The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells

Abstract

This work has demonstrated that paclitaxel can be effectively released from a biodegradable PLGA nanoparticle delivery system while maintaining potent combined cytotoxic and radiosensitizing abilities for hypoxic tumour cells.

Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells

“…In the previous work, we reported the radiosensitizing effect of paclitaxel-loaded nanoparticles on hypoxic tumor cells (41)(42)(43). Nevertheless, to our knowledge there are no studies on the literature regarding the cytotoxicity of paclitaxel-loaded nanoparticles on hypoxic tumor cells.…”

trans-[Ru(NO)(NH3)4(py)](BF4)3·H2O encapsulated in PLGA microparticles for delivery of nitric oxide to B16-F10 cells: Cytotoxicity and phototoxicity

“…However, the possibilities of controlling the NO release can be widened using also other drug delivery systems (DDS), such as microparticles. Microparticles have been used as drug delivery systems because they offer advantages such as a high stability, easy uptake into the cells by endocytosis, and targeting ability to specific tissues or organs by adsorption or coating with ligand materials at the surface of the particles [61][62][63][64][65][66][67]. Many biodegradable polymers are appropriate for making microparticles.…”

Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro

“…37,39,41 In a previous study, we reported the radiosensitizing effect of paclitaxel-loaded nanoparticles on hypoxic MCF-7 cells. 31 Nevertheless, to our knowledge there are no reports on the literature regarding the cellular uptake of paclitaxel PLGA nanoparticles.…”

“…23,24 Some studies on the use of nanoparticles as carriers for paclitaxel have been published. [25][26][27][28][29][30][31] Recently, paclitaxel has been reported to be successfully encapsulated in the pyromellitylimidoalanine-1, 6-bis(carboxy-phenoxy)hexane (PMA-CPH), PLGA microspheres and micellar nanoparticles as a radiosensitizer. 37,39,41 In a previous study, we reported the radiosensitizing effect of paclitaxel-loaded nanoparticles on hypoxic MCF-7 cells.…”

“…This was consistent with our previous study. 31 Due to the cytotoxicity of paclitaxel, the colony counts revealed that the colony numbers droped with the addition of free paclitaxel and paclitaxel-loaded nanoparticles with no radiation. Because the nanoparticles prevent the tumor cells from attaching, compared with cells only, the colony numbers droped with the addition of blank nanoparticles.…”