2008
DOI: 10.1016/j.thromres.2007.09.012
|View full text |Cite
|
Sign up to set email alerts
|

The effect of polymorphisms of MTHFR C677T, A1298C, MS A2756G and CBS 844ins68bp on plasma total homocysteine level and the risk of ischemic stroke in Thai children

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
17
2

Year Published

2008
2008
2018
2018

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 19 publications
(23 citation statements)
references
References 29 publications
4
17
2
Order By: Relevance
“…Several independent studies have investigated the role of the MTHFR A1298C polymorphism in stroke risk (Table 1) (Akar et al, 2001;Linnebank et al, 2005;Sun et al, 2005;Komitopoulou et al, 2006;Sazci et al, 2006;Nan et al, 2007;Sirachainan et al, 2008;Biswas et al, 2009;Morita et al, 2009;Sawula et al, 2009;Chen et al, 2010;Han et al, 2010;Hultdin et al, 2011), but the results are inconclusive, partially because of the possible small effect of the polymorphism on stroke risk and the relatively small sample size in each of the published studies. To estimate the overall risk of the A1298C polymorphism for strokes, as well as to quantify the potential between-study heterogeneity, we performed a meta-analysis on all eligible published case-control studies.…”
Section: Introductionmentioning
confidence: 99%
“…Several independent studies have investigated the role of the MTHFR A1298C polymorphism in stroke risk (Table 1) (Akar et al, 2001;Linnebank et al, 2005;Sun et al, 2005;Komitopoulou et al, 2006;Sazci et al, 2006;Nan et al, 2007;Sirachainan et al, 2008;Biswas et al, 2009;Morita et al, 2009;Sawula et al, 2009;Chen et al, 2010;Han et al, 2010;Hultdin et al, 2011), but the results are inconclusive, partially because of the possible small effect of the polymorphism on stroke risk and the relatively small sample size in each of the published studies. To estimate the overall risk of the A1298C polymorphism for strokes, as well as to quantify the potential between-study heterogeneity, we performed a meta-analysis on all eligible published case-control studies.…”
Section: Introductionmentioning
confidence: 99%
“…Folic acid with vitamins B6 and B12 has been shown to be effective in reducing elevated homocysteine levels, but a recent review found no evidence to suggest that homocysteine-lowering interventions in the form of supplements of vitamins given alone or in combination should be used for preventing cardiovascular events (8).…”
Section: Discussionmentioning
confidence: 99%
“…1. Finally, eight case-control studies were included in the meta-analysis with a total number of 426 paediatric patients with AIS and 778 control subjects [12][13][14][20][21][22][23][24].…”
Section: Methodsmentioning
confidence: 99%
“…Caucasians were the most common race. In order to genotype the MTHFR 1298A>C polymorphism, PCR-RFLP analysis was used in four of the studies [12,13,20,21], CVD StripAssays in two studies [14,22] and Taqman PCR in one study [23]. The genotyping method was not specified in one of the studies [24].…”
Section: Study Characteristicsmentioning
confidence: 99%
See 1 more Smart Citation