The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine

Devarakonda, Bharathi; Hill, Ronald A.; Villiers, Melgardt M. de

doi:10.1016/j.ijpharm.2004.07.006

Cited by 202 publications

(86 citation statements)

References 24 publications

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“…For example, PAMAM-OH G3 induced 3-fold and PAMAM-OH G2 2-fold increase in diffusion of CLO in comparison with hydrogel without PAMAM. The increase in generation number affects growth in size and number of primary and tertiary amines groups available for interaction with the drug and can be responsible for its dissolution enhancement in a vehicle, which in consequence can improve the in vitro release of the drug (Devarakonda et al, 2004). Additionally, to examine if diffusion of CLO from hydrogels depends on its molecular state, CLO was dissolved or dispersed in hydrogels with the most potent PAMAM-NH 2 G3 dendrimers.…”

Section: Resultsmentioning

confidence: 99%

PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state

Sosnowska¹

2013

Afr. J. Pharm. Pharmacol.

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Insufficient aqueous solubility of clotrimazole (CLO) is the main problem in designing pharmaceuticalformulations and limits its therapeutic efficiency. Polyamidoamine (PAMAM) dendrimers give the opportunity to decrease this limitation because of their solubilising and permeation enhancement properties. The aim of this study was to examine the influence of PAMAM dendrimers on the release of CLO from hydrogels and water suspensions. PAMAM dendrimers improved permeation of CLO from all analyzed formulations in the following order: PAMAM-NH 2 G3 > PAMAM-NH 2 G2 > PAMAM-OH G3 > PAMAM-OH G2. The effect evoked by PAMAM dendrimers was the most potent from hydrogels containing dissolved drug.

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Section: Resultsmentioning

confidence: 99%

PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state

Sosnowska¹

2013

Afr. J. Pharm. Pharmacol.

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“…Dendrimeric terminal end groups [10], dendrimer generation [11], dendrimer concentration and PH [12]. Dendrimer based solubilization is due to hydrophilic-hydrophobic interaction, ionic interaction and encapsulation of hydrophobic drugsinto crevices of dendritic architecture.…”

Section: Drug Loading In To the Pegylated Dendrimersmentioning

confidence: 99%

Biodistribution Study of Pegylated Ppi Dendrimer Loaded with Prednisolone for Prolonged Release

Karthikeyan¹,

O²,

rajKumar³

2017

Nano Res Appl

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PEGylated PPI dendritic scaffold was used for the delivery of an anti-leukemic drug, Prednisolone. The current study evolves and emerges the use PEGylated poly dendritic scaffold for the delivery of this drug. In this the prednisolone was loaded and synthesized with PEGylated PPI dendritic scaffold. Estimated the biodistribution of prednisolone in different vital organ was carriedout by HPLC method and the study was promising the distribution of drug candidate.

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“…Major applications are related to the drug delivery systems development (Gillies, Fréchet, 2005;Medina, El-Sayed, 2009;Nanjwade et al, 2009;Wijagkanalan, Kawakami, Hashida, 2011;, solubility (Devarakonda, Hill, Villiers, 2004) and biocompatibility improvements (reduce toxicity) (Duncan, Izzo, 2005;Sadekar, Ghandehari, 2010;Ciolkowski et al, 2012), magnetic resonance image (MRI) contrast (Wiener et al, 1994;Margerum et al, 1997;Kobayashi et al, 2003;Kojima et al, 2011;Tang et al, 2012), targeted drug delivery (Yang et al, 2009;Menjoge et al, 2011) and gene delivery (Dufès, Uchegbu, Schätzlein, 2005;Kim et al, 2007;Mintzer, Simanek, 2009;Shcharbin, Klajnert, Bryszewska, 2009;Nam et al, 2012).…”

Section: Dendrimers As a Platform For No Transportmentioning

confidence: 99%

Nitric oxide releasing-dendrimers: an overview

Roveda

Franco

2013

Braz. J. Pharm. Sci.

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Platforms able to storage, release or scavenge NO in a controlled and specific manner is interesting for biological applications. Among the possible matrices for these purposes, dendrimers are excellent candidates for that. These molecules have been used as drug delivery systems and exhibit interesting properties, like the possibility to perform chemical modifications on dendrimers surface, the capacity of storage high concentrations of compounds of interest in the same molecule and the ability to improve the solubility and the biocompatibility of the compounds bonded to it. This review emphasizes the recent progress in the development and in the biological applications of different NO-releasing dendrimers and the nitric oxide release pathways in these compounds.

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The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine

Cited by 202 publications

References 24 publications

PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state

PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state

Biodistribution Study of Pegylated Ppi Dendrimer Loaded with Prednisolone for Prolonged Release

Nitric oxide releasing-dendrimers: an overview

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