The effect of intraurethral dexpanthenol in hypospadias repair: experimental rabbit study

Karakan, Tarkan; Özcan, Serkan; Bağcıoğlu, Murat; Aydın, Arif; Doluoğlu, Ömer Gökhan; Yücel, Mehmet; Adalı, Yasemen; Yagli, Omer Faruk

doi:10.1016/j.jpurol.2019.04.003

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…A previous study by the current author group investigated the effect of intraurethral dexpanthenol in hypospadias repair and intraurethral dexpanthenol administration was found to significantly decrease inflammation and fibrosis. Similarly, in another study by the same group, intraurethral dexpanthenol was used in post-traumatic urethral stricture and was shown to reduce both inflammation and fibrosis 14,15 .…”

Section: Discussionmentioning

confidence: 89%

Effect of dexpanthenol on wound healing in penile fracture model: An experimental study

Yazar¹,

Doluoğlu²,

Ozgur³

et al. 2022

CIRU

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Objectives:In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days. Results: No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively). Conclusion: Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.

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Section: Discussionmentioning

confidence: 89%

Effect of dexpanthenol on wound healing in penile fracture model: An experimental study

Yazar¹,

Doluoğlu²,

Ozgur³

et al. 2022

CIRU

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“…90 The use of dexpanthenol was due to its activity for fibroblast stimulation in wound healing. 91 PVA/SA and PVA/SA films with amikacin were used for wound treatments, with amikacin cream as a positive control. 69 Histology on days 0, 7, 14, and 21 with hematoxylin-eosin (H&E) staining showed lower leukocyte infiltration in the groups treated with the films consisting of PVA/SA and PVA/SA/Amicacin, from the 7th day of wound healing, while the control group only showed similar responses after the 14th day.…”

Section: Wound Healing Activity Of Alginate/pva Composite Filmsmentioning

confidence: 99%

“…Dexpanthenol as a positive control in wound healing trials contributed significantly, relative to other treatment groups on the 7th and 10th day of the wound healing process 90 . The use of dexpanthenol was due to its activity for fibroblast stimulation in wound healing 91 …”

Section: Alginate and Pva: Physicochemical Characterization And Biome...mentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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“…Furthermore, the combination of treatments of ultrasound and DEX accelerated collagen fiber synthesis and organization in the early stages of cutaneous repair (Guimarães, Pires‐De‐Campos, Leonardi, Dib‐Giusti, & Polacow, ). Interestingly, administration of intraurethral DEX after hypospadias repair had positive effects on fibrosis and inflammation (Karakan et al, ).…”

Section: Vb5 and Wounds (Stitches)mentioning

confidence: 99%

The potential role of B5: A stitch in time and switch in cytokine

Gheita

Kenawy

2019

Phytotherapy Research

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The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel therapeutic strategies. Vitamin B5 (VB5), also known as pantothenate or "anti-stress vitamin," is the precursor of coenzyme A, which is essential in every micro-organism. Many pantothenic acid amides acquire persuasive antimicrobial activity. Pantothenic acid improves surgical wounds healing with moisturizing and skin barrier enhancing potential. Its deficiency leads to reduced cortisol production, increased arthritic pain, myalgia, fatigue, headache, depression, insomnia, and widespread "proinflammatory" effects on the immune-system. VB5 triggers immune cells to produce cytokines and is multifunctional. The paradoxical effect of VB5 on the switch of anti-inflammatory and proinflammatory cytokines has been revealed. This review aims to present the long research journey of B5 as it is becoming a forerunner in the healing of wounds and in enhancing the immune function, thus providing potentially important therapeutic implications. As its role in healing a wound stitch is promising, amending the immune system damage too is a hopeful target. KEYWORDSimmune system, pantothenic acid, rheumatic diseases, surgery, vitamin B5, wounds 2004;Pitari et al., 2000). Vanin-1 is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney.Its major function is related to its pantetheinase activity; vanin-1 breaks down pantetheine in cysteamine and pantothenic acid, a

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The effect of intraurethral dexpanthenol in hypospadias repair: experimental rabbit study

Cited by 6 publications

References 23 publications

Effect of dexpanthenol on wound healing in penile fracture model: An experimental study

Effect of dexpanthenol on wound healing in penile fracture model: An experimental study

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

The potential role of B5: A stitch in time and switch in cytokine

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