The effect of periodontal therapy on the improvement of glycemic control in patients with type 2 diabetes mellitus: A randomized controlled clinical trial

Abstract

AIMS:The purpose of this study is to investigate the effect of improved periodontal health on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have generalized periodontitis.MATERIALS AND METHODS:A total of 45 type 2 DM patients with generalized periodontitis were selected for the study. The selected patients were randomly assigned to three groups (groups A, B, and C) comprising 15 patients each: • Group A received treatment with scaling and root planing only. • Group B received treatment with scaling and root planing followed by systemic doxycycline. • Group C received no treatment (control group). The periodontal parameters recorded included plaque index, gingival index, probing pocket depth, and clinical attachment level. These parameters were recorded at baseline (day zero), at 1 month, and at the end of 3 months. The following metabolic parameters were recorded: fasting blood glucose (FBG), postprandial blood glucose (PPBG), and glycated hemoglobin. These were recorded at baseline (day zero) and at the end of 3 months.STATISTICAL ANALYSIS:All the parameters were subjected to repeated-measures ANOVA and Scheffe's post hoc test.RESULTS:A statistically significant effect could be demonstrated for periodontal parameters for both group A and group B (treatment groups). Glycated hemoglobin values showed statistically significant decrease in treatment groups compared to the control group, with group B showing more significant decrease than group A.CONCLUSIONS:The results of this study showed that nonsurgical periodontal treatment is associated with improved glycemic control in type 2 DM patients.

Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials

“…A significant decrease in the HbA1c level relative to the level in the control groupwas observed in the experimental groups (p＜0.001) 35) .…”

“…Singh et al 35) reported that significant changes in periodontal indices were observed in experimental groups A and B following the periodontal treatment (p＜0.001).…”

“…Meta-analysis for result estimation Table 1 summarizes the source, study design, participants, included factors, interventions, and results of the finally selected literatures 4,[34][35][36][37][38][39][40][41][42][43] .…”

The Effect of Bisphosphonates and Low-Dose Doxcycline Therapy in Diabetics With Periodontitis: A Review

“…121 The use of adjunctive systemic doxycycline to SRP therapy improved the periodontal parameters in uncontrolled type 2 DM patients compared to group SRP alone. 120,121 On the contrary, some of the studies did not significantly improve the results. 122,123,125 Moreover, the use of systemic doxycycline as adjunctive therapy in Type 1 DM patients with periodontitis did not improve levels of glycemic control.…”

“…95,103 The studies on type I and type II diabetic rats demonstrated that the non-antibiotic properties of TCs were effective in reducing the severity of a variety of abnormalities including (but not limited to) those in collagen structure, turnover and in bone remodeling (both locally in the oral tissues and systemically) that contribute to the pathogenesis of diabetic complications, such as unusually severe periodontitis. 118,119 Singh et al 120 study indicated that protein synthesis Atatürk Üniv. Diş Hek.…”