The Effect of Lead Acetate and Quercetin on the Tight and Gap Junctions in the Mouse Testis

Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice

“… 23 A study reported that quercetin is found in M. pruriens seed and could improve junctional proteins and the integrity of the blood-testis barrier in mouse testis. 53 Such study even revealed the significant decrease of StAR and CYP11A1 expressions in mouse CUMS testis. It was in agreement with previous reports demonstrating that CUMS decreased the StAR and CYP11A1 expressions with increased corticosterone level.…”

LncRNA8276 primes cell–cell adhesion for regulation of spermatogenesis

“…[40][41][42] However, it has been noticed that the BTB and other testicular cell-cell junctions are predisposed to environmental toxicants, including cadmium, lead, aflatoxin, flutamide, bisphenol A, and even heat. 47,[63][64][65][66] The disruption of gap junctions at the BTB leads to a failure of coordination of tight junctions and anchoring junctions to impair the integrity of the immunological barrier. 47,[63][64][65][66] In our previous study we found that air toxicants NH 3 and/or H 2 S decreased sperm motility and concentration, and male fertility over a period of three generations.…”

“…47,[63][64][65][66] The disruption of gap junctions at the BTB leads to a failure of coordination of tight junctions and anchoring junctions to impair the integrity of the immunological barrier. 47,[63][64][65][66] In our previous study we found that air toxicants NH 3 and/or H 2 S decreased sperm motility and concentration, and male fertility over a period of three generations. 5,6 The impaired spermatogenesis by NH 3 and/or H 2 S may be due to the disruption in the testicular cell junctions following a reduction in the testicular protein levels of Cx43 and OCLN in three generations.…”

“…Moreover, the turnover of these junctions permits germ cells to translocate from the basal compartment to the adluminal compartment of the seminiferous epithelium to complete spermatogenesis 40–42 . However, it has been noticed that the BTB and other testicular cell–cell junctions are predisposed to environmental toxicants, including cadmium, lead, aflatoxin, flutamide, bisphenol A, and even heat 47,63–66 . The disruption of gap junctions at the BTB leads to a failure of coordination of tight junctions and anchoring junctions to impair the integrity of the immunological barrier 47,63–66 .…”

Selenium nanoparticles alleviate lead acetate‐induced toxicological and morphological changes in rat testes through modulation of calmodulin‐related genes expression

“…El‐Magd et al [ 8 ] showed that lead treatment in male rats significantly decreased sperm count, motility, viability, and increased sperm abnormalities along with degenerative changes in seminiferous tubules and Leydig cells and disturbance of the hormonal balance. Dolati et al [ 9 ] explained that lead exposure led to disorders in cellular interactions that maintain the integrity of the blood–testis barrier status leading to the affection of the testicular function. Also, Wahab et al [ 10 ] showed that lead acetate treatment of male rats significantly induces testicular oxidative stress leading to disruption of serum LH and testosterone levels, testicular 17β‐HSD activity, androgen receptor expression, sperm motility, viability, and counts.…”