The Effect of Niclosamide on Certain Biological and Biochemical Properties of Drosophila melanogaster

Üstündağ, Gökçe; Büyükgüzel, Kemal; Büyükgüzel, Ender

doi:10.26650/eurjbiol.2019.0003

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…That results are confirmed by Üstündağ and Buyukguzel [49] who indicated that niclosamide as one of salicylanilides exerted an oxidative stress and detoxification capacity on biological characteristics of the Drosophila melanogaster insect so nitroxynil could has the same effect.…”

Section: Locatelli Pedrosasupporting

confidence: 61%

“…The significant decrease in reduced glutathione (GSH) after nitroxynil therapy may be due to the effect of nitroxynil on small intestine that confirmed by the histopathological examination of duodenum showing several hemorrhages and inflammation because glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds that is synthesize in small intestine enterocytes inducing depletion in GSH and elicited an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and autophagy of the enterocytes [48]. Similarly, the significant decrease in GSH following nitroxynil treatment is matched with the decrease of GSH following niclosamide that belongs to the same salicylanilides group that have the same mode of action by uncoupling mitochondrial oxidative phosphorylation [49].…”

Section: Locatelli Pedrosamentioning

confidence: 99%

“…The higher values of these parameters may also be attributed to the more extensive reactions in the liver leading to higher risk of damage from oxidative stress and more limited antioxidant responses. Furthermore, anthelmintics as niclosamide and nitroxynil have an oxidative stress and caused many changes in lipid peroxidation product, malondialdehyde (MDA) and protein oxidation products that increased MDA contents [49].…”

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]mentioning

confidence: 99%

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Adverse effect of Nitroxynil and Albendazole on rabbits

Elalfy

Hassan

Amer

2021

Mansoura Veterinary Medical Journal

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The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1 st , 7 th and 14 th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results:The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.

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Section: Locatelli Pedrosasupporting

confidence: 61%

Section: Locatelli Pedrosamentioning

confidence: 99%

Section: Pedrosa De Bem [44]locatelli Pedrosa [45]mentioning

confidence: 99%

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Adverse effect of Nitroxynil and Albendazole on rabbits

Elalfy

Hassan

Amer

2021

Mansoura Veterinary Medical Journal

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“…It is known that nutrients available in the larval period are effective in all developmental stages of the insect [54]. For this purpose, the content and quality of artificial diets used for growing insects in the laboratory environment must be balanced [55][56][57][58][59]. Various antifungal, antibacterial, and antihelminthic agents are frequently used to improve diet quality.…”

Section: Discussionmentioning

confidence: 99%

Drosophila melanogaster Response to Feeding with Neomycin-Based Medium Expressed in Fluctuating Asymmetry

Büyükgüzel

Chudzińska

et al. 2020

Insects

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The fruit fly Drosophila melanogaster is a model species used for a wide range of studies. Contamination of Drosophila cultures with bacterial infection is common and is readily eradicated by antibiotics. Neomycin antibiotics can cause stress to D. melanogaster’s larvae and imagoes, which may affect the interpretation of the results of research using culture from neomycin-based medium. In the present study, fluctuating asymmetry (FA), one of the important bioindicators of stress, was measured. Larvae and imagoes of a wild-type D. melanogaster strain were exposed to various concentrations of neomycin. The size of anal papillae and selected wing veins were measured using scanning electron and light microscopy, respectively. Next, the FA was checked. The values obtained for larval anal papillae appeared to be concentration-dependant; the FA indices increased with the concentration of neomycin. The wing FA presented a large but variable correlation, depending on the measured vein. However, the mean length of veins was the highest for the control group, with neomycin-exposed groups showing lower values. The research showed that neomycin may cause sublethal stress in D. melanogaster, which manifests in increased FA indices. This suggests that neomycin can cause physiological and developmental stress in insects, which should be taken into account when interpreting the results of studies using these model organisms.

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Alteration in the oxidative status of Drosophila melanogaster Meigen (Diptera: Drosophilidae) fed with a diet containing Centaurea depressa M. Bieb. (Asteraceae)

Güneş

2020

Animal Biol.

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The aim of the this study was to evaluate the effects of fresh, dried and freeze-dried Centaurea depressa M. Bieb. (Asteraceae) on the oxidant and antioxidant status of the model organism D. melanogaster Meigen (Diptera: Drosophilidae) experimentally. The study was carried out from 2016 to 2019, and plant leaf extracts (0-50 mg/l) were added to insect standard artificial diets. The total protein, protein carbonyl content and glutathione-S-transferase, superoxide dismutase and catalase activities were quantified at the insect’s third larval stage. Our data showed that protein carbonyl content varied from 2.70 nmol/mg protein in the control group to 59.11 nmol/mg protein in the group fed with fresh leaf extract signifying induction of oxidative stress. All extracts increased the levels of all antioxidant enzymes and decreased the amounts of total protein. Meanwhile, the group fed with the freeze-dried extract showed no significant difference in the levels of total protein and protein carbonyl content except at the 50 mg/l concentration of the extract. Moreover, this group had superoxide dismutase and catalase activities 4 to 5 times higher than in the control group. In conclusion, induction of oxidative stress indicates that the fresh form of C. depressa leaves may have potential as a natural pesticide, whereas induction of endogenous antioxidant enzymes by the freeze-dried extract suggest its potential as an antioxidant.

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The Effect of Niclosamide on Certain Biological and Biochemical Properties of Drosophila melanogaster

Cited by 4 publications

References 39 publications

Adverse effect of Nitroxynil and Albendazole on rabbits

Adverse effect of Nitroxynil and Albendazole on rabbits

Drosophila melanogaster Response to Feeding with Neomycin-Based Medium Expressed in Fluctuating Asymmetry

Alteration in the oxidative status of Drosophila melanogaster Meigen (Diptera: Drosophilidae) fed with a diet containing Centaurea depressa M. Bieb. (Asteraceae)

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