The Effect of Diethylenetriaminepentaacetic Acid (DTPA) on Acceleration of Excretion of Actinide Elements

Abstract

This study was set up to determine by whole-body counting the effectiveness of DTPA in hastening the excretion of americium (a) when the drug was given orally as compared to parenteral administration, (b) when treatment was delayed after various periods of time, and (c) when the radioisotope was deposited in the lungs. The experiment was stopped after 50 days. Oral treatment, while not as effective as parenteral treatment, was still surprisingly effective. The drug did significantly lower the body burden of the radioisotope deposited in the lungs.

Metabolism and Biological Effects of the Transplutonium Elements

“…Assuming that 3 and 4%, respectively, of the labeled surfaces of the bones of adult and growing rats is resorbed daily, the calculated amounts of nuclide remaining in bone agree with the amounts measured by FOREMAN (1962), SEIDEL and VOLF (1972), TAYLOR (1960), andSOWBY (1962), in which DTPA treatments were begun 6 to 14 days after nuclide injection and lasted for 7 to 23 days. In the studies of , .…”

“…At times longer than 1 to 2 days after nuclide injection, any nuclide that is still in the marrow has been deposited in bone, and nuclide initially only loosely bound at bone surfaces has become more firmly fixed. (FOREMAN, 1962;BELYAEV, 1969;SEIDEL and VOLF, 1972;NENOT et al 1971c; Table 30). Delayed DTPA treatment of 241 Am deposited in the bones of 7-week-old rats has been studied by SOWBY and TAYLOR (1960) and D.…”

“…The ICRP Task Group report (ICRP, 1966) was completed in mid-1965. At that time there was only one brief report of whole-body rentention of 241Am citrate administered intratracheally to rats (FOREMAN, 1962). In some very new studies beagle s have been exposed by inhalation to precisely-known 241 quantities of well~characterized particles of Am02 CR.…”

“…Similar lesions were apparently also induced by DTPA, but the dosages and severity of the lesions were not reported. However, there were no reports of grossly visible lesions in later studies in which as many as 50 daily doses of 0.46 roM/kg of DTPA were administered to rats (FOREMAN, 1962), or after a series of intermittent doses of 3 mM/kg of DTPA, totaling 27 mM/kg (D. M. TAYLOR and SOWBY, 1962). Amounts of DTPA ranging from 3 to 7 g/week have been tolerated by human beings under treatment for extended periods for removal of 239pu or 241Am (LAGERQUIST et al, 1967;FASrSKA et al, 1971).…”

Removal of Inhaled 241Am Oxide Particles of Various Sizes from Beagle Dogs Using Lung Lavage and Chelation Treatment

“…123 This relative solubility makes chelation of 24'Am with diethylenetriaminepentaacetate (DTPA) effective. A number of studies have demonstrated that 241Am can be removed from the body using DTPA or other chelating agents (Co74;L176;NC71;Fo62;Se73;Se75;Ta62;Ta66). DTPA has also been used to treat persons accidentally exposed to 241Am (Ha68: Co76).…”