cerebral oxygenation during Dex administration. 185,192 These results raise cause for caution with the use of Dex as part of an anesthetic for the patient with hemodynamic instability.…”
Section: Dexmedetomidinementioning
confidence: 99%
“…Full study details and data regarding the entire study, and results regarding the effect of dexmedetomidine on CPO have been reported elsewhere [ 42 ] and are presented in Additional file 1 . The same animals were used for the study of vasopressor effect on CPO in this study.…”
Section: Main Textmentioning
confidence: 99%
“…The remaining 13 piglets reached the target MAP with vasopressor administration of > 130 mmHg or a 100% increase over pre-treatment MAP. The animals of the two groups revealed no significant demographic differences, nor were any significant differences revealed in anaesthesia time, preparation time, anaesthetic doses, baseline P br O 2 or LSPU measurements after equilibration [ 42 ]. Additionally, there was found no significant difference between the two groups in S br O 2 measured by NIRS (P = 0.59), which were 65% (range 59–72) in the LBP group and 62% (range 51–70) in the NBP group at PCB and PR-1 respectively.…”
Section: Main Textmentioning
confidence: 99%
See 1 more Smart Citation
“…Mai L G M et al proposed that propofol has rapid recovery and neuroprotection under total intravenous anesthesia, and is often used to awaken patients in brain functional area surgery. The study found that the duration and quality of arousal are often unsatisfactory, and it is easy to cause increased intracranial pressure due to asphyxia and agitation [11].…”
Section: Related Workmentioning
confidence: 99%