The effect of selenium supplementation on outcome in very low birth weight infants: A randomized controlled trial

Antioxidants as Therapy in the Newborn: Some Words of Caution

“…The limitations described above may explain some of the disappointing results from trials of antioxidants for the prevention of neonatal disease, including vitamin E (77-79), allopurinol (80), and selenium supplementation (81). The outcomes of other antioxidant interventions in ongoing trials, such as intratracheal recombinant human SOD (82), are yet to be determined.…”

Selenium and Vitamin A and E in the Nutrition of Very Low-Birth Weight Preterm Infants

“…The authors observed that glutathione peroxidase and plasma selenium concentrations were lower in the non-supplemented group at both time points. That study was performed in New Zealand, a country that has very low soil selenium levels [11].…”

“…A decrease in blood selenium concentrations is observed in VLBW infants receiving parenteral nutrition without selenium or non-supplemented formulas [11]. Therefore, these formulas are not recommended for preterm infants.…”

Nutritional support and bronchopulmonary dysplasia

“…Although there was no link between Se levels during the study and outcome, lower pre-randomization Se levels were associated with worse outcomes. 14 …”