The effect of simvastatin on bone formation and ceramic resorption in a peri-implant defect model

In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects

“…Cortical microarchitecture bone parameters of the critical-size bone defect analysed by micro-CT. Trabecular bone parameters in the volume of interest analysed by micro-CT.observed[8,[28][29][30][31][33][34][35][36]. However, the immediate release of RSV from ACS found in the present investigation might have reduced the effect of RSV on bone formation.…”

“…An interesting alternative would be administering statins locally to bone sites either directly [28] or by using a suitable slow release delivery system. Some of the delivery systems that have been used with statins include calcium sulphate [29], propylene glycol alginate [30], methylcellulose gel [31,32], b-tricalcium phosphate [33] and collagen sponges [34][35][36]. All the reported delivery systems were combined either with simvastatin or fluvastatin and showed positive effects on bone formation.…”

Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

“…Despite the evident reduction in inflammation in the DBBMSIM-2 group, the two doses used delayed bone repair. In a study conducted by Ma et al, 20 local delivery of 0.1, 0.9, or 1.7 mg of simvastatin to tibia implants in combination with beta-tricalcium phosphate also had a negative effect on bone repair. Further studies aiming at determining optimal doses and routes of administration of statins are required in order to evaluate more accurately the use of these drugs for bone repair.…”

“…5,9,10 Others, however, have found no beneficial effects. 9,19,20 The ideal doses and carriers have yet to be determined, and the issue remains controversial. Low doses have no impact on bone repair, whereas high doses can stimulate inflammation.…”

Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts

“…Several investigators reported simvastatin-induced osteoblastic differentiation through its bone morphogenic protein-2 promoting effect, which resulted in greater new bone formation and improved fracture healing (53)(54)(55)(56)(57). Simvastatin has been used in the treatment of periodontal and peri-implant bone defects as well in socket preservation (58)(59)(60). One interesting fact about simvastatin metabolism is that the parent drug is without intrinsic activity.…”