The effect of increased oxygen in acute limb ischaemia

Abstract

Acute hind‐limb ischaemia was produced in anaesthetized, ventilated dogs. During ischaemia the femoral venous oxygen tension fell markedly and both oxygen extraction and consumption appeared to increase. Oxygen at 2 ATA produced a relatively small increase in oxygen availability to the ischaemic tissues; femoral venous oxygen tension rose by 20 mm. Hg but oxygen extraction and consumption remained elevated.

Transdermal Sustained-Delivery Oxygen Improves Epithelial Healing in a Rabbit Ear Wound Model

“…Hyperbaric oxygen has been used extensively for more than 50 years in the treatment of ischemic wounds, largely on an empirical basis, and with a paucity of controlled clinical trials. [8][9][10][11][12] Nevertheless, in some studies, hyperbaric oxygen has shown some clear-cut benefits for wound healing, [13][14][15] and it has been accepted as an efficacious therapy for diabetic ulcers in the setting of ischemia. [16][17][18] With the recognition of oxygen as a signaling molecule, and experimental observations that intermittent hyperbaric oxygen can induce growth factors and their receptors 19 and enhance growth-factor activities, 20 there has been an increased understanding of the mechanism of action of hyperbaric oxygen therapy.…”