The effect of osteotomy dimension on osseointegration to resorbable media-treated implants: A study in the sheep

Galli, S.; Jimbo, Ryo; Tovar, Nick; Yoo, Doo-Yeol; Anchieta, Rodolfo Bruniera; Coelho, Paulo G.

doi:10.1177/0885328214553958

Cited by 17 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Utilizing a highly translational large animal model for this study and selecting the hip due to its low‐density bone configuration, in addition to its size, allowed for the placement of all experimental groups to be nested within each subject maximizing statistical power while minimizing the number of animals. In addition, this particular region was selected because it consists of a thin cortical layer and a marrow tissue, which is comparable to human bone .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Atemporal osseointegration: Early biomechanical stability through osseodensification

Alifarag

Lopez

Neiva

et al. 2018

Journal Orthopaedic Research

Self Cite

View full text Add to dashboard Cite

Osseointegration, the direct functional and structural connection between device and bone is influenced by multiple factors such as implant macrogeometry and surgical technique. This study investigated the effects of osseodensification drilling techniques on implant stability and osseointegration using trabecular metal (TM) and tapered-screw vent (TSV) implants in a low-density bone. Six skeletally mature sheep were used where six osteotomy sites were prepared in each of the ilia, (n = 2/technique: Regular [R] (subtractive), clockwise [CW], and counterclockwise [CCW]). One TM and one TSV implant was subsequently placed with R osteotomy sites prepared using a conventional (subtractive) drilling protocol as recommended by the implant manufacturer for low density bone. CW and CCW drilling sites were subjected to osseodensification (OD) (additive) drilling. Evaluation of insertion torque as a function of drilling technique showed implants subjected to R drilling yielded a significant lower insertion torque relative to samples implanted in OD (CW/CCW) sites (p < 0.05). Histomorphometric analysis shows that the osseodensification demonstrates significantly greater values for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Histological analysis shows the presence of bone remnants, which acted as nucleating surfaces for osteoblastic bone deposition, facilitating the bridging of bone between the surrounding native bone and implant surface, as well as within the open spaces of the trabecular network in the TM implants. Devices that were implanted via OD demonstrated atemporal biomechanical stability and osseointegration. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2516-2523, 2018.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the location has been previously used in studies with consistent outcomes . Additionally, using low bone density sites makes changes in bone density over time more apparent as well as it may simulate low bone density conditions such as osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Atemporal osseointegration: Early biomechanical stability through osseodensification

Alifarag

Lopez

Neiva

et al. 2018

Journal Orthopaedic Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the number of investigations concerning surgical instrumentation effects on early fixation and osseointegration is at least one order of magnitude smaller relative to other design parameters (Coelho and Jimbo, 2014). The limited body of literature addressing drilling technique and its effects on osseointegration suggests that implant stability can in fact be hastened by drilling protocol alterations in both maxillofacial and orthopedic settings (Galli et al, 2015a, 2015b; Giro et al, 2011, 2013; Sarendranath et al, 2015; Yeniyol et al, 2013). Specific to spine procedures, reviews in literature have primarily focused on the limited perspective of materials available to surgeons for clinical orthopedic applications (Rao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Osseodensification for enhancement of spinal surgical hardware fixation

Lopez

Alifarag

Torroni

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

Self Cite

View full text Add to dashboard Cite

Integration between implant and bone is an essential concept for osseous healing requiring hardware placement. A novel approach to hardware implantation, termed osseodensification, is described here as an effective alternative. 12 sheep averaging 65 kg had fixation devices installed in their C2, C3, and C4 vertebral bodies; each device measured 4 mm diameter×10 mm length. The left-sided vertebral body devices were implanted using regular surgical drilling (R) while the right-sided devices were implanted using osseodensification drilling (OD). The C2 and C4 vertebra provided the t=0 in vivo time point, while the C3 vertebra provided the t=3 and t=6 week time points, in vivo. Structural competence of hardware was measured using biomechanical testing of pullout strength, while the quality and degree of new bone formation and remodeling was assessed via histomorphometry. Pullout strength demonstrated osseodensification drilling to provide superior anchoring when compared to the control group collapsed over time with statistical significance (p < 0.01). On Wilcoxon rank signed test, C2 and C4 specimens demonstrated significance when comparing device pullout (p=0.031) for both, and C3 pullout tests at 3 and 6 weeks collapsed over time had significance as well (p=0.027). Percent bone-to-implant contact (%BIC) analysis as a function of drilling technique demonstrated an OD group with significantly higher values relative to the R group (p < 0.01). Similarly, percent bone-area-fraction-occupancy (BAFO) analysis presented with significantly higher values for the OD group compared to the R group (p=0.024). As a function of time, between 0 and 3 weeks, a decrease in BAFO was observed, a trend that reversed between 3 and 6 weeks, resulting in a BAFO value roughly equivalent to the t=0 percentage, which was attributed to an initial loss of bone fraction due to remodeling, followed by regaining of bone fraction via production of woven bone. Histomorphological data demonstrated autologous bone chips in the OD group with greater frequency relative to the control, which acted as nucleating surfaces promoting new bone formation around the implants, providing superior stability and greater bone density. This alternative approach to a critical component of hardware implantation encourages assessment of current surgical approaches to hardware implantation.

show abstract

“…When Oliveira et al tested whether OD method affected IPS in sheep's iliac crest, they discovered that it rose by approximately 60% in comparison to standard drilling [21]. Lahens This model is therefore ideally suited to assess the bone healing responses in low-density bone [22,23].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Osseodensification Versus Conventional Osteotomy Technique on Dental Implant Primary Stability: An Ex Vivo Study

Bandela¹,

Shetty²,

Munagapati³

et al. 2022

Cureus

View full text Add to dashboard Cite

One of the commonest treatment options for replacing missing teeth is a root-form implant. Clinically, the key mechanical factor in achieving success is primary stability. This ex vivo study aims to evaluate whether osseodensification method will achieve good primary stability or the conventional drilling protocol. MethodsFresh iliac bone of the sheep was selected similar to D3 and D4 bone densities. A total of 22 osteotomy sites were prepared in the bone sample, of which 11 were prepared by osseodensification method (test group) and other 11 by conventional undersized drilling (control group). Primary stability was measured using insertion torque (IT), resonance frequency analysis (RFA), and reverse torque values (RTVs) by measuring implant stability quotient (ISQ). The recorded data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) Version 22.0. The differences between groups were compared using the Mann-Whitney U test and independent t-test. The Pearson correlation coefficient test was performed to measure the linear relationship between two variables. The statistical significance level was established at p<0.05. ResultsWhen the correlation among IT, RTV, and ISQ was measured, a statistically significant correlation between IT and RTV (p=0.001) and between IT and ISQ (p=0.0001) was observed. A statistically significant (p=0.014) correlation between RTV and ISQ was also found. ConclusionOsteotomy prepared by osseodensification method showed higher IT, RTV, and ISQ values than the conventional undersized group.

show abstract

The effect of osteotomy dimension on osseointegration to resorbable media-treated implants: A study in the sheep

Cited by 17 publications

References 30 publications

Atemporal osseointegration: Early biomechanical stability through osseodensification

Atemporal osseointegration: Early biomechanical stability through osseodensification

Osseodensification for enhancement of spinal surgical hardware fixation

Comparative Evaluation of Osseodensification Versus Conventional Osteotomy Technique on Dental Implant Primary Stability: An Ex Vivo Study

Contact Info

Product

Resources

About