The effect of nanoparticle inclusion on the tensile and mode I fracture properties of polyimides

“…Interestingly, the presence of NP in native fi lms also leads to a signifi cant increase in mitochondrial activity, although not to the level of the cross-linked fi lms. NP additives have been shown to increase LbL fi lm rigidity, [ 47 ] and are shown here ( Figure 2 ) to increase LbL fi lm roughness. Since both substrate rigidity and roughness have previously been correlated with increased mitochondrial activity, [ 48 , 49 ] we conclude one of these two effects to cause the increase observed here.…”

Section: Resultsmentioning

confidence: 60%

Porous Nanofilm Biomaterials Via Templated Layer‐by‐Layer Assembly

Aslan

Gand³

et al. 2012

Adv Funct Materials

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Hydrogel‐like biomaterials are often too soft to support robust cell adhesion, yet methods to increase mechanical rigidity (e.g., covalent cross‐linking the gel matrix) can compromise bioactivity by suppressing the accessibility or activity of embedded biomolecules. Nanoparticle templating is reported here as a strategy toward porous, layer‐by‐layer assembled, thin polyelectrolyte films of sufficient mechanical rigidity to promote strong initial cell adhesion, and that are capable of high bioactive species loading. Latex nanoparticles are incorporated during layer‐by‐layer assembly, and following 1‐ethyl‐3‐[3‐dimethylaminopropyl]carbodiimide/N‐hydroxysulfosuccinimide (EDC‐NHS) cross‐linking of the polyelectrolyte film, are removed via exposure to tetrahydrofuran (THF). THF exposure results in only a partial reduction in film thickness (as observed by ellipsometry), suggesting the presence of internal pore space. The attachment, spreading, and metabolic activity of pre‐osteoblastic MC3T3‐E1 cells cultured on templated, cross‐linked films are statistically similar to those on non‐templated films, and much greater than those on non‐cross‐linked films. Laser scanning confocal microscopy and quartz crystal microgravimetry indicate a high capacity for bioactive species loading (ca. 10% of film mass) in nanoparticle templated films. Porous nanofilm biomaterials, formed via layer‐by‐layer assembly with nanoparticle templating, promote robust cell adhesion and exhibit high bioactive species loading, and thus appear to be excellent candidates for cell‐contacting applications.

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Nanofilm Biomaterials: Dual Control of Mechanical and Bioactive Properties

Pauthe

Tassel

2015

Layer‐by‐Layer Films for Biomedical Applications

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The effect of nanoparticle inclusion on the tensile and mode I fracture properties of polyimides

Cited by 16 publications

References 19 publications

Preparation, characterization and properties of amine-functionalized silicon carbide/polyimide composite films

Preparation, characterization and properties of amine-functionalized silicon carbide/polyimide composite films

Porous Nanofilm Biomaterials Via Templated Layer‐by‐Layer Assembly

Nanofilm Biomaterials: Dual Control of Mechanical and Bioactive Properties

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