2017
DOI: 10.21873/invivo.11047
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The Effect of Geraniol on Liver Regeneration Αfter Hepatectomy in Rats

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Cited by 15 publications
(10 citation statements)
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“…In normal condition, hepatocytes and cholangiocytes stay in the G0 phase of the cell cycle and indicate minimal turnover, but in response to various stimulations such as toxic injury, infections, and LR, they proliferate to compensate for the lost cells, a process called liver regeneration [3,4]. Although the precise mechanism of liver regeneration is not well understood, extensive data from the literature have demonstrated that the immune system plays an important role in the initiation and termination of liver regeneration through pro-and anti-in ammatory mediators such as cytokines, complement, and chemokines [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…In normal condition, hepatocytes and cholangiocytes stay in the G0 phase of the cell cycle and indicate minimal turnover, but in response to various stimulations such as toxic injury, infections, and LR, they proliferate to compensate for the lost cells, a process called liver regeneration [3,4]. Although the precise mechanism of liver regeneration is not well understood, extensive data from the literature have demonstrated that the immune system plays an important role in the initiation and termination of liver regeneration through pro-and anti-in ammatory mediators such as cytokines, complement, and chemokines [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…Geraniol is another monoterpenoid valuable for the liver. This has shown regenerative effect in rats after partial hepatectomy . Eucalyptol and α ‐pinene, main monoterpenes of rosemary essential oil, according to Rašković, also exert hepatoprotective effects by diminishing AST and ALT activities …”
Section: Other Natural Monoterpene Biological Activitiesmentioning
confidence: 99%
“…According to hematoxylin and eosin staining and PCR results, GE exhibits a hepatoprotective effect in rats after a 70 % PH, as intraperitoneal administration of GE promoted liver tissue regeneration via improving the expression levels of TNF-α and IL-6. Also, GE remarkably suppressed the ALT level in serum, which regulates the function recovery of liver cells [47]. GE is a natural compound remarkably stimulating liver regeneration as shown in the rat model with a PH that was injected with GE 100 mg/kg.…”
Section: Antimicrobial Activitymentioning
confidence: 90%