The Effect of Mineral Trioxide Aggregate on the Mineralization Ability of Rat Dental Pulp Cells: An In Vitro Study

<i>In vivo</i> evaluation of an experimental root-end filling material versus MTA

“…[8,9]. Rapid bone regeneration at 50 days in this study was confirmed by digital radiography densitometry, cone beam radiography, and histology.…”

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

“…For instance, the compressive strength of Biodentine (calcium silicates) was reported to be 49 MPa after 7 days, while Dycal (two-paste selfsetting calcium hydroxide) was only 16 MPa 21) . Compared to calcium hydroxide, MTA/calcium silicates produce more uniform and thicker dentin bridge formations with less inflammatory response and less necrosis of pulp tissue 22,23) , possibly due to its ability to increase bone morphogenetic protein (BMP-2 protein) production 24) and induce reparative dentinogenesis 25) . Many studies have demonstrated that MTA/calcium silicates were less toxic than calcium hydroxides.…”

“…Many studies have demonstrated that MTA/calcium silicates were less toxic than calcium hydroxides. In one study, MTA exhibited no cytotoxicity to rat dental pulp cells after 72 h, whereas the two-paste calcium hydroxide (Dycal) killed almost all cells 24) . Another study also suggested that calcium silicates (ProRoot MTA, MTA-Angelus (Angelus, Londrina, PR, Brazil), Biodentine) were less cytotoxic to odontoblasts cells than two-paste calcium hydroxide (Dycal) and one-paste calcium hydroxide (Calcicur) 8) .…”

Pulp Capping Materials Alter the Toxicity and Oxidative Stress Induced by Composite Resins in Dental Pulp Culture

“…While exposure of dental pulp cells to MTA has been shown to cause little toxicity, the current study shows that MTA can increase the toxicity of restorative materials (18 19). Conversely, Dycal is known to be toxic to dental pulp cells; however, this study demonstrates its potential protective effects against the toxicity of restorative materials (14,19,20). These results raise the possibility that the effectiveness of pulp capping materials may be partially determined by the type of restoration material applied.…”