The Effect of Growth Hormone on the Healing of Experimental Bone Defects

Hz, Herold; Hurvitz, Avshalom; Tadmor, A.

doi:10.3109/17453677108989058

Cited by 29 publications

(12 citation statements)

References 1 publication

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“…For this we used 4-6 month-old rabbits. Such observations also reported by Herold, (1971) who was the first to described this model. The rabbit also is a well-established animal model in the field of BMP research (Zegzula et al, 1997;Texeira and Urist, 1998;Yuehuei and Friedman, 1999).…”

Section: In Vivo Evaluation Of the Osteoblast Seeded Cockle Shell-bassupporting

confidence: 60%

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Bakar¹,

Hussein²,

Mustapha³

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

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Section: In Vivo Evaluation Of the Osteoblast Seeded Cockle Shell-bassupporting

confidence: 60%

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Bakar¹,

Hussein²,

Mustapha³

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

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“…It was then placed in a prone position. Using a posterior approach, its forelimbs were incised longitudinally, the shaft of the radius was exposed and using a string saw, a 15-mm bone defect was created (Herold et al 1971). The periosteum of the bone defect area was completely removed and the skin and subcutaneous tissue were carefully sutured after inserting the autologous osteoblasts or bone-marrow-derived autologous MSCs combined with allogeneic cancellous bone granules.…”

Section: Formation Of the Bone Defectmentioning

confidence: 99%

Comparison of the osteogenic potentials of autologous cultured osteoblasts and mesenchymal stem cells loaded onto allogeneic cancellous bone granules

et al. 2011

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We compared the bone regeneration potentials of autologous cultured osteoblasts and of bone-marrow-derived autologous MSCs in combination with allogeneic cancellous bone granules in a rabbit radial defect model. Radial shaft defects over 15 mm were made in 26 New Zealand white rabbits. The animals underwent insertion of allogeneic cancellous bone granules containing autologous osteoblasts into right-side defects (the experimental group) and of allogeneic cancellous bone granules with autologous MSCs into left-side defects (the control group). To quantitatively assess bone regeneration, radiographic evaluations as well as BMD and BMC measurements were performed 3, 6, 9 and 12 weeks post-implantation and histology as well as micro-CT image analysis were performed at 6 and 12 weeks. Radiographic evaluations 3 weeks post-implantation showed that the experimental group had a higher mean bone quantity index (p < 0.05) and micro-CT image analysis showed that experimental sides had a greater mean total regenerated bone volume and surface area than the control sides (p < 0.05). Histologic evaluations obtained at 6 and 12 weeks revealed distinctly greater granule resorption and new bone formation in the experimental group. This in vivo study demonstrates that a combination of autologous osteoblasts and small-sized, allogeneic cancellous bone granules leads to more rapid bone regeneration than autologous MSCs and small-sized, allogeneic cancellous bone granules.

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“…It has therefore been hypothesised that GH may have a role in enhancement of fracture healing and a number of animal studies have demonstrated that GH stimulates bone formation (4-6), whereas others have shown no such response (36)(37)(38). This discrepancy has been explained by a variety of experimental designs used, the GH dosage and the animal species.…”

Section: Discussionmentioning

confidence: 91%

Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial

Raschke

Rasmussen²,

Govender³

et al. 2007

eur j endocrinol

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Objective: Investigate whether intervention with GH after tibial fracture enhances fracture healing. Design: Randomised, double-blind, placebo-controlled study in 406 patients (93 women, 313 men, age: 18-64 years) with tibial fracture. Methods: Patients were stratified by tibial fracture (open or closed) and allocated to placebo or GH treatment (15, 30 or 60 mg/kg daily, until clinically assessed healing or until 16 weeks post-surgery). Primary outcome was time from surgery until fracture healing and assessment of healing was done centrally and observer blinded. Patients reported for evaluation every 4 weeks until 24 weeks, and at 9 and 12 months.

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The Effect of Growth Hormone on the Healing of Experimental Bone Defects

Cited by 29 publications

References 1 publication

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Cockle Shell-Based Biocomposite Scaffold for Bone Tissue Engineering

Comparison of the osteogenic potentials of autologous cultured osteoblasts and mesenchymal stem cells loaded onto allogeneic cancellous bone granules

Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial

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