The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing

Yıldız, Şenol; Uluutku, Haldun; Günay, Alp; Yıldırım, İsmail Okan; Yıldırım, Şükrü; Gürbüz, Ahmet Kemal

doi:10.1097/00042737-200405000-00007

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…Second, octreotide has been shown to suppress the secretion of anabolic and tropic hormones such as pituitary growth hormone (GH), insulin‐like growth factor 1 (IGF‐1) and epidermal growth factor (EGF), all of which facilitate the wound‐healing process . An earlier work by Konturek et al .…”

Section: Discussionmentioning

confidence: 99%

Prophylactic octreotide for pancreatoduodenectomy: more harm than good?

McMillan

Christein

Callery

et al. 2014

HPB

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Section: Discussionmentioning

confidence: 99%

Prophylactic octreotide for pancreatoduodenectomy: more harm than good?

McMillan

Christein

Callery

et al. 2014

HPB

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“…20,25 Octreotide has also been shown to decrease the expression of ECM proteins, in particular collagen types I and III 30 and to decrease fibrosis during the progression of wound healing. 31,32 Our cultured HLECs expressed high levels of receptors for all 5 SSTRs including SSTR2, which is mainly targeted by octreotide. [33][34][35] We have been also able to detect SSTR2 in BLECs.…”

Section: Discussionmentioning

confidence: 99%

Octreotide inhibits growth factor–induced and basal proliferation of lens epithelial cells in vitro

Baldysiak-Figiel¹,

Jong‐Hesse²,

Lang³

et al. 2005

Journal of Cataract and Refractive Surgery

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The data show that, depending on the concentration, octreotide is able to decrease proliferative responses of LECs. Moreover, the cell proliferation induced by growth factors was potently inhibited by octreotide. Therefore, octreotide could be a potential drug after cataract surgery in prevention of growth factor-dependent proliferative disorders such as posterior capsule opacification and anterior capsule contraction in diabetic patients.

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“…Hyperbaric oxygen therapy treatment is a form of therapy in which patients are placed in a sealed chamber, and 100% oxygen is supplied intermittently at pressures above 1 ATA. Oxygen pressure must be above 1.4 ATA to be of therapeutic value (Hampson, 1999;Yildiz et al, 2004). In this study, patients were placed in multicompartmental chambers at a pressure of 2.5 ATA and a treatment time of 105-120 minutes.…”

Section: Methodsmentioning

confidence: 99%

The Efficacy of Hyperbaric Oxygen Therapy in Improving the Quality of Life in Patients With Problem Wounds

Lin

Yau²,

Lin³

et al. 2006

Journal of Nursing Research

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The unpredictable course followed by severe, chronic, non-healing wounds not only restricts the daily activities of affected patients, but also impairs their quality of life (QOL). Hyperbaric oxygen therapy (HBOT) treatment for such wounds elevates tissue oxygen content, increases cellular repair functions and the probability of wound healing, and improves the patient's QOL. This was a longitudinal, prospective study, and used a purposive sampling method. A total of 15 patients receiving HBOT at a medical center were enrolled. Data were collected by questionnaire before and after HBOT. The questionnaire included basic patient characteristics, self-perceived wound severity, wound physiological indices, and a QOL scale. The overall QOL score of the subjects after HBOT was higher than before HBOT. After HBOT, there was a positive correlation between the QOL of patients with problem wounds and the scoring of the Strauss wound classification system. After HBOT, there was a negative correlation between the QOL of patients with problem wounds and their self-perceived severity of the wound. The results were then used to provide suggestions for nursing care and additional research directions in order to effectively assist patients with problem wounds receiving HBOT, with the goal of achieving an optimal QOL.

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The effect of hyperbaric oxygen therapy on the adverse effects of octreotide on wound healing

Abstract: Hyperbaric oxygen therapy tends to reverse the octreotide-induced impairment of wound healing.

Cited by 10 publications

References 24 publications

Prophylactic octreotide for pancreatoduodenectomy: more harm than good?

Prophylactic octreotide for pancreatoduodenectomy: more harm than good?

Octreotide inhibits growth factor–induced and basal proliferation of lens epithelial cells in vitro

The Efficacy of Hyperbaric Oxygen Therapy in Improving the Quality of Life in Patients With Problem Wounds

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