The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

EL-Toweissy, Mona Y.; Mohamed, Nema A.; Abdel-Wahab, Wessam M

doi:10.1590/s1516-89132013000300007

Cited by 4 publications

(1 citation statement)

References 75 publications

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“…Another study showed that melatonin blunt the natural sympathetic arising of the first morning orthostatism and reduced the pressor effects of norepinephrine in pharmacological conditions . Yossef EL‐Toweissy et al study showed that the administration of melatonin and complex of vitamin B 1 , B 6 , B 12 following epinephrine injection partially improved the decreased body weight and liver glycogen levels.…”

Section: Interactions Between Melatonin and Catecholamines Regulationmentioning

confidence: 99%

The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review

Jafari‐Vayghan

Saleh‐Ghadimi

Maleki

et al. 2019

J of Cellular Biochemistry

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Heart failure (HF) is one of the prominent health concerns and its morbidity is comparable to many malignancies. Cardiac cachexia (CC), characterized by significant weight loss and muscle wasting, frequently occurs in progressive stage of HF. The pathophysiology of CC is multifactorial including nutritional and gastrointestinal alterations, immunological and neurohormonal activation, and anabolic/catabolic imbalance. Neurohormones are critically involved in the development of both HF and CC. Melatonin is known as an anti‐inflammatory and antioxidant hormone. It seems that melatonin possibly regulates the neurohormonal signaling pathway related to muscle wasting in CC, but limited comprehensive data is available on the mechanistic aspects of its activity. In this, we reviewed the reports regarding the role of neurohormones in CC occurrence and possible activity of melatonin in modulation of HF and subsequently CC via neurohormonal regulation. In addition, we have discussed proposed mechanisms of action for melatonin considering its possible interactions with neurohormones. In conclusion, melatonin likely regulates the signaling pathways related to muscle wasting in CC by reducing tumor necrosis factor α levels and activating the gene expression of insulin‐like growth factor‐1. Also, this hormone inhibits the proteolytic pathway by inhibiting nuclear factor‐κB (NF‐κB), renin‐angiotensin system and forkhead box protein O1 pathways and could increase protein synthesis by activating Akt and mammalian target of rapamycin. To elucidate the positive role of melatonin in CC and exact mechanisms related to muscle wasting more cellular and clinical trial studies are needed.

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Section: Interactions Between Melatonin and Catecholamines Regulationmentioning

confidence: 99%

The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review

Jafari‐Vayghan

Saleh‐Ghadimi

Maleki

et al. 2019

J of Cellular Biochemistry

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Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial

et al. 2020

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Vitamins B therapy in Regeneration of Peripheral Neuropathy Associated with Lipid Profile

AL-Saaeed¹,

Ali²,

Ali³

et al. 2019

J. Phys.: Conf. Ser.

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Objective: To investigate the role of serum lipid profile during the regeneration of experimental crush peripheral nerve injury to rats. Besides, to investigate which type of vitamin B therapy is better to accelerate the regeneration processes.Methods: Seventy-five male albino rats male, aged between 10 to 12 weeks were equally divided into 5 treated groups: B1, B6, B12, Tri-B complex and normal saline. Rats of therapeutic groups were administered according to the grouping and lasted to 45 consecutive days, and every 5 rats were sacrificed by euthanizing at 15th, 30th and 45th days. At dissection, sciatic nerve samples are taken from the site of crushed lesion and immersed in fixed formaldehyde 10%. 05 to 7 µm thick paraffin sections were stained by H&E and blood sample for lipid profile analysis.Results: The result showed no significant differences in serum lipid profile between therapeutic groups and control was found. Histological changes were shown on 15th days as, diffuse degeneration of the myelinated fibers with a marked vacuolization of some nerve fiber, numerous atrophic disoriented fibers with a large number of mononuclear phagocytes infiltration and degenerative debris. On 45th days there is a clear normal orientation of collagen fiber with very little debris and no vacuolization of the nerve. Morphometric measurements showed the myelin sheath thickness was increased significantly on the 30th and 45th days as compared with the control group. The result showed vitamin B12 is better in acceleration to nerve regeneration B12 groups showed better regenerative rate among other groups.Conclusion: no changes in serum lipid profile on experimental animals during regeneration processes. Vitamin B12 is better for enhancing the regenerative process.

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The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats

Cited by 4 publications

References 75 publications

The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review

The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review

Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial

Vitamins B therapy in Regeneration of Peripheral Neuropathy Associated with Lipid Profile

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