The effect of right ventricular filling on the pressure-volume relationship of ejecting canine left ventricle.

Maughan, W L; Kallman, CH; Shoukas, Artin A.

doi:10.1161/01.res.49.2.382

Cited by 57 publications

(22 citation statements)

References 25 publications

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“…This observation is consistent with the leftward shift of the left ventricular end-systolic pressurevolume relation observed in isolated hearts when right ventricular volume was increased, i 3 -24 - 39 Left ventricular systolic pressure has been observed previously to increase after sudden constriction of the pulmonary artery during the preceding diastole. 28 Although repeated determinations of the endsystolic pressure-volume relation have been shown recently to be subject to significant variability, 40 this variability cannot account for the consistent, unidirectional shift (i.e., increase) in the end-systolic LV END-DIASTOLIC VOLUME (ml) FIGURE …”

Section: Figure 3 Mean Developed Left Ventricular (Lv) Ejection Pressupporting

confidence: 86%

Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Feneley

Olsen

Glower

et al. 1989

Circulation Research

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Section: Figure 3 Mean Developed Left Ventricular (Lv) Ejection Pressupporting

confidence: 86%

Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Feneley

Olsen

Glower

et al. 1989

Circulation Research

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“…In addition, the studies that were previously done only describe whole right and left ventricular pressure-volume curve shifts, indicating that the intraventricular pressure of the left ventricle has a pericardial component that increases at higher intraventricular volumes and/or pressures (9,12,15,35). Unlike previous investigations, our study describes how the pericardium directly affects the pressure and volume information transfer between the ventricles, i.e.…”

Section: Discussionmentioning

confidence: 65%

“…The effect of the developing pericardium on ventricular interaction is not known. Studies of adult hearts enclosed by the pericardium and having a relatively more compliant right than left ventricular free wall have indicated that the pericardium enhances ventricular coupling (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Furthermore, other adult studies suggest that the pericardium may grow or adapt to increased volume loads imposed on the myocardium (1 7, 19-2 1).…”

mentioning

confidence: 99%

Pericardial Effects on Diastolic Ventricular Interaction during Development

et al. 1990

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ABSTRACT. The effects of the pericardium on myocardial diastolic ventricular interaction during early development were determined in vitro using hearts excised from eight preterm (109 f 0.106 SE d gestation; term = 147 d) and eight newborn (2.3 + 0.30 SE d postnatal age) lambs. The lamb hearts were excised with the pericardium intact and immersed in a cold cardioplegic solution. Subsequently, very compliant balloon catheters were inserted into the right and left ventricles retrograde through the pulmonary artery and aorta respectively. Before and after the removal of the pericardium, the changes in left ventricular pressure or volume caused by increasing right ventricular pressure or volume were measured. Computerized analysis of the pressure and volume recordings yielded pressure and volume transfer functions that quantified ventricular interaction. The pressure transfer functions (left ventricular pressure/right ventricular pressure) both with and without the pericardium intact were 0.297 f 0.010 SE and 0.140 f 0.005 SE, respectively, for the preterms and 0.650 + 0.033 S E and 0.301 f 0.031 SE for the newborns. The volume transfer functions (left ventricular volume/right ventricular volume) with and without the pericardium were 0.320 f 0.04 SE and 0.150 f 0.024 SE, respectively, for the preterm and 0.514 f 0.052 SE and 0.233 f 0.027 S E for the newborns. These data demonstrate that 1 ) the pericardium increases ventricular interaction in both preterm and newborn lambs and 2) the relative percentage increase is similar for both age groups and not age dependent. Furthermore, these findings suggest that the increase in ventricular interaction due to the presence of the pericardium is mediated by the relative compliances of the free walls, septum, and pericardium. through the myocardium, independent of neural, circulatory, or humoral effects, is termed ventricular interaction (1-3).Previous in vitro investigations have demonstrated age-related differences in diastolic ventricular interaction in the absence of the pericardium (4). These differences in interaction were attributed to a difference in the relative compliances of the interventricular septae between preterm and newborn lamb hearts. In a previous study (4), no difference was demonstrated between the free wall compliances of the right and left ventricular free walls of either group. The effect of the developing pericardium on ventricular interaction is not known. Studies of adult hearts enclosed by the pericardium and having a relatively more compliant right than left ventricular free wall have indicated that the pericardium enhances ventricular coupling (5-18). Furthermore, other adult studies suggest that the pericardium may grow or adapt to increased volume loads imposed on the myocardium (1 7, 19-2 1). Myocardial development may actually stimulate growth and affect endogenous characteristics of the pericardium (22-24). Therefore, it is reasonable to postulate that the pericardium may affect ventricular coupling in developing hearts and that these effec...

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“…However, Janicki and Weber (19) have observed an increment of the LVPDEVP following an increase of the RV filling pressure. On the other hand, Maughan et al (24) showed that the right ventricle exerted little influence on left ventricular pressure, although ventricular interaction was investigated over a normal range of ventricular volumes without the pericardium. Furthermore, concerning the LV peak dp/dt and peak contractile element velocity in RV overload, Kelly et al (20) showed a decrease of those parameters, while relatively no change in the peak systolic pressure was found.…”

Section: Influences Of the Right Ventricular Pressure On The Le'ft Vementioning

confidence: 99%

Mechanical interaction between the ventricles

et al. 1983

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We investigated ventricular interaction by the use of six excised, perfused, canine hearts. In this preparation, we could change the filling pressure of the right and left ventricles independently, thereby breaking the normal series-pump arrangement. We found that mechanical ventricular interaction exists in diastole and in systole. Namely, not only decreased diastolic ventricular compliance, but also the reduced performance in either ventricle was found, when the opposite ventricular pressure was increased. Thus, when the opposite ventricular filling pressure increases, we suspect that systolic ventricular function of either ventricle will be depressed significantly by these two factors; i.e., the Frank-Starling effect due to decreased ventricular diastolic volume following decreased diastolic ventricular compliance, and the depressed systolic ventricular function. Clinically, these findings may be important in considering the mechanism of the occurrence of simultaneous reduced performance of both ventricles in cases when only one side of the ventricle is affected hemodynamically and its filling pressure is greatly increased in various pathological states such as heart failure.

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The effect of right ventricular filling on the pressure-volume relationship of ejecting canine left ventricle.

Cited by 57 publications

References 25 publications

Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.

Pericardial Effects on Diastolic Ventricular Interaction during Development

Mechanical interaction between the ventricles

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