The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance

Onopchenko, Oleksandra; Kosiakova, H. V.; Meged, E.F; Klimashevsky, Vitalii; Hula, N M

doi:10.15407/ubj86.06.119

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…The diet included pellets with addition of visceral lard. Component analysis of HFD [14] demonstrated that total content of fat, proteins and carbohydrates was 58, 23 and 10%, respectively. The fatty acids composition of HFD was at a ratio of 55% saturated (SFA) and 45% unsaturated (USFA) fatty acids.…”

Section: Methodsmentioning

confidence: 99%

The effect of N-stearoylethanolamine on adipocytes free cholesterol content and phospholipid composition in rats with obesity-induced insulin resistance

Dziuba¹,

Hudz²,

Kosiakova³

2018

Ukr.Biochem.J.

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Section: Methodsmentioning

confidence: 99%

The effect of N-stearoylethanolamine on adipocytes free cholesterol content and phospholipid composition in rats with obesity-induced insulin resistance

Dziuba¹,

Hudz²,

Kosiakova³

2018

Ukr.Biochem.J.

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“…Additionally, NSE modulated nitric oxide level (by affecting activi ty of constitutive and inducible NO synthases under different pathological conditions) [37] and reactive oxygen species level (by reducing the production of superoxide anion under LPS treatment) [38]. It worth to mentioning that effect of NSE is observed only under pathological conditions and does not show up under healthy normal conditions [39,40].…”

Section: Total Level Of Phospholipids and Level Of Individual Phosphomentioning

confidence: 99%

Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment

Horid’ko¹,

Kosiakova²,

Berdyshev³

2018

Ukr.Biochem.J

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The impairment of cognitive functions is the most studied medical and social problem nowadays. The aim of this study was to evaluate the protective effects of n-stearoylethanolamine (nSe) on memory state, blood and brain biochemical parameters in rats under scopolamine-induced cognitive impairment. The results of this study shown that nSe administration to rats per os (5 mg/kg, 5 days, during last 3 days nSe was administrated 20 min prior to scopolamine injection (1 mg/kg, once daily for 3 days, intraperitoneally)) prevented the development of memory impairment. In particular, NSe action was associated with the prevention of increase in acetylcholinesterase activity, changes in phospholipid, free and esterified cholesterol level in hippocampus and frontal cortex, and disruption in pro-/antioxidant balance in blood and studied brain sections. considering the above mentioned biological effects, nSe is a promising drug candidate for integrative therapy of cognitive impairment of different profiles.

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“…Meanwhile, the decrease of 20:4n-6 in the rat plasma may be related to activation of oxidative processes and synthesis of pro-inflammatory eicosanoides under IR conditions [30]. The increased amount of lipid and protein peroxidation products in the rat liver with experimental IR was found in our previous study [9,15].…”

Section: T a B L E 2 Content Of Total Lipids And Cholesterol Of Lipomentioning

confidence: 60%

“…The administration of NSE to rats with experimental IR causes normalization of 18:0 and 18:1n-9 FFA content in the rat plasma (Fig. 3) that correlates with the change of FFA composition in the liver of rats with IR [15].…”

Section: T a B L E 2 Content Of Total Lipids And Cholesterol Of Lipomentioning

confidence: 79%

“…Thus, we suggest that the high level of 18:1n-9 in the fat diet (Table 1) is one of the causes of increased VLDL level in IR group of rats. In the previous research we have fixed a considerab le compensatory increase of free cholesterol level as a result of the increased content of both free monoenoic FA (MUFA) and those in the composition of liver phospholipids from rats with obesity [9,15].…”

Section: Resultsmentioning

confidence: 99%

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The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

Onopchenko¹

2015

Ukr.Biochem.J.

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The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance

Cited by 6 publications

References 28 publications

The effect of N-stearoylethanolamine on adipocytes free cholesterol content and phospholipid composition in rats with obesity-induced insulin resistance

The effect of N-stearoylethanolamine on adipocytes free cholesterol content and phospholipid composition in rats with obesity-induced insulin resistance

Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment

The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

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