The Effect of Labetalol on the Hemodynamic Response to Endotracheal Intubation

BACKGROUND: Laryngoscopy and endotracheal intubation is invariable in G.A. and is associated with increased sympathomimetic response. The present study compared the efficacy of esmolol and labetalol in low doses for attenuation of pressor response. MATERIALS & METHODS:This is a Prospective, randomized, placebo controlled study in which 75 ASA Grade I and II patients aged 18-45 yrs. undergoing elective surgical procedures, requiring G.A. and orotracheal intubation were taken up for the study. Patients were allocated to any of the three groups of (25 each). Group C (Control) received 10ml of 0.9% saline IV, Group E (Esmolol) were given 1mg/kg of drug diluted with 0.9% saline 10ml IV, Group L (Labetalol) were given 0.5mg/kg of the drug diluted with 0.9% saline 10ml IV. All the patients were subjected to the same anesthesia technique. HR, SBP, DBP were recorded prior to intubation, then 1 minute, 3 min, 5 min and upto 10min post intubation. RESULTS: Compared to placebo, esmolol and labetalol significantly attenuated HR, SBP, DBP during laryngoscopy and intubation. CONCLUSION: In lower doses, labetalol is a better agent than esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation.

show abstract

Clinical Efficacy of Sciatic Nerve Block for Below-Knee Orthopaedic Surgeries

Hegde¹,

Manjunath²

2016

jemds

View full text Add to dashboard Cite

BACKGROUNDSciatic nerve block is a useful technique for unilateral lower limb surgeries. Many studies with different approaches for sciatic nerve block have been conducted to demonstrate the efficacy of sciatic nerve block with different local anaesthetic drugs over the past decades. Ropivacaine, a long-acting amide local anaesthetic is found to be a safe and effective agent of choice for sciatic nerve block. Hence, this observational study was undertaken to evaluate the clinical efficacy of sciatic nerve block for intraoperative anaesthesia and post-operative analgesia in patients undergoing below-knee orthopaedic surgeries.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Effect of Labetalol on the Hemodynamic Response to Endotracheal Intubation

Cited by 5 publications

References 0 publications

Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery

Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery

TO EVALUATE EFFECT OF IV ESMOLOL (1MG/KG) COMPARED TO I.V. LABETALOL (0.5MG/KG) IN ATTENUATING PRESSOR RESPONSE DURING LARYNGOSCOPY & INTUBATION IN GENERAL ANESTHESIA

Clinical Efficacy of Sciatic Nerve Block for Below-Knee Orthopaedic Surgeries

Contact Info

Product

Resources

About