The effect of erythropoietin against oxidative damage associated with reperfusion following ovarian detorsion

Sayyah-Melli, Manizheh; Rashidi, Mohammad-Reza; Kaseb-Ganeh, Mohaddeseh; Rashtchizadeh, Nadereh; Taghavi, Simin; Ouladsahebmadarek, Elaheh; Ghojazadeh, Morteza

doi:10.1016/j.ejogrb.2012.02.014

Cited by 12 publications

(6 citation statements)

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“…Ovarian ischemia is characterized by an increase in ovary size, ovarian hemorrhage, and venous congestion [ 1 – 3 ]. Adnexal torsion reduces blood flow, which results in an increase in lactic acid, hypoxanthine, and lipid peroxide levels, which can be measured in the blood [ 18 , 19 ]. Although de-torsion is usually applied as a treatment for adnexal torsion, it is followed by neutrophil infiltration activation and an increase in free oxygen radicals and cytokines, such as nitric oxide and tumor necrosis factor-α [ 18 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion

Atasever

Bakacak

2017

Med Sci Monit

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BackgroundThe aim of this study was to evaluate the effects of Nigella sativa (N. sativa) oil (NSO) on ovarian oxidative damage following ischemia-reperfusion injury, using a rat model of ovarian torsion.Material/MethodsForty-eight female albino Wistar rats were divided into six groups: (Group 1) laparotomy only; (Group 2) intraperitoneal NSO (2 ml/kg), 1 hour following laparotomy; (Group 3) 3 hours of ovarian ischemia; (Group 4) 3 hours of ovarian ischemia followed by 3 hours of reperfusion; (Group 5) 3 hours of ovarian ischemia and 2 ml/kg of NSO 1 hour before laparotomy; (Group 6) 3 hours of reperfusion after 3 hours of ovarian ischemia and 2 ml/mg of NSO 1 hour before laparotomy.ResultsThe antioxidant status, ceruloplasmin level, native thiol, total thiol, and disulfide levels of the control group (Group 1) were significantly increased compared with the ovarian ischemia-reperfusion group treated with NSO (Group 6) (p=0.003, p=0.002, p=0.006, p=0.001 and p=0.003, respectively); these levels in the ovarian ischemia group (Group 3) and ischemia-reperfusion group (Group 4) were statistically similar to those of the ovarian ischemia + NSO group (Group 5) and ovarian ischemia-reperfusion + NSO group (Group 6).ConclusionsIn this preliminary rat study, administration of NSO shortly after the onset of ovarian ischemia-reperfusion injury, did not significantly reduce levels of markers of oxidative injury. Further studies are required to evaluate the ovarian changes at the tissue level, and to determine the optimum dose of NSO.

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Section: Discussionmentioning

confidence: 99%

Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion

Atasever

Bakacak

2017

Med Sci Monit

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“…To prevent ovarian ischemia–reperfusion injury, numerous antioxidant drugs were tried in rat ovarian torsion-detorsion model. 7,21,22 Ozler et al demonstrated that ovarian reserve decreased following ovarian torsion-detorsion, and surgical detorsion alone was insufficient to protect ovarian reserve. 23 They revealed that antioxidant and anti-inflammatory treatment may contribute to conservative therapy in preservation of ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Colchicine on Ovarian Ischemia—Reperfusion Injury

Kurt

Doğan

et al. 2015

Reprod. Sci.

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“…5,18 Even with necrotic appearance ovarian tissue, detorsion procedure should be applied in patients whose desired fertility preservation. 19 However the ovarian tissue after detorsion procedure there is increase in production occurs neutrophil infiltration / activation, nitric oxide, cytokines such as TNF-α, and free oxygen radicals. In these cases ischemic damage lead to the formation of more tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary

Kirazoğlu¹,

Uyanıkoğlu²,

Incebiyik³

2017

Turkiye Klinikleri J Lab Anim

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dnexal torsion is the fifth leading cause of emergency gynecological surgery in spite of being seen rare. It is often seen in women with reproductive age, although it can be seen in prepubertal and postmenopausal period.1 Early diagnosis and treatment plays an important role in maintain the fertilization. Laparoscopy is a precise diagnosis and treatTurkiye Klinikleri J Lab Anim 2017;1(2):71-7 71Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Aim of this study is to evaluate the protective effect of dexmedetomidine on the histopathology and biochemical parameters in reducing damage in ischemia/reperfusion injury in rats ovary and to compare the effect of two different doses of dexmedetomidine. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty-two adult female Wistar Albino rats were used. Rats were separated into six groups: Sham, Torsion, Torsion+Detorsion, Torsion+Detorsion+Salin, Torsion+Detorsion+ Dexmedetomidine 10 µg/kg, and Torsion+Detorsion+Dexmedetomidine 20 µg/kg. Exception of the Sham group, ovarian torsion procedure was performed to all groups for 2 hours. Detorsion procedure was implemented to all groups for 2 hours, exception of Torsion group. Medications were given intraperitoneally half an hour before the detorsion procedure in Salin, Dexmedetomidine 10 µg and 20 µg groups. Then 2 mL of blood samples were drawn for markers of oxidative stress. The right ovaries were separated from all rats. R Re es su ul lt ts s: : The oxidative stress levels and histologic scores values of ovarian tissues were higher in Torsion+Detorsion group than in Sham group (p<0.001). By the uses of dexmedetomidine 10 and 20 µg, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores. C Co on nc cl lu us si io on n: : Administration of dexmedetomidine 10 µg and 20 µg are effective in preventing tissue damage by ischemia\reperfusion injury in ovarian torsion. However, there was no difference between the dexmedetomidine 10 µg and 20 µg treatments with regards to protective activity. K Ke ey yw wo or rd ds s: : Ovary; dexmedetomidine; reperfusion injury Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı rat overlerinde deneysel olarak oluşturulan iskemi\reperfüzyon hasarına karşı deksmedetomidin tedavisinin koruyucu etkinliğini değerlendirmek ve iki farklı deksmedetomidin dozlarını karşılaştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada 42 tane dişi Wistar Albino rat kullanıldı. Ratlar her biri yedişer rat olmak üzere 6 gruba ayrıldı: Sham opere, Torsiyon, Torsiyon-Detorsiyon, Torsiyon+Detorsiyon+ İzotonik sodyum klorür, Torsiyon-Detorsiyon+ Deksmedetomidin 10 µg ve Torsiyon-Detorsiyon+ Deksmedetomidin 20 µg. Sham opere grubu hariç diğer tüm gruplara iki saat boyunca ovaryan torsiyon işlemi uygulandı. Torsiyon grubu dışındaki diğer tüm gruplara 2 saat detorsiyon prosedürü uygulandı. Salin, Deksmedetomidin 10 µg ve Deksmedetomidin 20 µg gruplarında y...

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The effect of erythropoietin against oxidative damage associated with reperfusion following ovarian detorsion

Cited by 12 publications

References 30 publications

Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion

Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion

Protective Effect of Colchicine on Ovarian Ischemia—Reperfusion Injury

Protective Effects of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Ovary

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