The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice

Widiatmaja, Deandra Maharani; Lutvyani, Alif; Sari, Desi Rahmah; Kurniasari, Hamidah; Meiliana, Ismi Dian; Fasitasari, Minidian; Yamaoka, Yoshio; Rejeki, Purwo Sri

doi:10.1515/jbcpp-2021-0287

Cited by 11 publications

(4 citation statements)

References 38 publications

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“…When endogenous glucose production does not meet body's needs, ketogenesis begins to take over to provide an alternative energy supply (Sherrier & Li 2019). The absence of compensation in low glucose conditions causes a decrease in insulin and an increase in glucagon, which leads to increased ketogenesis (Widiatmaja et al 2021). Ketogenesis results in ketone bodies: acetyl CoA, β-hydroxybutyrate (βHB), and acetone, which lead to ketosis (Paoli 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin

Kurniasari

Rejeki

Kahar

et al. 2022

FMI

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Highlight:Adiponectin is an important protective factor for cardiovascular disease and increased insulin sensitivity.Ketogenic diet effect on adiponectin level in mice besides decrease weight gain was determined.The difference in serum adiponectin level and body weight is uncorrelated. Abstract:Ketogenic diet is a popular diet to reduce weight gain quickly. This diet has become a lifestyle . The ketogenic diet has been reported to affect adiponectin level, although it is still contraindicated. Adiponectin is a biomarker for metabolic disease that plays an important role as a protective factor for cardiovascular disease and increase insulin sensitivity. This study aimed to explore the effect of the ketogenic diet on adiponectin level in mice, besides decrease weight gain. This study was an experimental laboratory study with a randomized post-test-only control group design. Fourteen male mice (20-30 g) aged 2-3 months were divided randomly into K1 (n=7, standard diet) and K2 (n=7, ketogenic diet), were given diet for eight weeks, ad libitum. Body weight was measured at the pre and post-intervention, whereas adiponectin level were measured at the post-intervention using ELISA. The statistical analysis using SPSS version 16. The Shapiro Wilk test was used to determine normality, Independent T-Test was used to determine mean difference for normal distribution, Mann Whitney Test was used to determine mean difference for abnormal distribution, and Pearson Correlation was used to determine correlation. Difference (∆) of body weight on K1 (12.00±6.26) g, K2 (1.29±7.41) g with p=0.02. Serum adiponectin level of K1 (0.082±0.014) µg/ml and K2 (0.096±0.008) µg/ml with p=0.035. This study showed ketogenic diet-induced higher serum adiponectin level and slower weight gain. There is no correlation between the difference in body weight and serum adiponectin level (p=0.403).

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Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin

Kurniasari

Rejeki

Kahar

et al. 2022

FMI

Self Cite

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“…A study conducted on UK Biobank shows that diets high in fruits, vegetables, breakfast cereals, and dietary fiber, with a low intake of red meat and processed meat, are associated with a lower risk of lung cancer [83]. A long-term ketogenic diet increases serum adiponectin levels and does not affect serum IGF-1 levels [84].…”

Section: Adiponectin and Lung Cancermentioning

confidence: 99%

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Porro

Torre

Tartaglia

et al. 2022

Life

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Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology.

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“…Body Weight measurements were carried out pre-exercise and post-exercise for 4 weeks using a digital Harnic HL-3650 Heles Scale (0-5kg scale) (Widiatmaja et al, 2021;Rejeki et al, 2021). Meanwhile, Lee's obesity index for each mice was measured by dividing the cube root of the body weight (gr) by the naso-anal length (cm 2 )…”

Section: Data Collectionmentioning

confidence: 99%

Moderate-Intensity Swimming Exercises Decrease Body Weight and Lee’s Obesity Index in Female Mice (Mus musculus)

Antoni¹,

Rejeki²,

Sulistiawati³

et al. 2022

IJRP

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This study aims to analyze the effect of moderate-intensity swimming exercise which performed in the morning and at night on reducing body weight and Lee's obesity index in female mice (Mus musculus). This study used the true experiment method with the randomized control group post-test-only design. A total of 30 female mice (Mus musculus) at 3 months of age, and weighing 30 -40 grams (Lee's Obesity Index Value > 0.3) were divided randomly into three groups of 10, namely CTRL (n = 10, control without intervention), MISEM ( n = 10, moderate-intensity swimming exercise in the morning), and MISEN (n = 10, moderate-intensity swimming exercise at night). Body weight and Lee's obesity index was measured twice, namely preexercise and 4 weeks post-exercise. Then, data was analyzed using the Paired Samples T-Test with the Statistical Package for the Social Sciences SPSS version 21 software.The results show that the average body weight on CTRL between pre-exercise vs. post-exercise (33.60±2.17 vs. 39.20±3.82 gr (p-values=0.001)), )), and MISEN (33.40±3.47 vs. 26.00±2.26 gr (p-values=0.000)). Lee's average obesity index on CTRL between pre-exercise vs. post-exercise (0.39±0.02 vs. 0.44±0.02 gr/mm (p-values=0.000)), MISEM (0.40±0.02 vs. 0.42±0.01 gr/mm (p-values=0.000)), MISEN (0.41± 0.01 vs. 0.37±0.02 gr/mm (p-values=0.002)). Based on the results of the study, it was concluded that moderateintensity swimming exercise in the night was more effective in reducing body weight and Lee's obesity index than moderateintensity swimming exercise in the morning and control without intervention.

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The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice

Cited by 11 publications

References 38 publications

Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin

Effect of Long-Term Ketogenic Diet in Mice Serum Adiponectin

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Moderate-Intensity Swimming Exercises Decrease Body Weight and Lee’s Obesity Index in Female Mice (Mus musculus)

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