The Effect of High Concentration of Halothane on the Isolated Perfused Bovine Liver

Middleton, Michael D.; Roth, Gerald J.; Smuckler, Edward A.; Nyhus, Lloyd M.; virtue, robert

doi:10.1097/00132586-196702000-00017

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1970

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“…According to the experimental investigations of Hoech, Matteo and Fink (1966), a 2 per cent concentration of halothane diminished the consumption of oxygen by liver slices, but did not affect the rate of glycolysis. High (3 per cent) levels of halothane in the exchange gas mixture reversibly preclude the oxygen uptake by isolated perfused bovine livers (Middleton et al, 1966). In rat liver mitochondria!…”

Section: Discussionmentioning

confidence: 99%

Redox State of the Liver During Anaesthesia as Studied by Parenteral Galactose Loads in Children

Kekomäki¹,

Suutarinen²,

Mattila³

1970

British Journal of Anaesthesia

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The elimination rate of a parenteral dose of galactose, an indirect indication of the redox state of the liver hepatocytes, was determined in 46 children during anaesthesia and surgery. The anaesthetics used were thiopentone sodium, propanidid, halothane, diethyl ether, and nitrous oxide, administered in seven different combinations. The results suggest no direct involvement by any of the types of anaesthesia used in the liver redox system. Nevertheless, the normal oxidative metabolism may be affected indirectly by thiopentone-halothane combinations, unless an adequate alveolar ventilation is provided by appropriate measures.

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Section: Discussionmentioning

confidence: 99%