The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis

Gao, Jianxin; Issekutz, Andrew C.

doi:10.1016/0192-0561(93)90016-r

Cited by 22 publications

(6 citation statements)

References 29 publications

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“…Additionally, due to their immunomodulatory properties [21], they have also been used in the treatment of autoimmune diseases, such as SLE [22] and rheumatoid arthritis [23]. Studies have revealed that NSAIDs inhibit the migration of leukocytes or their cytokine production, either cyclooxygenase (COX) dependently [24] or independently [25, 26], and thus exert immunomodulatory effects. In the present cases, since the increased activity of lymphocytes was mainly involved in the pathogenesis, the immunomodulation by the NSAID was thought to be responsible for the rapid removal of the symptoms and the complete remission of the disease.…”

Section: Discussionmentioning

confidence: 99%

Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions

Kazama

Sasagawa

Nakajima

2012

Case Reports in Medicine

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Two cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. Despite such symptoms that overlap with those of systemic lupus erythematosus (SLE), the diagnostic criteria for SLE were not fulfilled. Due to positive results for human parvovirus B19 (HPV-B19) IgM antibodies in the serum, diagnoses of HPV-B19 infection were made in both cases. Although acetaminophen failed to improve their deteriorating symptoms, a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen, completely removed the symptoms immediately after the administration. In those cases, since the patients were predisposed to atopic disorders, an increased immunological response based on the lymphocyte hypersensitivity was likely to be involved in the pathogenesis. The immunomodulatory property of NSAID was thought to repress such lymphocyte activity and thus provided a rapid and sustained remission of the disease.

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Section: Discussionmentioning

confidence: 99%

Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions

Kazama

Sasagawa

Nakajima

2012

Case Reports in Medicine

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“…Additionally, because of their immunosuppressive properties [ 35 ], they have also been used in the treatment of autoimmune disorders, including rheumatoid arthritis [ 36 ] and SLE [ 37 ]. According to previous studies, NSAIDs exert such immunosuppressive effects by inhibiting the leukocyte migration or their cytokine production, either in cyclooxygenase (COX)-dependent [ 13 ] or -independent manner [ 14 , 15 ]. In our patients, since the increased activity of lymphocytes was mainly involved in the pathogenesis, the immunomodulation by the NSAIDs was most likely responsible for the quick resolution of the symptoms and the complete remission of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…This study indicated the therapeutic usefulness of NSAIDs in the treatment of EBV infection. Additionally, besides their anti-inflammatory, antipyretic and analgesic properties, NSAIDs are also known to exert immunosuppressive properties by inhibiting the leukocyte migration or their cytokine production [ 13 – 15 ]. Here, we experienced two case of infectious mononucleosis induced by EBV in adult patients with atopic dermatitis or allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Drugs Quickly Resolve Symptoms Associated with EBV-Induced Infectious Mononucleosis in Patients with Atopic Predispositions

2016

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Case seriesPatient: Female, 24 • Male, 35Final Diagnosis: EBV-induced infectious mononucleosisSymptoms: Fever • general malaise • lymphadenopathyMedication: —Clinical Procedure: Physical examination and serological testingSpecialty: Infectious diseasesObjective:Rare co-existance of disease or pathologyBackground:Infectious mononucleosis is a clinical syndrome most commonly associated with primary Epstein-Barr virus (EBV) infection. In adults, the symptoms can often be severe and prolonged, sometimes causing serious complications. Analgesic or antipyretic drugs are normally used to relieve the symptoms. However, there is no causal treatment for the disease.Case Report:Two cases of adult patients with atopic predispositions developed nocturnal fever, general fatigue, pharyngitis and lymphadenopathy after an exacerbation of atopic symptoms or those of allergic rhinitis. Due to the positive results for EBV viral-capsid antigen (VCA) IgM and negative results for EBV nuclear antigen (EBNA) IgG, diagnoses of infectious mononucleosis induced by EBV were made in both cases. Although oral antibiotics or acetaminophen alone did not improve the deteriorating symptoms, including fever, headache and general fatigue, nonsteroidal anti-inflammatory drugs (NSAIDs), such as tiaramide or loxoprofen, completely improved the symptoms quickly after the initiation.Conclusions:In these cases, given the atopic predispositions of the patients, an enhanced immunological response was likely to be mainly responsible for the pathogenesis of the symptoms. In such cases, NSAIDs, that are known to reduce the activity of EBV, may dramatically improve the deteriorating symptoms quickly after the initiation. In the present cases, the immunosuppressive property of these drugs was considered to suppress the activity of lymphocytes and thus provide the rapid and persistent remission of the disease.

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“…14 Studies have reported that NSAIDs inhibit cytokine synthesis or migration of leukocytes, either COX dependently 29 or independently. 30,31 Since the primary pathogenesis of vaccine-related side effects is increased cellular immunity, it was thought that the immunosuppressive effect of NSAIDs was responsible for the faster reduction of fever, headache, and general fatigue. 32 myocarditis and pericarditis.…”

Section: Maximum Cortical Thickness Of Axillary Lymph Nodesmentioning

confidence: 99%

Effects of nonsteroidal anti‐inflammatory drugs on ultrasound findings of mRNA COVID‐19 vaccine‐related lymphadenopathy

Akman

Kaya

2022

J of Clinical Ultrasound

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Background Previous studies reported axillary lymphadenopathy (LAP) as a side effect of the anti‐COVID‐19 vaccine. However, the effects of nonsteroidal anti‐inflammatory drug (NSAID)s on mRNA COVID‐19 vaccine‐related LAP have not been investigated. Purpose We aimed to investigate the effects of NSAIDs on temporal changes in sonographic findings of COVID‐19 vaccine‐associated LAP. Methods Our single‐center retrospective cohort study was conducted between October 2021 and April 2022. We included patients (aged ≥ 18 years) who applied with complaints of swelling in the ipsilateral axillary region after the COVID‐19 vaccine and had axillary region ultrasound (US) scans in electronic medical records within 30 days pre‐vaccination. The serial US was performed on the third, 10th, and 30th days post‐vaccination. Results Our study included 38 patients with a median age of 36 (IQR, 32–43) years. In 18 (47.4%) patients used NSAIDs in the early post‐vaccination period. Measurements of LAPs on ultrasound scans increased at day 3 post‐vaccination compared with pre‐vaccination both in NSAID users and non‐users. On the 10th day, a statistically insignificant decrease in LAP diameters and cortical thickness was observed in NSAID users compared to non‐users. On the post‐vaccination 30th day, axillary LAPs regressed similarly in both groups. Conclusion In our study, post‐vaccine NSAID use had no statistically significant effect on the course of axillary LAPs.

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The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis

Cited by 22 publications

References 29 publications

Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions

Complete Remission of Human Parvovirus B19 Associated Symptoms by Loxoprofen in Patients with Atopic Predispositions

Nonsteroidal Anti-Inflammatory Drugs Quickly Resolve Symptoms Associated with EBV-Induced Infectious Mononucleosis in Patients with Atopic Predispositions

Effects of nonsteroidal anti‐inflammatory drugs on ultrasound findings of mRNA COVID‐19 vaccine‐related lymphadenopathy

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