The effect of graphene oxide (GO) on biomineralization and solubility of calcium hydroxyapatite (HA)

Zakharov, N. A.; Ткачев, А. Г.; Демина, Л. И.; Киселев, М. Р.; Калинников, В. Т.

doi:10.1134/s2070205116020337

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…Apparently, at higher GO@HEMA content, the number of nucleation sites increases, leading in the same time to a decrease in nanocrystal size because the growth process is diffusion-controlled. This type of effect induced by graphene nanofillers was reported previously and it was alleged that the predominant sites for HA nucleation are the edges and the fractures of GO flakes 46,47 . Another plausible explanation is that HA nucleation is influenced by rugosity 48 , and in our case the SEM results previously discussed revealed that surface roughness of the hybrid materials increases with GO@HEMA loading.…”

Section: Resultssupporting

confidence: 64%

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

Vasile

Pandele

Andronescu

et al. 2019

Sci Rep

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Poly(propylene fumarate) (PPF) is a linear unsaturated polyester which has been widely investigated for tissue engineering due to its good biocompatibility and biodegradability. In order to extend the range of possible applications and enhance its mechanical properties, current approaches consist in the incorporation of various fillers or obtaining blends with other polymers. In the current study we designed a reinforcing agent based on carboxylated graphene oxide (GO-COOH) grafted with 2-hydroxyethyl methacrylate (GO@HEMA) for poly(propylene fumarate)/poly(ethylene glycol) dimethacrylate (PPF/PEGDMA), in order to enhance the nanofiller adhesion and compatibility with the polymer matrix, and in the same time to increase the crosslinking density. The covalent modification of GO-COOH was proved by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA) and Raman spectroscopy. The mechanical properties, water uptake capacity, morphology, biodegradability, mineralization and in vitro cytotoxicity of PPF/PEGDMA hybrid materials containing GO@HEMA were investigated. A 14-fold increase of the compressive modulus and a 2-fold improvement in compressive strength were observed after introduction of the nanofiller. Moreover, the decrease in sol fraction and solvent swelling in case of the hybrid materials containing GO@HEMA suggests an increase of the crosslinking density. SEM images illustrate an exfoliated structure at lower nanofiller content and a tendency for agglomeration at higher concentrations. Finally, the synthesized hybrid materials proved non-cytotoxic to murine pre-osteoblast cells and induced the formation of hydroxyapatite crystals under mineralization conditions.

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Section: Resultssupporting

confidence: 64%

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

Vasile

Pandele

Andronescu

et al. 2019

Sci Rep

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“…Combining by van der Waals bonding was probably the most likely way, which resulted from the complex crystal structure of HA and folded surface morphology of graphene [ 54 ]. Zakharov et al studied interaction between graphene and HA, and found that HA/GO (graphene oxide) has lower thermostability compared with HA/CNT (carbon nanotube) [ 55 ]. Interaction between graphene and HA was based on the agglomeration of active OH groups in the HA nanocrystals formed on the surface and edges of graphene, causing the decrease of HA nanocrystal size and the increase of solubility [ 55 ].…”

Section: Interfacial Characteristics Of Titanium Alloy/ha Compositmentioning

confidence: 99%

“…Zakharov et al studied interaction between graphene and HA, and found that HA/GO (graphene oxide) has lower thermostability compared with HA/CNT (carbon nanotube) [ 55 ]. Interaction between graphene and HA was based on the agglomeration of active OH groups in the HA nanocrystals formed on the surface and edges of graphene, causing the decrease of HA nanocrystal size and the increase of solubility [ 55 ]. Besides, some researchers have shown that large increase of fracture properties is due to intense interfacial bonding from mechanical occlusion between graphene and matrix [ 54 ].…”

Section: Interfacial Characteristics Of Titanium Alloy/ha Compositmentioning

confidence: 99%

Research Progress Regarding Interfacial Characteristics and the Strengthening Mechanisms of Titanium Alloy/Hydroxyapatite Composites

Jiang

Shao

et al. 2018

Materials

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Titanium alloy/Hydroxyapatite (HA) composites have become a hot research topic in biomedical materials, while there are some challenges concerning bioactivity and mechanical properties such as low interface adhesion at the interface between metal and ceramic, complex interfacial reactions, and so on. Nevertheless, composites with reinforced phases can reach special properties that meet the requirements of biomedical materials due to the strong interfacial interactions between reinforcing phases (nano-carbon, partial oxides, and so on) and Titanium alloys or HA. This review summarizes the interface properties and mechanisms of Titanium alloy/HA composites, including interfacial bonding methods, strengthening and toughening mechanisms, and performance evaluation. On this basis, the interface characteristics and mechanisms of the Titaniumalloy/HA composites with enhanced phase are prospected. The results show that the interfacial bonding methods in the Titanium alloy/HA composites include chemical reactions and mechanical effects. The strengthening and toughening mechanisms contain grain refinement strengthening, second phase strengthening, solution strengthening, cracks and pulling out mechanisms, etc. This review provides a guidline for the fabrication of biocomposites with both mechanical properties and bioactivity.

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Effect of Fine‐Grained AZ91D Coating with Graphene Oxide/Hydroxyapatite on Biocompatibility

Song

et al. 2020

ChemistrySelect

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A graphene oxide/hydroxyapatite(GO/HA) composite coating were prepared on the surface of fine‐grained AZ91D magnesium alloy. The morphologies and structures of the coatings were characterized by Scanning Electron Microscopy and X‐Ray Diffraction. The corrosion behaviors were studied by polarization curve measurement and alternating current impedance spectroscopy, respectively. Also, the changes of the Mg2+ concentration in rat plasma were detected. Besides, changes of muscle, liver, and kidney in rats and bone in rabbit were tested to prove whether it was toxic to the body after implantation. Results showed that GO/HA‐AZ91D had good corrosion resistance. Compared to AZ91D, the corrosion potential, the membrane capacitance and the transfer resistance increased, the current decreased, and the corrosion performance was greatly improved. There was no significant difference of magnesium concentration among different groups. The structural characterization showed that the surface compactness of the composite coating was better, and the composite coating could effectively improve the corrosion resistance of the magnesium alloy.

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The effect of graphene oxide (GO) on biomineralization and solubility of calcium hydroxyapatite (HA)

Cited by 10 publications

References 19 publications

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials

Research Progress Regarding Interfacial Characteristics and the Strengthening Mechanisms of Titanium Alloy/Hydroxyapatite Composites

Effect of Fine‐Grained AZ91D Coating with Graphene Oxide/Hydroxyapatite on Biocompatibility

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