The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats

Aslan, Mine; Şentürk, Gözde Erkanlı; Akkaya, Hatice; Şahin, Sadık; Yılmaz, Bayram

doi:10.1016/j.tjog.2016.12.018

Cited by 38 publications

(40 citation statements)

References 18 publications

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“…In this study, we showed that prolonged hypoxia clearly damaged the endometrial and myometrial cells and these degenerative changes did not improve during the recovery period even after leaving the tissue in 100% oxygen for a long period, suggesting that irreversible damage to some uterine compartments took place. Our findings are consistent with previous studies in vivo which found severe degenerative endometrial changes with infiltration of leukocytes (including eosinophils) after prolonged ischemia in nonpregnant rats (Sahin et al 2014;Aslan et al 2017). Activated eosinophils were reported to release free radicals (Chanez et al 1990) and were implicated in epithelial damage (Yukawa et al 1990).…”

Section: Discussionsupporting

confidence: 93%

Hypoxic preconditioning ameliorates endometrial and myometrial damage and improves uterine function following prolonged hypoxia in nonpregnant rats

Alotaibi

2019

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Normal repeated uterine contractions are associated with uterine hypoxic stresses, and uterine transplantation and severe bleeding during hysterectomy may lead to hypoxia and irreversible cellular damage. This study investigated the effects of short repeated hypoxic episodes on the structure and function of uterine tissues following sustained prolonged hypoxia. Small segments of uterine tissue were dissected from three groups of nonpregnant rats and mounted in a tissue bath system. Prolonged hypoxia markedly increased the infiltration of eosinophils into the myometrium and caused fibrotic stroma and degeneration of endometrial glands with marked infiltration of eosinophils into the endometrium compared to the control group. In addition, the mean myometrial contractile function significantly decreased to 69 ± 1% compared to 100% control with irregular and uncoordinated contractile activity (p < 0.01). Intriguingly, preconditioning with brief hypoxic episodes prevented the endometrial and myometrial degenerative changes. Although the mean myometrial contractile function decreased to 80 ± 3% during reoxygenation compared to the 100% control, the entire force was greater than the force in the non-preconditioned group (p < 0.01). These results provide compelling evidence that prolonged hypoxia exacerbates the degree of cellular damage and that preconditioning with repeated cycles of short hypoxia/reoxygenation can ameliorate cellular damage.

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Section: Discussionsupporting

confidence: 93%

Hypoxic preconditioning ameliorates endometrial and myometrial damage and improves uterine function following prolonged hypoxia in nonpregnant rats

Alotaibi

2019

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“…Studies have been conducted on the effects of kisspeptin on the HPG axis and reproductive system in recent years (Dhillo et al., ; George et al., ; Kuohung & Kaiser, ). In recent years, studies have been carried out to determine whether this peptide has an antioxidant effect (Akkaya et al., ; Aslan et al., ; Aydin et al., ; Milton et al., ). A study by Akkaya, Eyuboglu, Erkanlı Senturk, and Yilmaz () on the testicular tissue has suggested that kisspeptin may reduce lipid peroxidation and may have antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

“…The decreased release of LH and FSH in hypothalamic dysfunction results in oxidative stress (Hurtado de Catalfo, Ranieri‐Casilla, Marra, De Alaniz, & Marra, ; Muthuvel et al., ). Recent studies have shown that kisspeptin protects against oxidative damage (Akkaya, Kilic, Dinc, & Yilmaz, ; Aslan, Erkanli Senturk, Akkaya, Sahin, & Yılmaz, ; Aydin, Oktar, Yonden, Ozturk, & Yilmaz, ; Milton, Chilumuri, Rocha‐Ferreira, Nercessian, & Ashioti, ).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats

Güvenç

Aksakal

2018

Andrologia

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The purpose of this study was to determine the kisspeptin-10 (Kiss) administration on the damages in testicular oxidant-antioxidant system, reproductive organ weights and some spermatological characteristics resulted from methotrexate (MTX) exposure. Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection. At the end of the study, malondialdehyde levels were found to have increased following the application of MTX while showing a significant reduction in group 4 with Kiss administration. With respect to the spermatological parameters, administering MTX decreased motility and increased the rates of abnormal spermatozoa in group 2, while improvements were observed in group 4 in the form of increased motility in the spermatozoa and fewer abnormal spermatozoa. In addition, Kiss treatment provided statistically significant increases in the absolute weight of the seminal vesicles and the relative weights of the right cauda epididymis and seminal vesicles resulting from MTX administration. MTX administration damaged some spermatological parameters and increased oxidative stress when compared to the control group. However, Kiss treatment was observed to mitigate these adverse effects as demonstrated by the improvements in coadministration of Kiss and MTX when compared to the MTX group. It is concluded that Kiss treatment may reduce MTX-induced reproductive toxicity as a potential antioxidant compound.

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“…Moreover, the protective contribution of OT aganist ischemia/reperfusion (I/R) injury has been demonstrated in the heart (11,12), ovary and uterus (9) and kidney and liver (10).…”

Section: Introductionmentioning

confidence: 99%

Does Oxytocin Have A Neuro-protective Impact in Rats’ Stroke Model?

Sayyed

Allah

Sherif

2019

BESPS

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Background: Stroke is a causative factor of disabilities and death. Various mechanisms involved in the cerebral ischemia-reperfusion pathophysiology, including oxidative stress along with inflammation. Aim: This research assessed the impact of oxytocin in lessening the detrimental effects of reperfusion in the cerebral ischemia/reperfusion (I/R) injury with the causal mechanisms. Materials: The cerebral ischemia-reperfusion injury was elicited by bilateral common carotid artery obstruction for 30 min followed by reperfusion for 24 h in rats. Forty eight rats were divided into: sham-operated group, oxytocin control group (underwent sham operation and given intraperitoneal oxytocin at a dose 750 µg/kg body weight), ischemia and reperfusion group and oxytocin-treated-ischemia and reperfusion group underwent I/R injury and given oxytocin 15 min before perfusion. Total antioxidant capacity, total peroxide, oxidative stress index, tumor necrosis factor-alpha and sodium/potassium-ATPase (Na + /K +-ATPase) level were measured in the cerebral homogenate. Histopathological analyses using H&E stain were carried out. Results: Administration of oxytocin lowered the ischemia-reperfusion-induced elevations in the cerebral total peroxide, oxidative stress index and tumor necrosis factor-alpha concentrations and increased total antioxidant capacity concentration and Na + /K +-ATPase level. Together, these changes were associated with alleviated histopathological alteration-induced by ischemia-reperfusion injury. Conclusion: Oxytocin has a neuro-protective impact against the deleterious effects of reperfusion via amelioration of oxidative stress, and inflammation and restoration of the declining level of the Na + /K +-ATPase. Thus, OT probably has a therapeutic impact on ischemic stroke.

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The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats

Abstract: The present results suggest that exogenous application of oxytocin and kisspeptin can have antioxidant effects on the uterus and ovary.

Cited by 38 publications

References 18 publications

Hypoxic preconditioning ameliorates endometrial and myometrial damage and improves uterine function following prolonged hypoxia in nonpregnant rats

Hypoxic preconditioning ameliorates endometrial and myometrial damage and improves uterine function following prolonged hypoxia in nonpregnant rats

Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats

Does Oxytocin Have A Neuro-protective Impact in Rats’ Stroke Model?

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