The Effect of Prostaglandin Analogs and Prostamide on Central Corneal Thickness

Hatanaka, Marcelo; Vessani, Roberto Murad; Elias, I.R.; Morita, Celso; Susanna, Remo

doi:10.1089/jop.2007.0125

Cited by 37 publications

(51 citation statements)

References 18 publications

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“…Most of the recent studies have showed that prostaglandin analogues could decrease the central corneal thickness (CCT) values [13][14][15][16][17][18][19]. Lee and Cho [13] observed that latanoprost significantly reduced CCT in normal-tension glaucoma patients after 5 years of treatment.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Prostaglandin Analogues on Central Corneal Thickness

Duygu¹

2018

Int J Ophthalmol Clin Res

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• Page 1 of 6 • Uzunel. Int J Ophthalmol Clin Res 2018, 5:084 gested mechanism of IOP reduction involves aqueous humor outflow enhancement through the uveoscleral pathway accompanied by collagen degradation in the ciliary body. This collagen degradation is believed to be mediated by Matrix Metalloproteinases (MMPs) induced by prostaglandin F2-alpha [2,3]. Furthermore, because the cornea is mainly composed of collagen fiber [4], corneal thinning may be anticipated after pros-Elevated IOP is a risk factor for glaucoma and it's believed that to decrease the IOP values is the first choice of treatment in glaucoma [5]. Goldmann Applanation Tonometry (GAT) is known to be a standart method for IOP measurements however it's also well known that changes in Central Corneal Thickness (CCT) measurements may influence the GAT results accurate results of GAT are produced with a CCT of 520 mm, but CCT values higher or lower than 520 mm produces unreliable IOP measurements by over or under estimating of IOP values [6]. Besides its importance in IOP measurements it's also been suggested that CCT is an independent risk factor of progression in open angle glaucoma [7].The purpose of this study was to evaluate 5-year changes in the CCT in glaucoma patients treated with PG analogues monotherapy and to investigate the association between the CCT and the IOP in these patients. Material and MethodsMedical charts of 3696 glaucoma patients who have been followed up at Izmir Bozyaka Training and Research Hospital were reviewed retrospectively. Seventy-three eyes of 73 glaucoma patients constituted the glaucoma group and 75 eyes of 75 glaucoma-suspect patients constituted the control group. The inclusion

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Section: Resultsmentioning

confidence: 99%

The Effect of Prostaglandin Analogues on Central Corneal Thickness

Duygu¹

2018

Int J Ophthalmol Clin Res

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“…On the other hand, prolonged exposure to prostaglandin analogues seems to induce structural changes at the level of the corneal stroma, and numerous studies have revealed that chronic treatment with prostaglandins reduces central corneal thickness. 15,[19][20][21] This could also affect the results obtained when translated to the real situation of the treatment of patients with glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Effects of corneal thickness on the intraocular penetration of travoprost 0.004%

Martinez-de-la-Casa

Rayward

Saenz-Frances

et al. 2012

Eye

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Purpose To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness. Methods Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enroled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry. Results Mean AL-5848 concentrations were 3.27 ± 2.03 ng/ml in Group I (CCTo511 microns), 3.27 ± 2.44 ng/ml in Group II (CCTZ511 and r574 microns), and 2.73±2.15 ng/ml in Group III (CCT4574 microns), indicating no significant differences among the groups. Conclusions We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.

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“…The PGAs have also been shown to decrease the central corneal thickness (CCT) [6,[14][15][16][17][18][19][20][21], and because Goldmann applanation tonometry underestimates the IOP in eyes with thinner corneas [22][23][24][25], questions have arisen about the accuracy of the IOPs measured after the use of PGAs.…”

Section: Introductionmentioning

confidence: 99%

“…Although there are several studies on the effect of different PGAs on the CCT [6,[18][19][20][21], which PGA would reduce the CCT the most has not been determined.…”

Section: Introductionmentioning

confidence: 99%