The Effect of Selective Proximal Vagotomy and Pyloroplasty on Gastric Secretion and Motility in the Dog

Klempa, I; Holle, F; Brückner, W. L.; Welsch, Karl H.; Händle, Hans; Wolff, Alexander

doi:10.1001/archsurg.1971.01350120077014

Cited by 22 publications

(6 citation statements)

References 5 publications

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“…This is in contrast to results reported by Klempa et al (6) who found that the augmented secretion was particularly marked 3 -5 h after feeding. This discrep ancy can be explained by a difference in gastric emptying rate -which was significantly delayed after the operation of Klempa et al In our study the pH-electrode was used for determination of the antrum/corpus borderline and this was in all dogs found 2 -3 cm proximal to the 'anatomical border' judged by the anatomy of the nerves as used by Klempa et al (6).…”

Section: Discussioncontrasting

confidence: 99%

Parietal Cell Vagotomy in Dogs

Boné¹,

Brandsborg²,

Brandsborg³

et al. 1975

Digestion

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No change was observed in fasting Heidenhain pouch (HP) acid secretion and fasting serum gastrin concentration following parietal cell vagotomy (PCV) in six dogs whereas significant increase in food-stimulated pouch secretion and serum gastrin concentration was observed. The increase in pouch secretion after PCV took place mainly in the first 2 h after meal. The maximum serum gastrin concentration was reached at 15 min after feeding before as well as after PCV. Maximum in HP secretion was reached later, at 120 min before and at 90 min after surgery. Gastric emptying studies, using a food-barium meal, showed a slight decrease in the emptying rate after PCV in two dogs, while it was unchanged in the others. Cineradiography showed an unaffected antral motility in all dogs after PCV.

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Section: Discussioncontrasting

confidence: 99%

Parietal Cell Vagotomy in Dogs

Boné¹,

Brandsborg²,

Brandsborg³

et al. 1975

Digestion

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“…But, as tlie method used by us for measuring the gastric emptying time was not the best available for the reasons mentioned above, we believe that these result should be verified by using the gamma-camera and radiolabeled merls. Perhaps for this reason, our results are consistent only with those of Klernpa et al (30), which Fig. 4.…”

Section: Commentsupporting

confidence: 79%

“…Highly selective vagotomy (HSV) (3,27) was developed to avoid antral motor alterations and consequent delay in gastric emptying, because it preserves the vagal fibers to the antropyloric region, and, therefore, a drainage is considered unnecessary. As a matter of fact, whereas the gastric emptying of liquids was found to be enhanced after HSV (10,2 2 ,2 9 , 37), the gastric emptying of solid spheres and of a barium meal did not show significant modifications in most cases (1,2,23,25,49), with only one exception where the gastric emptying of a barium meal was found to be delayed (30). These laboratory data do not match those resulting from clinical studies showing that after HSV some patients presented symptoms of transient or persistent gastric stasis, which made drainage necessary in most instances (4,(24)(25)(26).…”

mentioning

confidence: 96%

Effect of Highly Selective Vagotomy on Gastric Motor Activity of Duodenal Ulcer Patients

Bortolotti¹,

Labò²,

Serantoni³

et al. 1978

Digestion

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The effect of highly selective vagotomy on the gastric emptying time of a food-barium meal and antral myoelectrical and manometrical activities was studied in two groups of duodenal ulcer patients: one with and another without delay in gastric emptying. Controls performed 1 and 3 months after operation showed that the group of patients with non-delayed preoperative gastric emptying kept a good emptying, only with sporadic, slight and transient disturbances of the gastric myoelectric activity. Conversely, the group of patients with delayed preoperative gastric emptying showed an increase in emptying time together with marked alterations in myoelectric and manometric activities.

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“…The procedures for vagotomy [7] and for the measurement of gastric motility [8] in dogs were similar to the reported methods. Food was withheld for 20 h with free access to water before surgery.…”

Section: Surgery For Sham-operation and Selective Gastric Complete Vamentioning

confidence: 93%

Pharmacokinetics of oral amlodipine orotate in vagotomized dogs

Kwak

Kim

Chung

et al. 2006

Biopharm. Drug Dispos.

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It was reported that gastric motility was delayed and gastric acid secretion was reduced in vagotomized dogs which mimics a low gastric acidity in humans. A delay in gastric motility causes long residence of amlodipine in the stomach. More unionized fractions of amlodipine could exist in less acidic conditions of gastrointestinal fluids, since amlodipine is a weak basic drug with pKa of 8.7. Hence, gastrointestinal absorption of amlodipine is expected to be enhanced and the time to reach a peak plasma concentration of amlodipine (Tmax) is faster in vagotomized dogs. This was proven after oral administration of an amlodipine orotate tablet at a dose of 5 mg as amlodipine in vagotomized dogs. For example, in vagotomized dogs, the total area under the plasma concentration-time curve from time zero to the last measured time, 48 h, in plasma (AUC(0-48 h)) was significantly greater (725 versus 348 ng h/ml) and Tmax was significantly shorter (1.50 versus 5.00 h) than those in dogs without vagotomy.

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The Effect of Selective Proximal Vagotomy and Pyloroplasty on Gastric Secretion and Motility in the Dog

Cited by 22 publications

References 5 publications

Parietal Cell Vagotomy in Dogs

Parietal Cell Vagotomy in Dogs

Effect of Highly Selective Vagotomy on Gastric Motor Activity of Duodenal Ulcer Patients

Pharmacokinetics of oral amlodipine orotate in vagotomized dogs

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