The effect of heat treatment on the morphology of D-Gun sprayed hydroxyapatite coatings

Erkmen, Ziya Engin

doi:10.1002/(sici)1097-4636(1999)48:6<861::aid-jbm15>3.3.co;2-8

Cited by 10 publications

(16 citation statements)

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“…The degree of HA crystallinity was evaluated according to the formula crystallinity = (X/Y) 100 (2) where X = net area of diffracted peaks, and Y = net area of diffracted peaks + background area [31]. Specific surface area measurements were undertaken using a Carlo Erba Sorpty 1750 instrument by measuring N 2 adsorption at 77 K and adopting the well-known Brunauer-Emmett-Teller (BET) procedure [37].…”

Section: Methodsmentioning

confidence: 99%

“…The broadening of the diffraction maxima indicated a relatively low degree of crystallinity, which was quantified according to previous methods (Table 1). [31] The crystal domain sizes along the c direction were calculated by Scherrer's formula (see Experimental section) using the 2h = 26°( 002) diffraction peak, and were 350 and 230 Å for HAns and Haps, respectively. The HAps diffraction pattern was very similar to that recorded for deproteinated bone apatite (Fig.…”

Section: Full Papermentioning

confidence: 99%

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Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Palazzo

Iafisco

Laforgia

et al. 2007

Adv Funct Materials

327

219

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This Full Paper investigates the adsorption and desorption of the anticancer drugs cis‐diamminedichloroplatinum(II) (CDDP, cisplatin) and the new platinum(II) complex di(ethylenediamineplatinum)medronate (DPM), as well as the clinically relevant bisphosphonate alendronate, towards two biomimetic synthetic HA nanocrystalline materials with either plate‐shaped (HAps) or needle‐shaped (HAns) morphologies and different chemico‐physical properties. The adsorption and desorption kinetics are dependent on the specific properties of the drugs and the morphology of the HA nanoparticles. Adsorption of the platinum complexes occurs with retention of the nitrogen ligands but the chloride ligands of cisplatin are displaced. Despite their opposite charges, the negatively charged alendronate bisphosphonate and the positively charged aquated cisplatin are strongly adsorbed, while the neutral DPM complex shows lower affinity towards the negatively charged apatitic surface. The data suggest that adsorption of the two platinum complexes is driven by electrostatic attractions, while interaction between the alendronate and the HA surface takes place by ligand exchange in which the two phosphonate groups of the drug molecule replace two surface phosphate groups. Significantly, adsorption of positively charged hydrolysis species of cisplatin is more favored on the phosphate‐rich HAns surface while adsorption of negatively charged alendronate is more favored on the calcium‐rich HAps surface. The latter type of short‐range electrostatic interactions also appear to dominate the desorption kinetics; consequently, drug release is greater for neutral DPM than for charged alendronate and aquated cisplatin. Moreover, while the release per unit area of charged species is the same for the two types of HAs, the release of DPM is faster from HAns, which is lower in surface calcium, than for HAps. Overall, this work demonstrates that the properties of HA nanocrystals can be modulated in such a way to produce HA/biomolecule conjugates tailored for specific therapeutic applications.

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Section: Methodsmentioning

confidence: 99%

Section: Full Papermentioning

confidence: 99%

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Palazzo

Iafisco

Laforgia

et al. 2007

Adv Funct Materials

327

219

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“…The samples were prepared using the front loading of standard aluminium sample holders which are 1 mm deep, 20 mm high ,and 15 mm wide. The degree of HA crystallinity was evaluated according to the formula [35]…”

Section: Structuralmentioning

confidence: 99%

“…and 2(d), respectively. The broadening of the diffraction maxima present in the X-ray diffraction patterns reported inFigures 2(a), 2(b), and 2(c) indicates a relatively low degree of crystallinity, which was quantified according to previous[35]. The degree of crystallinity of synthesized about 20 nm sized CHA nanocrystals with plate morphology and synthesized about 100 nm sized CHA nanocrystals with acicular (a) FTIR spectra of synthetic 20 nm sized CHA nanocrystals, (b) natural carbonate-hydroxyapatite from deproteined dentine.…”

mentioning

confidence: 96%

Surface Enamel Remineralization: Biomimetic Apatite Nanocrystals and Fluoride Ions Different Effects

Roveri

Battistella

Bianchi

et al. 2009

Journal of Nanomaterials

141

114

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A new method for altered enamel surface remineralization has been proposed . To this aim carbonate-hydroxyapatite nanocrystals which mimic for composition, structure, nanodimensions, and morphology dentine apatite crystals and resemble closely natural apatite chemical-physical properties have been used The results underline the differences induced by the use of fluoride ions and hydroxyapatite nanocrystals in contrasting the mechanical abrasions and acid attacks to which tooth enamel is exposed. Fluoride ions generate a surface modification of the natural enamel apatite crystals increasing their crystallinity degree and relative mechanical and acid resistance. On the other hand, the remineralization produced by carbonate-hydroxyapatite consists in a deposition of a new apatitic mineral into the eroded enamel surface scratches. A new biomimetic mineral coating, which progressively fills and shadows surface scratches, covers and safeguards the enamel structure by contrasting the acid and bacteria attacks.

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“…The amorphous to crystalline transition of the plasma-sprayed coatings of D-gun sprayed HA coatings occurred at nearly 5008C. 101,102 Presence of water vapor during postdeposition heat treatments plays an important role in increasing the CaP crystallinity. This observation was in concurrence with reports that indicate a significant increase in the crystallinity of plasma-sprayed HA coatings heated in the presence of water vapor as compared to HA coatings heated in air.…”

Section: Rf Sputteringmentioning

confidence: 99%

Calcium phosphate‐based coatings on titanium and its alloys

et al. 2007

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Use of titanium as biomaterial is possible because of its very favorable biocompatibility with living tissue. Titanium implants having calcium phosphate coatings on their surface show good fixation to the bone. This review covers briefly the requirements of typical biomaterials and narrowly focuses on the works on titanium. Calcium phosphate ceramics for use in implants are introduced and various methods of producing calcium phosphate coating on titanium substrates are elaborated. Advantages and disadvantages of each type of coating from the view point of process simplicity, cost-effectiveness, stability of the coatings, coating integration with the bone, cell behavior, and so forth are highlighted. Taking into account all these factors, the efficient method(s) of producing these coatings are indicated finally.

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The effect of heat treatment on the morphology of D-Gun sprayed hydroxyapatite coatings

Cited by 10 publications

References 0 publications

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties

Surface Enamel Remineralization: Biomimetic Apatite Nanocrystals and Fluoride Ions Different Effects

Calcium phosphate‐based coatings on titanium and its alloys

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