The Effect of Medications on Thyroid Function Tests

Kundra, Priya; Burman, Kenneth D.

doi:10.1016/j.mcna.2012.02.001

Cited by 31 publications

(17 citation statements)

References 48 publications

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“…The first is worsening of hypothyroidism in patients under satisfactory treatment with thyroid hormone replacement. This effect was initially noted in patients under treatment with imatinib, but also other TKIs were found responsible for increase in LT4 supplementation in hypothyroid patients [98][99][100][101][102]. The second type of thyroid disturbance is primary hypothyroidism in patients with previously normal thyroid function.…”

Section: Tyrosine Kinase Inhibitorsmentioning

confidence: 90%

Thyroid Function Abnormalities in Patients Receiving Anticancer Agents

Torino¹,

Barnabei²,

Baldelli³

et al. 2012

Thyroid Hormone

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Section: Tyrosine Kinase Inhibitorsmentioning

confidence: 90%

Thyroid Function Abnormalities in Patients Receiving Anticancer Agents

Torino¹,

Barnabei²,

Baldelli³

et al. 2012

Thyroid Hormone

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“…We also examined whether the patient was treated with a drug that would significantly affect thyroid function from a predetermined list. There are many drugs that may affect thyroid function and only the most potent drugs have been tested, including glucocorticoids, levothyroxine, Mercaptizol, Propylthiouracil, Amiodarone, opioids and drugs that enhance T4 metabolism through the enhancement of cytochrome P450 3A4 such as phenytoin and carbamazepine ( 5 , 6 ).…”

Section: Methodsmentioning

confidence: 99%

Is routine measurement of TSH in hospitalized patients necessary?

Bashkin

Yaakobi

Nodelman

et al. 2018

Endocrine Connections

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TSH routine testing in hospitalized patients has low efficacy, but may be beneficial in a selected subgroup of patients. Our aim was to evaluate the efficacy of routine thyroid function tests among patients admitted to internal medicine departments. It is a retrospective study. A randomly selected cohort of hospitalized patients with abnormal thyroid-stimulating hormone (TSH) blood tests drawn as part of admission protocol. Patient data were collected from the electronic medical files and analyzed for its efficacy. TSH as a screening test was proven unnecessary in 75% (174) of the study population. Leading causes were non-thyroidal illness syndrome, drugs affecting the test results and subclinical disorders. TSH testing was found to be clinically helpful in only 9 patients; however, all of them had other clinical need for TSH testing. We found a clinically abnormal TSH in 20 patients, hypothyroidism in 11 patients and thyrotoxicosis in 9 patients. Low efficacy ascribed to TSH screening test by this study correlates with recent recommendations that indicate TSH screening in admitted patients only with accompanying clinical suspicion. Most probably, the majority of patients found by screening to have thyrotoxicosis have non-thyroidal illness or drug effects so the threshold for FT4 to diagnose overt thyrotoxicosis should be higher than that in ambulatory patients. In elderly patients, clinically relevant TSH disturbances are more frequent and are harder to diagnose, therefore, TSH screening in this group of patients might be beneficial.

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“…We recruited 191 candidates aged 20 years or older within 1 week before or after the first day of the 12 weeks of gestation from the outpatient obstetric clinic at Juntendo University Hospital, Tokyo, Japan, from December 2010 to December 2011. Based on the patients' medical records and answers to a health status questionnaire, we excluded women with established risk factors for fetal growth retardation such as multiple pregnancy, hypertension, congenital/acquired heart disease, diabetes mellitus, overt thyroid disease, and systemic diseases or medications known to affect thyroid function [12].…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%