The effect of Diplotaenia turcica root extract in streptozotocin-induced diabetic rats

Abstract

BackgroundDiplotaenia turcica has been used traditionally to diabetes treatment. In this study, the effects of D. turcica root extract (DT) on diabetes mellitus induced by streptozotocin (STZ) were investigated.Materials and methodsIn this study, 78 male rats were used, rats were divided into 9 groups randomly. In diabetic groups, STZ was given a single dose of 45 mg/kg by intraperitoneally. DT (50, 100 and 200 mg/kg) and glibenclamide (5 mg/kg) were given by orally. Blood and pancreas tissue samples were taken for biochemical and pathological tests.ResultsIt was found that glucose levels decreased, and insulin levels increased in the treatment groups compared with the diabetes group. In addition, only in 200 mg/kg DT dose group was found to decrease HbA1c levels. Pancreatic tissue analysis showed that MDA levels decreased and GSH levels and CAT, SOD, GSH-Px and GSH-R activities increased in diabetic rats treated with DT. Histopathological and immunohistochemical examinations of the pancreas showed significant improvements in the treatment with DT.ConclusionThese results clearly show the antioxidant property of DT. The findings of this study showed that increased doses of DT may have a therapeutic effect on STZ-induced pancreatic damage.

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

“…In addition, it was determined that AST and ALT values increased in the cyclophosphamide-treated groups compared with the control group and decreased this increase in the gallic acid-treated groups. It was observed that SOD and CAT activities in liver tissues decreased in the groups treated with cyclophosphamide compared with the control group, and this decrease was improved in the groups where gallic acid was administered together with cyclophosphamide [ 30 ]. In a different study, the protective effects of gallic acid on the toxic effects of methotrexate were examined.…”

The antioxidant and antialzhemier activities of the Diplotaenia turcica with phytochemical analysis

“…Plants protect the cells against natural oxidation reactions due to the antioxidant substances they contain (Kähkönen Hopia Vuorela Rauha Pihlaja Kujala, Heinonen, 1999). DT is an endemic plant species growing in eastern Turkey Van-Bitlis-Hakkari (Özdek Yıldırım, Değer, 2020).…”

“…DT is an endemic plant species growing in eastern Turkey Van-Bitlis-Hakkari (Özdek Yıldırım, Değer, 2020).…”

“…In this respect, very little work has been done on Diplotaenia turcica plant. Earlier studies with the root part of Diplotaenia turcica plants was determined to be nontoxic and to have good antioxidant content (Özdek Yıldırım et al, 2020).…”

Antimicrobial, Antioxidant and DNA Damage Prevention Effect of Nano-Copper Particles Obtained from <i>Diplotaenia turcica</i> Plant by Green Synthesis

“…Diplotaenia turcica is an endemic plant that has existed for many years with a woody root structure of about 1.5-2 m long. Diplotaenia turcica, which blooms in white in August, is popularly known as "siyabo" [20]. Diplotaenia turcica plant is used by the people of the region in meals and treatments, as well as in the structure of herby cheese.…”