The effect of oxytocin on the urinary excretion of water and electrolytes in man

Cross, R. B.; Dicker, S. E.; Kitchin, A. H.; Lloyd, Sybil; Pickford, Mary

doi:10.1113/jphysiol.1960.sp006554

Cited by 20 publications

(9 citation statements)

References 15 publications

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“…of oxytocic activity) shows no activity, a result in agreement with those of other observers (Cross, Dicker, Kitchin, Lloyd & Pickford, 1960 Hyaluronida.e concentration. As found previously (Dicker & Eggleton, 1960), hyaluronidase could be detected in the urine at a relatively slow rate of flow, and its concentration was then more or less quantitatively related to rate of flow, as may be seen in Figs.…”

Section: Resultssupporting

confidence: 81%

Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Dicker¹,

Eggleton²

1961

The Journal of Physiology

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Section: Resultssupporting

confidence: 81%

Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Dicker¹,

Eggleton²

1961

The Journal of Physiology

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“…The 'other' posterior pituitary hormone, OT, has been shown to participate in the regulation of sodium balance in animals (23), but seemingly not in humans (24). However, few studies have measured OT in humans during exercise.…”

Section: Discussionmentioning

confidence: 99%

“…Although it is well documented that OT causes a natriuresis under physiological concentrations in male rats (23), evidence supporting a natriuretic effect of OT in humans is conflicting (24,28,29). OT, like AVP, can cause an antidiuresis in humans (30) that is likely mediated by vasopressin V2 receptors in the collecting duct of the kidney (31).…”

Section: Discussionmentioning

confidence: 99%

Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise

Hew‐Butler

Noakes²,

Soldin³

et al. 2008

European Journal of Endocrinology

100

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Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the potential contributions of other related endocrine factors, such as oxytocin (OT) and brain natriuretic peptide (BNP), have not been well described during exercise. Seven endurance-trained runners completed three separate running trials: a maximal test to exhaustion (high intensity), a 60-min treadmill run (steady state), and a 56 km ultramarathon (prolonged endurance exercise). Statistically significant pre-to post-run increases were found only following the ultramarathon in [AVP] p (1.9 vs 6.7 pg/ml; P!0.05), [OT] p (1.5 vs 3.5 pg/ml; P!0.05), [NT-proBNP] p (23.6 vs 117.9 pg/ml; P!0.01), [interleukin 6] p (4.0 vs 59.6 pg/ml; P!0.05), [cortisol] p (14.6 vs 32.6 mg/ml; P!0.01), [corticosterone] p (652.8 vs 3491.4 ng/ml; P!0.05) and [11-deoxycortisol] p (0.1 vs 0.5 mg/ml; P!0.05) while a significant post-run increase in [aldosterone] p was documented after high-intensity (4.9 vs 12.5 ng/ml; P!0.05), steady-state (6.1 vs 16.9 ng/ml; P!0.05) and prolonged endurance running (2.6 vs 19.7 ng/ml; P!0.05). Similarly, changes in fluid balance parameters were significantly different between the ultramarathon versus high-intensity and steady-state running with regard to plasma volume contraction (less % contraction), body weight loss (increased % weight loss), plasma

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“…An early study showed that i.v. infusion of oxytocin with a dosage ranging from 4 to 200 mU/min produced no measurable anti-diuretic effects and led to insignificant changes of urinary excretion of sodium (Cross et al 1960). On the other hand, another research group found an anti-diuretic effect in 15 out of 17 experiments using the same dosages of oxytocin (Thomson 1960).…”

Section: Anti-diuretic Action Of Oxytocinmentioning

confidence: 97%

Vasopressin-independent mechanisms in controlling water homeostasis

Cheng

Chu²,

Chow

2009

Journal of Molecular Endocrinology

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The maintenance of body water homeostasis depends on the balance between water intake and water excretion. In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term. A growing body of evidence from both in vitro and in vivo studies demonstrated that both secretin and oxytocin are involved as Vp-independent mechanisms regulating the renal water reabsorption process, including the translocation and expression of AQP2. This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis.

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The effect of oxytocin on the urinary excretion of water and electrolytes in man

Cited by 20 publications

References 15 publications

Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise

Vasopressin-independent mechanisms in controlling water homeostasis

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