The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case–control study

The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome

“…Therefore, we consider that this condition should be further discussed, and more comprehensive studies to enlighten the correlation between MPV, obesity, and PCOS are needed. Increased leucocyte count is an independent risk and prognostic factor in the development of inflammation and atherosclerosis [17], and there are several studies reporting increased leucocyte counts in patients with PCOS [4,7,15,16,35]. In our study, leucocyte counts were similar in patients with PCOS and controls; still, differential count of leucocytes revealed that patients with PCOS had higher neutrophil count and ratio, basophil count and lower lymphocyte count, compared to controls.…”

“…However, we failed to elucidate such an increase, and so further studies should be performed. In a study similarly designed to ours by Keskin Kurt et al, it was reported that higher hsCRP, leucocyte count, and NLR were present in PCOS patients [4]. Additionally, they also reported a moderate, but significant correlation among NLR and HOMA-IR, BMI, and hsCRP, reflecting the higher statistical power of their study.…”

“…Additionally, increased leucocyte counts were found to be an additional independent marker and prognostic factor in the development of inflammation and atherosclerosis [4,7,[15][16][17]. In recent years, neutrophil to lymphocyte ratio (NLR) has gained a popularity in the detection of inflammation in different inflammatory diseases such as PCOS, DM, ulcerative colitis, and hypertension, and it has been shown that NLR is correlated with hsCRP levels [4,18,19].…”

“…The characteristics of this syndrome are hirsutism, hyperandrogenism, menstrual disturbance, and infertility. Obesity, impaired glucose tolerance, insulin resistance, endothelial dysfunction, and increased inflammation are other well-known features [3][4][5][6][7]. Low-grade inflammation plays a key role in the development and progression of insulin resistance, type 2 diabetes mellitus (DM), and atherosclerosis [8][9][10].…”

Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development

“…Moreover, an association between infertility disorders and ASD has biological plausibility. All four disorders we found to be associated with ASD have been linked to inflammation and various autoimmune conditions (Vannuccini et al 2016; Tobias et al 2015; Kes-kin Kurt et al 2014; Bungum et al 2014; Kobayashi et al 2014; Ott et al 2014; Kachuei et al 2012; Horne and Critchley 2007; Confino and Radwanska 1992). Inflammation and auto-immunity have been implicated in ASD etiology as well (Ornoy et al 2016).…”