The effect of platelet-rich fibrin on autologous osteochondral transplantation: An in vivo porcine model

Sheu, Shi Yuan; Wang, C.H.; Pao, Yih‐Hsing; Fu, Yuan-Tsung; Liu, C.H.; Yao, Chun‐Hsu; Kuo, Tzong-Fu

doi:10.1016/j.knee.2017.08.049

Cited by 13 publications

(20 citation statements)

References 56 publications

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“…Often by passing the in vitro study phase, the pre-clinical implanting of PRF for cartilage repair has been evaluated by several Authors (Table 2). The hemocomponent was tested for the treatment of chondral [62,66,69,70,71,72], osteochondral [53,61,73,74,75,76] or meniscal [67] defects of the knee joint, as well as full-thickness cartilage defects of the ear [77]; the investigated animal models include rabbits [61,62,66,67,69,73,77], pigs [75], dogs [53,70,71,74,76] and horses [72].…”

Section: Prf In Cartilage Tissue Engineeringmentioning

confidence: 99%

“…Although PRF alone has been shown to positively influence cartilage repair in terms of the improvement of macroscopic and histological grading scores [70,71], most studies considered the possibility of implementing its regenerative potential by combining the implantation of the hemocomponent with (a) cartilage granules/fragments [66,69,75], (b) bone marrow-derived MSCs [53,72,74,76,77] and (c) the chemokine Stromal cell-derived factor (SDF)-1 [62]. In addition, PRF implantation was also investigated in association with other therapeutic strategies, such as suture repair of meniscal defects [67] and osteochondral autograft [73].…”

Section: Prf In Cartilage Tissue Engineeringmentioning

confidence: 99%

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Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Barbon

Stocco

Macchi

et al. 2019

IJMS

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Nowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Platelet-rich Fibrin matrices, have aroused widespread interest, acting as delivery platforms for growth factors, cytokines and immune/stem-like cells for immunomodulation; their autologous origin and ready availability are also noteworthy aspects, as safety- and cost-related factors and practical aspects make it possible to shorten surgical interventions. In fact, several authors have focused on the use of Platelet-rich Fibrin in cartilage and tendon tissue engineering, reporting an increasing number of in vitro, pre-clinical and clinical studies. This narrative review attempts to compare the relevant advances in the field, with particular reference being made to the regenerative role of platelet-derived growth factors, as well as the main pre-clinical and clinical research on Platelet-rich Fibrin in chondrogenesis and tenogenesis, thereby providing a basis for critical revision of the topic.

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Section: Prf In Cartilage Tissue Engineeringmentioning

confidence: 99%

Section: Prf In Cartilage Tissue Engineeringmentioning

confidence: 99%

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Barbon

Stocco

Macchi

et al. 2019

IJMS

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“…In contrast to rapid polymerization process in the presence of high thrombin concentration and thus, the rapid release of proteins from PRP in a day, slow and natural polymerization in PRF enables a continual and steady release of growth factors and cytokines from the fibrin graft in a 10-day period (12,36,37). Accordingly, PRF is the only autologous fibrin matrix with scaffolding properties, which releases growth factors continuously and slowly (17,(38)(39)(40), fulfils the 3 main criteria of acting as a scaffold, and contain living cells and growth factors simultaneously (13,29).…”

Section: Prf In Healıng and Regenerative Processmentioning

confidence: 99%

“…Thus, PRF is the ideal source of components for the recovery period with abundance of three main platelet cytokines (TGFβ-1, PDGF-BB, and IGF-1) (40-42) and a high potential for tissue repair that suits better to long-term release (12).…”

Section: Prf In Healıng and Regenerative Processmentioning

confidence: 99%

“…The rationale for use Original PRF is a gelatinous solid body that allows the use of PRF in orthopaedic surgery either directly as a bell-shaped clot (PRF matrix) or as a strong membrane after compression (PRF membrane) (40). PRF has been shown to be associated with an increase in osteoblast attachment and with proliferation and up-regulation of collagen-related protein production in in vitro quality assessment studies (12,14,(43)(44)(45)(46). Alongside its advanced biomechanical properties, this indicates its great potential to effectively promote bone regeneration (12,14,(43)(44)(45)(46).…”

Section: Use Of Prf In Orthopaedıc Surgerymentioning

confidence: 99%

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Plateletten zengin fibrinin iyileşme ve rejenerasyon sürecindeki rolü ve ortopedik cerrahide kullanımına dair bir derleme

Dülgeroğlu

Şen

2019

SDÜ Tıp Fakültesi Dergisi

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Available online at http://dergipark.gov.tr/sdutfd Makaleye http://dergipark.gov.tr/sdutfd web sayfasından ulaşılabilir. DERLEME REVIEW Med J SDU / SDÜ Tıp Fak Derg u 2019:26(3):354-361 AbstractPlatelet-rich fibrin (PRF) is a naturally derived fibrin scaffold and second-generation platelet concentrate. It has great potential for promoting wound healing and the regenerative process via the secretion of different cytokines and growth factors, enhanced osteoblast adhesion, and augmentation of collagen protein expression. Given the significance of the scope of PRF in the field of orthopaedic surgery, this study presents an overview for the role of PRF in the recovery and the regenerative process with emphasis on use in orthopaedic surgery. In conclusion, PRF offers a new dimension for clinical research with expanded range of potential applications in orthopaedic surgery. It seems to have a simpler preparation protocol, a stronger and more stable fibrin polymerization leading to a physiologic architecture, occurrence of natural clot formation allowing formation of a flexible and fine fibrin network and a continual and steady release of cytokines and growth factors, mimicking the requirements of the reparative tissue and wound healing processes.

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Double membrane platelet-rich fibrin (PRF) – Synovium succeeds in regenerating cartilage defect at the knee: An experimental study on rabbit

S¹,

Dirja²,

Utomo³

et al. 2023

Heliyon

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The effect of platelet-rich fibrin on autologous osteochondral transplantation: An in vivo porcine model

Cited by 13 publications

References 56 publications

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Plateletten zengin fibrinin iyileşme ve rejenerasyon sürecindeki rolü ve ortopedik cerrahide kullanımına dair bir derleme

Double membrane platelet-rich fibrin (PRF) – Synovium succeeds in regenerating cartilage defect at the knee: An experimental study on rabbit

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