The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer

Abstract

Lung cancer, which is mainly affected by environmental factors, is a lethal malignancy. It is also important to investigate the effect of genetic factors on lung cancer aetiology. In this study, we aimed to investigate the distribution of CYP1A1*2C, GSTT1 and GSTM1 polymorphisms in Turkish lung cancer patients to determine whether any promoting effect of polymorphisms could cause development of lung cancer. For this purpose, genomic DNA samples obtained from peripheral blood of 128 patients with lung cancer and 122 healthy subjects were analyzed. Genotyping of polymorphic enzymes were carried out by polymerase chain reaction-restriction fragment length polymorphism methods. Although there were no significant differences between groups in terms of CYP1A1 polymorphism, the carriers of CYP1A1 Ile/Val genotype (odds ratio [OR] = 1.224, 95% confidence interval [CI]: 0.585-2.564) or CYP1A1 Val/Val genotype (OR = 3.058, 95% CI: 0.312-30.303) had an increased risk of lung cancer development. There was no statistical difference between groups in terms of both GSTT1 null genotype (OR = 1.114, 95% CI: 0.590-2.105) and GSTM1 null genotype (OR = 0.776, 95% CI: 0.466-1.290). This is the first case-control study investigating CYP1A1 Ile/Val, GSTT1 and GSTM1 polymorphisms in Turkish lung cancer patients. Although we suggest that other genes in addition to the proposed genes could play a role in lung cancer development, the results of our study will contribute to the possible associations between CYP1A1 Ile/Val, GSTT1 and GSTM1 gene polymorphism on the risk of lung cancer.

CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) Polymorphisms and Bladder Cancer Risk in a Turkish Population

“…In contrast, the results of previous studies among Turkish population demonstrated increased risks for developing ovarian and prostatic carcinomas (Aktas et al, 2002;2004) but no association was detected with lung cancer (Atinkaya et al, 2012). The results of our study also did not reveal an increased risk of BC for CYP1A1 Ile 462 Val variant genotype.…”

Association between GSTM1 polymorphisms and lung cancer: an updated meta-analysis

“…However, individuals not exposed to these risk factors can also develop lung cancer, indicating that a difference in cancer susceptibility exists among individuals (Ada et al, 2012). Previous studies indicate that genetic polymorphisms in the glutathione S-transferase M1 (GSTM1) gene may affect the risk of lung cancer (Nakachi et al, 1993;Cao et al, 2004;Chen et al, 2004aChen et al, , 2012Atinkaya et al, 2012;Han et al, 2012;Li et al, 2012;Liang et al, 2012;Liu et al, 2012). Subjects who have inherited specific variants in the GSTM1 gene may be susceptible to the effects of chemical carcinogens and thus at a high risk of developing lung cancer.…”

CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

“…Recently, many investigators have reported association between CYP1A1 polymorphisms and cancers (Dai et al, 2009;Atinkaya et al, 2012;Lopez-Cima et al, 2012;Sergentanis et al, 2012;Ding et al, 2013), especially for two main functional polymorphic sites of CYP1A1 gene (MspI and Ile/Val) and cancer susceptibility. Previous studies (Kawajiri et al, 1990;Nakachi et al, 1991;Hayashi et al, 1992;Xu et al, 1996) have suggested that variant allele of CYP1A1 MspI polymorphisms is associated with malignancies, particularly lung cancer.…”