The effect of Matricaria chamomilla (chamomile) extract in Orabase on minor aphthous stomatitis, a randomized clinical trial

Tadbir, Azadeh Andishe; Pourshahidi, Sara; Ebrahimi, Hooman; Hajipour, Zohre; Memarzade, Mohammad Reza; Shirazian, Shiva

doi:10.1016/j.hermed.2015.05.001

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…In 14 out of 33 studies, adverse events were not reported (Andishe Tadbir et al, 2015; Arafa et al, 2018; Atanasovska Stojanovska et al, 2014; Babaee et al, 2012; Bratel et al, 2005; Deshmukh & Bagewadi, 2014; Eslami Raveshty & Eslami Raveshty, 2011; Garnick et al, 1998; Gavanji et al, 2014; Ghalayani et al, 2013; Jafari et al, 2003; Nasry et al, 2016; Samet et al, 2007; Tavangar et al, 2019). In another 15 studies, no significant adverse effects were reported and intervention was safe and well tolerated (Babadi & Nabhani, 2019; Babaee et al, 2010; Bhalang et al, 2013; Darakhshan et al, 2019; Du et al, 2018; Haghpanah et al, 2015; Hamdy & Ibrahem, 2010; Jiang et al, 2012, 2013; Kia et al, 2020; Manifar et al, 2012; Mansour et al, 2014; Pandya et al, 2017; Rodriguez‐Archilla & Raissouni, 2017; Seyyedi et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…The full text of the other 48 records were reviewed and 15 records were omitted due to the following reasons: duplicated data (n = 2), conference report (n = 2), review paper (n = 2), nonhuman clinical trials (n = 3), nonrandomized sampling (n = 2), and Chinese herbal medicine (n = 4). Finally, 33 records fulfilled the inclusion criteria and were carefully considered for data extraction (Amanlou et al, 2007; Andishe Tadbir et al, 2015; Arafa et al, 2018; Atanasovska Stojanovska et al, 2014; Babadi & Nabhani, 2019; Babaee et al, 2010; Babaee et al, 2012; Bhalang et al, 2013; Bratel et al, 2005; Darakhshan et al, 2019; Deshmukh & Bagewadi, 2014; Du et al, 2018; Eslami Raveshty & Eslami Raveshty, 2011; Garnick et al, 1998; Gavanji et al, 2014; Ghalayani et al, 2013; Haghpanah et al, 2015; Hamdy & Ibrahem, 2010; Jafari et al, 2003; Jiang et al, 2012, 2013; Kia et al, 2020; Kolseth et al, 2005; Manifar et al, 2012; Mansour et al, 2014; Nasry et al, 2016; Pandya et al, 2017; Pedersen et al, 1990; Raman et al, 2020; Rodriguez‐Archilla & Raissouni, 2017; Samet et al, 2007; Seyyedi et al, 2014; Tavangar et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

“…In comparison to the control group or placebo, in 22 studies, herbal agents significantly decreased the pain (Amanlou et al, 2007; Andishe Tadbir et al, 2015; Arafa et al, 2018; Atanasovska Stojanovska et al, 2014; Babadi & Nabhani, 2019; Babaee et al, 2010, 2012; Bratel et al, 2005; Darakhshan et al, 2019; Du et al, 2018; Gavanji et al, 2014; Ghalayani et al, 2013; Haghpanah et al, 2015; Hamdy & Ibrahem, 2010; Jiang et al, 2012, 2013; Manifar et al, 2012; Mansour et al, 2014; Nasry et al, 2016; Rodriguez‐Archilla & Raissouni, 2017; Seyyedi et al, 2014; Tavangar et al, 2019). In five studies, curcumin, quercetin, and multifora significantly decreased the pain of ulcer compared with baseline, however, its effect on pain did not significantly change compared with positive control groups (Deshmukh & Bagewadi, 2014; Jafari et al, 2003; Kia et al, 2020; Pandya et al, 2017; Raman et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Shavakhi

Sahebkar

Shirban

et al. 2021

Phytotherapy Research

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This systematic review was undertaken with the main aim of assessing the therapeutic effects of herbal medicines in recurrent aphthous stomatitis (RAS). A comprehensive search was performed in PubMed, Scopus, ISI Web of Science, and Google Scholar up to July 2021 to identify randomized clinical trials investigated the effects of herbal medicines on RAS. Thirty‐three papers comprising 2,113 patients met the eligibility criteria, of which 30 studies had a high quality based on the Jadad scale. Totally, 22 out of 30 studies which assessed the pain showed that herbal agents significantly decreased the pain compared with the control group or placebo. In 17 out of 25 studies that evaluated ulcer size, herbal agents significantly reduced the size of ulcers compared with the control or placebo groups. In 15 out of 18 studies that assessed the healing time, herbal agents significantly reduced healing time in the intervention groups compared with the placebo or control groups. Few adverse events were reported only in four studies. Findings of the current review indicated medicinal plants and phytochemicals as effective and safe agents that for the treatment of RAS.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Shavakhi

Sahebkar

Shirban

et al. 2021

Phytotherapy Research

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“…In an analysis of the effectiveness of a mouthwash containing 1% of Matricaria recutita extract in patients with gingivitis and fixed orthodontic appliances, the authors found that mouthwash had significantly reduced the rate of gingival bleeding after 15 days of treatment, compared with the placebo group. However, this reduction was similar to the group that used the 0.12% chlorhexidine and the difference between the groups was not significant [ 18 ].…”

Section: Discussionmentioning

confidence: 56%

Effects of Matricaria Recutita (L.) in the Treatment of Oral Mucositis

Gomes

et al. 2018

The Scientific World Journal

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Objective The objective of this study was to review the effects of the Matricaria recutita (L.) in the treatment of oral mucositis. Methodology The online search was performed in the period from June 2016 to April 2018 by means of databases LILACS (Latin American and Caribbean Center on Health Sciences Information), SciELO (Scientific Electronic Library Online), and MEDLINE (Medical Literature Analysis and Retrieval System Online). The consultation was restricted to the years 1991 to 2018 with the aim of elucidating the effects of Matricaria recutita in the treatment of oral mucositis. Results The final sample consisted of 21 studies, of which 10 were developed in animals and 11 in humans, published from 1991 to 2017, with a total sample of 644 patients. The total number of patients treated with Matricaria included in 11 studies was 364, while in the control groups the total number was 280. In experimental studies, animal models used were rats and the sample size ranged between 36 and 105 animals submitted to the induction of oral mucositis, where 4 studies used an intraperitoneal injection of 5-fluorouracil, while 7 induced lesion in the mucosa. From the data collected, it should be noted that both studies with humans and with animals showed significant effects. In this way, there is strong evidence for the discussion on the therapy; however, it should be noted that more studies are developed in order to clarify the most appropriate protocol for the prevention and treatment of injuries. Conclusion According to the results found in this study, Matricaria recutita appeared to be a promising alternative for the treatment of oral mucositis. However, due to the great variability in the various types of intervention, more controlled double-blind randomized clinical studies are necessary to ensure the best protocol for treating oral mucositis.

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“…Many researchers have reported that M. chamomilla has pharmacological properties, including antimicrobial (Batista et al, 2014), anti-inflammatory (Batista et al, 2014), antioxidative (Sebai et al, 2014), antispasmodic (Farideh et al, 2010), antiviral (Koch et al, 2008), and sedative (McKay and Blumberg, 2006) activities owing to the terpenoids, flavonoids (such as apigenin and luteolin), coumarins, and spiroethers in the plant (McKay and Blumberg 2006). Recently, it has been studied as a therapeutic agent against aphthous stomatitis (Tadbir et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Improved antioxidative and cytotoxic activities of chamomile (Matricaria chamomilla) florets fermented by Lactobacillus plantarum KCCM 11613P

Park

Bae

Eom

et al. 2017

J. Zhejiang Univ. Sci. B

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Abstract:Antioxidative and cytotoxic effects of chamomile (Matricaria chamomilla) fermented by Lactobacillus plantarum were investigated to improve their biofunctional activities. Total polyphenol (TP) content was measured by the Folin-Denis method, and the antioxidant activities were assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and β-carotene bleaching method. AGS, HeLa, LoVo, MCF-7, and MRC-5 (normal) cells were used to examine the cytotoxic effects by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. The TP content of fermented chamomile reduced from 21.75 to 18.76 mg gallic acid equivalent (mg GAE)/g, but the DPPH radical capturing activity of fermented chamomile was found to be 11.1% higher than that of nonfermented chamomile after 72 h of fermentation. Following the β-carotene bleaching, the antioxidative effect decreased because of a reduction in pH during fermentation. Additionally, chamomile fermented for 72 h showed a cytotoxic effect of about 95% against cancer cells at 12.7 mg solid/ml of broth, but MRC-5 cells were significantly less sensitive against fermented chamomile samples. These results suggest that the fermentation of chamomile could be applied to develop natural antioxidative and anticancer products.

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The effect of Matricaria chamomilla (chamomile) extract in Orabase on minor aphthous stomatitis, a randomized clinical trial

Cited by 23 publications

References 24 publications

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials

Effects of Matricaria Recutita (L.) in the Treatment of Oral Mucositis

Improved antioxidative and cytotoxic activities of chamomile (Matricaria chamomilla) florets fermented by Lactobacillus plantarum KCCM 11613P

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