2022
DOI: 10.37275/bsm.v6i6.534
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The Effect of Ethanol Extract of Kersen Leaf (Muntingia Calabura L.) on Reducing Triglyceride Levels in Hypercholesterolemic Rats

Abstract: Background: Kersen leaf has the potential to lower triglycerides because they contain flavonoids and tannins. Methods: This study was an experimental laboratory study with a pre and post-test with a control group design. The subjects were 30 white male rats (Rattus norvegicus), bodyweight ±200 grams, aged 3-4 months, and divided into 5 groups with random sampling. The groups were negative control (K-) was given a high-fat diet, and PTU without any treatment, positive control (K+) was given a high-fat die… Show more

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Cited by 2 publications
(4 citation statements)
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“…In comparison with these plants extracts, the extracts of Kersen leaves were considered more potent to inhibit the HMG-CoA reductase according to our present study. Some in vivo studies have been conducted using ethanol extract of Kersen leaves and found effective to reduce triglycerides and cholesterol levels in hypercholesterolemia rats at doses of 50 to 400 mg/kg of body weight (Putri et al, 2018;Ranti and Vickasari, 2022). The occurrence of alkaloids, flavonoids, phenolics, and steroids might promote the inhibitory effect on HMG-CoA reductase activity based on some in silico studies (Aqeel et al, 2018;Hariyanti et al, 2018;Shaik et al, 2020;Azmi et al, 2021;dan Mannino et al, 2021).…”
Section: Resultsmentioning
confidence: 99%
“…In comparison with these plants extracts, the extracts of Kersen leaves were considered more potent to inhibit the HMG-CoA reductase according to our present study. Some in vivo studies have been conducted using ethanol extract of Kersen leaves and found effective to reduce triglycerides and cholesterol levels in hypercholesterolemia rats at doses of 50 to 400 mg/kg of body weight (Putri et al, 2018;Ranti and Vickasari, 2022). The occurrence of alkaloids, flavonoids, phenolics, and steroids might promote the inhibitory effect on HMG-CoA reductase activity based on some in silico studies (Aqeel et al, 2018;Hariyanti et al, 2018;Shaik et al, 2020;Azmi et al, 2021;dan Mannino et al, 2021).…”
Section: Resultsmentioning
confidence: 99%
“…Keseluruhan hewan uji yang digunakan dalam penelitian diinduksi pakan tinggi lemak untuk mendapatkan kondisi hiperlipidemia. Campuran pakan dapat digunakan untuk memicu kondisi tersebut antara lain kuning telur, minyak kelapa, minyak samin, PTU, atau dengan pakan tinggi kalori dan lemak lainya [3], [19], [21]. Setelah diberikan perlakuan, sampel hewan uji akan dianalisis untuk mengetahui profil lipid maupun kondisi yang menunjukkan efektivitas kersen.…”
Section: Hasil Dan Pembahasanunclassified
“…Pada penelitian yang dilakukan oleh Ranti and Vickasari (2022), diketahui bahwa pemberian ekstrak etanol daun kersen dengan dosis 400 mg/kgBB/hari selama seminggu memberikan penurunan kadar trigliserida yang signifikan yaitu sebesar 60,02 mg/dL (p < 0,05) pada tikus hiperlipidemia [19]. Sejalan penelitian tersebut, Sopandi dkk.…”
Section: Hasil Dan Pembahasanunclassified
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